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Voltage-Dependent Modulation of Cardiac Ca-Channels by Dihydropyridines

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Cardiovascular Effects of Dihydropyridine-Type Calcium Antagonists and Agonists

Part of the book series: Bayer-Symposium ((BAYER-SYMP,volume 9))

Abstract

The purpose of this chapter is to discuss recent observations made in this and other laboratories that demonstrate voltage-dependent modulation of Ca-channel currents in cardiac cells by dihydropyridine Ca-channel antagonists and agonists. In order to interpret these observations, the effect of membrane potential on the state of the Ca-channel is first discussed. Then, after reviewing the experimental data that show voltage-dependent changes in drug potency, the results are discussed within the framework of the modulated receptor hypothesis of Hille (1977) and Hondeghem and Katzung (1977) that relates drug-receptor interactions to changes in state of a channel.

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Authors
  1. R. S. Kass
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  2. M. C. Sanguinetti
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  3. P. B. Bennett
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  4. B. E. Coplin
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  5. D. S. Krafte
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Editor information

Editors and Affiliations

  1. Physiologisches Institut, Universität Freiburg, Hermann-Herder-Straße 7, D-7800, Freiburg i. Br., Germany

    Albrecht Fleckenstein

  2. Department of Pharmacology, University of Miami School of Medicine, P.O. Box 016189, Miami, FL, 33101, USA

    Cornelius Van Breemen D.V.M., Ph.D.

  3. Abteilung Herz-Kreislauf-Pharmakologie II, Bayer AG, Institut für Pharmakologie, Postfach 10 1709, D-5600, Wuppertal 1, Germany

    Rainer Gross

  4. Bayer AG, Institut für Pharmakologie, Postfach 10 1709, D-5600, Wuppertal 1, Germany

    Friedrich Hoffmeister

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© 1985 Springer-Verlag Berlin Heidelberg

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Kass, R.S., Sanguinetti, M.C., Bennett, P.B., Coplin, B.E., Krafte, D.S. (1985). Voltage-Dependent Modulation of Cardiac Ca-Channels by Dihydropyridines. In: Fleckenstein, A., Van Breemen, C., Gross, R., Hoffmeister, F. (eds) Cardiovascular Effects of Dihydropyridine-Type Calcium Antagonists and Agonists. Bayer-Symposium, vol 9. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70499-4_12

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  • DOI: https://doi.org/10.1007/978-3-642-70499-4_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70501-4

  • Online ISBN: 978-3-642-70499-4

  • eBook Packages: Springer Book Archive

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