Mechanisms and Treatment of Cytotoxic-Induced Nausea and Vomiting

  • A. L. Harris
  • B. M. J. Cantwell
Part of the Advances in Applied Neurological Sciences book series (NEUROLOGICAL, volume 3)

Abstract

The most important subjective side-effects of cancer chemotherapy are nausea and vomiting. It is not known how such a wide variety of cytotoxic agents with different structures, modes of action and lipid solubility produce nausea and vomiting. The ability to recognise poisonous substances may have been of great evolutionary value but is a disadvantage in managing patients with cancer.

Keywords

Placebo Dopamine Cyclophosphamide Benzimidazole Teratoma 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • A. L. Harris
    • 1
  • B. M. J. Cantwell
    • 2
  1. 1.Department of RadiotherapyUniversity of Newcastle-upon-Tyne,Newcastle General HospitalNewcastle-upon-TyneUK
  2. 2.Wolfson Unit of Clinical PharmacologyUniversity of Newcastle-upon-TyneUK

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