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Ca Entry into Vascular Smooth Muscle

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Cardiovascular Effects of Dihydropyridine-Type Calcium Antagonists and Agonists

Part of the book series: Bayer-Symposium ((BAYER-SYMP,volume 9))

Abstract

This paper is intended as a brief review of our work on the mechanisms whereby Ca enters into the myoplasm of vascular smooth muscle cells. We propose that there are two components to this Ca entry process. The first is the permeation of Ca ions through the proteolipid plasmalemma mediated by a resting Ca leak and several excitable channels. The second component is the diffusion through a narrow space near the inner surface of the membrane which contains a regulated Ca2+ buffer. The evidence for the resting Ca2+ leak and the excitable Ca2+ channels as well as that for the regulated buffer was derived from correlations between 45Ca influxes and force development in the rabbit aorta.

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Authors
  1. C. Van Breemen
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  2. K. Hwang
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  3. R. Loutzenhiser
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  4. S. Lukeman
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  5. H. Yamamoto
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Editor information

Editors and Affiliations

  1. Physiologisches Institut, Universität Freiburg, Hermann-Herder-Straße 7, D-7800, Freiburg i. Br., Germany

    Albrecht Fleckenstein

  2. Department of Pharmacology, University of Miami School of Medicine, P.O. Box 016189, Miami, FL, 33101, USA

    Cornelius Van Breemen D.V.M., Ph.D.

  3. Abteilung Herz-Kreislauf-Pharmakologie II, Bayer AG, Institut für Pharmakologie, Postfach 10 1709, D-5600, Wuppertal 1, Germany

    Rainer Gross

  4. Bayer AG, Institut für Pharmakologie, Postfach 10 1709, D-5600, Wuppertal 1, Germany

    Friedrich Hoffmeister

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© 1985 Springer-Verlag Berlin Heidelberg

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Van Breemen, C., Hwang, K., Loutzenhiser, R., Lukeman, S., Yamamoto, H. (1985). Ca Entry into Vascular Smooth Muscle. In: Fleckenstein, A., Van Breemen, C., Gross, R., Hoffmeister, F. (eds) Cardiovascular Effects of Dihydropyridine-Type Calcium Antagonists and Agonists. Bayer-Symposium, vol 9. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70499-4_4

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  • DOI: https://doi.org/10.1007/978-3-642-70499-4_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70501-4

  • Online ISBN: 978-3-642-70499-4

  • eBook Packages: Springer Book Archive

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