Structure-Function Relationships of 1,4-Dihydropyridines: Ligand and Receptor Perspectives
Are there specific 1,4-dihydropyridine sites?
How many classes of such sites exist?
What are the structural demands at these sites?
- 4.How may activator and antagonist ligands be differentiated?
What is the relationship of binding sites to the Ca2+ channel and channel permeation processes?
What relationship does this site(s) have to the actions of other structural categories of Ca2+ channel ligands?
What is the basis for any tissue selectivity of the 1,4-dihydropyridines?
Are there endogenous ligands for the Ca2+ channel?
KeywordsCalcium Channel Antagonist Tonic Component Radioligand Binding Study Calcium Antag Dihydropyridine Calcium Channel Antagonist
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