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The Use of Calcium Antagonists in the Treatment of Arterial Hypertension

  • G. Leonetti
  • L. Sampieri
  • C. Cuspidi
  • M. Fruscio
  • R. Gradnik
  • L. Terzoli
  • L. Rupoli
  • A. Zanchetti
Conference paper
Part of the Bayer-Symposium book series (BAYER-SYMP, volume 9)

Abstract

It is well known that an increase of total peripheral resistances is responsible of the blood pressure elevation in the majority of hypertensive patients [1–3]; for this reason vasodilating drugs should theoretically be preferred to other antihypertensive drugs with different mechanisms of action. Despite this pathophysiological consideration, the use of the vasodilating drugs has been very limited in antihypertensive treatment in the past due to the occurrence of two side effects interfering with their efficacy and reducing the patient’s compliance. These side effects are sodium and water retention and reflex activation of the sympathetic nervous system [4, 5].

Keywords

Calcium Antagonist Sympathetic Nervous System Blood Pressure Reduction Total Peripheral Resistance Sodium Retention 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Lund-Johansen P (1980) Hemodynamics in essential hypertension. State of art: review. Clin Sci 59:343s.Google Scholar
  2. 2.
    Frolich ED, Tarazi RC, Dustan HP (1969) Re-examination of the hemodynamics of hypertension. Am J Med Sci 257:9.CrossRefGoogle Scholar
  3. 3.
    Conway J (1984) Hemodynamic aspects of essential hypertension in humans. Physiol Rev 64:617.PubMedGoogle Scholar
  4. 4.
    Koch-Weser J (1979) Vasodilator drugs in treatment of hypertension. Arch Int Med 113:1017.Google Scholar
  5. 5.
    Leonettii G, Bonazzi O, Grazi S, Ligresti A, Romano S, Zanchetti A (1971) Cardiovascular and renal effects of acute administration of a new antihypertensive compound: guancydine. Eur J Pharmacol 4:1.CrossRefGoogle Scholar
  6. 6.
    Gross F (1977) Drugs acting on arteriolar smooth muscle (vasodilator drugs). In: F. Gross (ed) Antihypertensive agents. Springer Berlin Heidelberg New York, pp 397–476.Google Scholar
  7. 7.
    Leonetti G, Cuspidi C, Sampieri L, Terzoli L, Zanchetti A (1982) Comparison of cardiovascular, renal and humoral effects of acute administration of two calcium channel blockers in normotensive and hypertensive subjects. J Cardiovasc Pharmacol 4:319.CrossRefGoogle Scholar
  8. 8.
    Brown B, Churchill P (1983) Renal effects of methoxy-verapamil in anesthetized rats. J Pharmacol Exp Ther 225:372.PubMedGoogle Scholar
  9. 9.
    Dietz IR, Davis JO, Freeman RH, Villareal D, Echtenkamp SF (1983) Effects of intrarenal infusion of calcium entry blockers in anesthetized dogs. Hypertension 5:482.PubMedGoogle Scholar
  10. 10.
    Marre M, Misumi R, Raemsch KD, Corvol P, Menard J (1982) Diuretic and natriuretic effects of nifedipine in isolated perfused rat kidneys. J Pharmacol Exp Ther 223:263.PubMedGoogle Scholar
  11. 11.
    Di Bona GF, Sawin LL (1984) Renal tubular site of action of felodipine. J Pharmacol Exp Ther 228:420.Google Scholar
  12. 12.
    Doyle AE, Anavekar SN, Oliver LE (1980) A clinical trial of verapamil in the treatment of hypertension. In: A. Zanchetti, D. M. Krikler (eds) Calcium antagonism in cardiovascular therapy: experience with verapamil. Excerpta Medica, Amsterdam pp 252–259.Google Scholar
  13. 13.
    Lederballe-Pederson O (1983) The experimental use of calcium antagonists in the treatment of arterial hypertension. Postgrad Med J 59(Suppl 2): 84.Google Scholar
  14. 14.
    Leonetti G, Sala C, Bianchini C, Terzoli L, Zanchetti A (1980) Antihypertensive and renal effects of orally administered verapamil. Eur J Clin Pharmacol 18:375.PubMedCrossRefGoogle Scholar
  15. 15.
    Olivari MT, Bartorelli C, Polese A, Fiorentini C, Guazzi M (1979) Treatment of hypertension with nifedipine, a calcium antagonist agent. Circulation 59:1056.PubMedGoogle Scholar
  16. 16.
    Leonetti G, Pasotti C, Ferrari GP, Zanchetti A (1980) Double blind comparison of the antihypertensive effects of verapamil and propranolol. In: Zanchetti A, Krikler DM (eds) Calcium antagonism in cardiovascular therapy: experience with verapamil. Excerpta Medica, Amsterdam pp 260–269.Google Scholar
  17. 17.
    Leonetti G, Pasotti C, Ferrari GP, Zanchetti A (1984) Verapamil and propranolol: a comparison of two antihypertensive agents. Acta Med Scand Suppl 681:137.PubMedGoogle Scholar
  18. 18.
    Corea L, Bentivoglio M, Verdecchia P, Providenza M (1984) Calcium antagonists and diuretics in arterial hypertension: a useful combination. J Roy Soc Med 62:23.Google Scholar
  19. 19.
    Wicher P, Roudaut R, Gosse P, Dall’Occhio M (1984) Short and long-term treatment of mild to moderate hypertension with verapamil. J Roy Soc Med 62:45.Google Scholar
  20. 20.
    MacInnes GF, Findlay I, Murray GD, Dargie HJ (1984) Calcium antagonists and betablockers. J Roy Soc Med 62:69.Google Scholar
  21. 21.
    Muller FB, Bolli P, Erne P, Block LH, Kiowski W, Bühler FR (1984) Antihypertensive therapy with long-acting calcium antagonist nitrendipine. J Cardiovasc Pharmacol 6 (Suppl 7): 1073s.Google Scholar
  22. 22.
    Rüddel H, Schmieder R, Lagenwitz W, Neus J, Wagner O, Wilhelm von Eiff A (1984) Efficacy of nitrendipine as baseline antihypertensive therapy. J Cardiovasc Pharmacol 6 (Suppl 7): 1049s.Google Scholar
  23. 23.
    MacGregor G, Rotellar C, Markandu ND, Smith SJ, Sagnella GA (1982) Contrasting effects of nifedipine, captopril and proranolol in normotensive and hypertensive subjects. J Cardiovasc Pharmacol 4 (Suppl 2):358s.Google Scholar
  24. 24.
    Weber MA, Drayer JIM (1984) The calcium channel blocker nitrendipine in single and mulitple-agent antihypertensive regimens: preliminary report of a multicenter study. J Cardiovasc Pharmacol 6 (Suppl 7): 1077s.Google Scholar
  25. 25.
    Nannan ME, Melin JA, Vanbutsele RJ, Lavenne F, Detry JMR (1984) Acute and long-term effects of nitrendipine on resting and exercise hemodynamics in essential hypertension. J Cardiovasc Pharmacol 6 (Suppl 7): 1043s.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • G. Leonetti
  • L. Sampieri
  • C. Cuspidi
  • M. Fruscio
  • R. Gradnik
  • L. Terzoli
  • L. Rupoli
  • A. Zanchetti

There are no affiliations available

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