Abstract
We have investigated the cellular mechanism(s) of the inotropic effects in mammalian heart muscle of the 1,4-dihydropyridine compounds, nitrendipine and Bay k 8644. Our primary tool in this work has been the Ca2+-sensitive photoprotein, aequorin (see Blinks et al. 1982), which we have used to observe the changes in cytoplasmic free [Ca2+) that accompany the twitch contraction of mammalian ventricular muscle.
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© 1985 Springer-Verlag Berlin Heidelberg
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Wier, W.G., Yue, D.T. (1985). The Effects of 1,4-Dihydropyridine Type Ca2+-Channel Antagonists and Agonists on Intracellular [Ca2+) Transients Accompanying Twitch Contraction of Heart Muscle. In: Fleckenstein, A., Van Breemen, C., Gross, R., Hoffmeister, F. (eds) Cardiovascular Effects of Dihydropyridine-Type Calcium Antagonists and Agonists. Bayer-Symposium, vol 9. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70499-4_11
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DOI: https://doi.org/10.1007/978-3-642-70499-4_11
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