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Mechanism of Calcium Channel Modulation by Dihydropyridine Agonists and Antagonists

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Cardiovascular Effects of Dihydropyridine-Type Calcium Antagonists and Agonists

Part of the book series: Bayer-Symposium ((BAYER-SYMP,volume 9))

Abstract

Single cardiac Ca channels exhibit three modes of gating, expressed as current records with brief openings occurring in bursts (mode 1), records with long-lasting openings and very brief closings that appear only rarely (mode 2), and records that lack openings because of channel unavailability (mode 0). The dihydropyridine Ca agonist Bay K 8644 enhances Ca channel current by promoting mode 2, while the Ca antagonists nitrendipine and nimodipine reduce the current by favoring mode 0.

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Authors
  1. P. Hess
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  2. J. B. Lansman
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  3. R. W. Tsien
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Editor information

Editors and Affiliations

  1. Physiologisches Institut, Universität Freiburg, Hermann-Herder-Straße 7, D-7800, Freiburg i. Br., Germany

    Albrecht Fleckenstein

  2. Department of Pharmacology, University of Miami School of Medicine, P.O. Box 016189, Miami, FL, 33101, USA

    Cornelius Van Breemen D.V.M., Ph.D.

  3. Abteilung Herz-Kreislauf-Pharmakologie II, Bayer AG, Institut für Pharmakologie, Postfach 10 1709, D-5600, Wuppertal 1, Germany

    Rainer Gross

  4. Bayer AG, Institut für Pharmakologie, Postfach 10 1709, D-5600, Wuppertal 1, Germany

    Friedrich Hoffmeister

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© 1985 Springer-Verlag Berlin Heidelberg

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Hess, P., Lansman, J.B., Tsien, R.W. (1985). Mechanism of Calcium Channel Modulation by Dihydropyridine Agonists and Antagonists. In: Fleckenstein, A., Van Breemen, C., Gross, R., Hoffmeister, F. (eds) Cardiovascular Effects of Dihydropyridine-Type Calcium Antagonists and Agonists. Bayer-Symposium, vol 9. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70499-4_3

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  • DOI: https://doi.org/10.1007/978-3-642-70499-4_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70501-4

  • Online ISBN: 978-3-642-70499-4

  • eBook Packages: Springer Book Archive

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