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Anatomy and Physiology of the Chemoreceptor Trigger Zone and Area Postrema

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Nausea and Vomiting: Mechanisms and Treatment

Part of the book series: Advances in Applied Neurological Sciences ((NEUROLOGICAL,volume 3))

Abstract

It was not until the vomiting centre itself was correctly localized in the bulbar reticular formation that the idea of a separate chemosensory station could be formulated (Borison and Wang 1953). Figure 1 shows where the vomiting centre was thought to be located before 1949 (panel A) and then where it was mapped by Borison and Wang (1949) (panel B). Earlier workers (Hatcher and Weiss 1923) simply assumed that the vomiting centre was inherently responsive to “centrally-acting” emetic drugs applied locally to the ala cinerea on the brain surface; whereas, we used direct electrical stimulation to activate the centre in the parenchymal reticular formation. Indeed, there is at present no neuropharmacological basis for attributing any functional chemoselectivity to the particular medullary neurons that comprise the vomiting centre.

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Author information

Authors and Affiliations

  1. Department of Pharmacology and Toxicology, Institute of Brain Stem Studies, Dartmouth Medical School, Hanover, New Hampshire, 03755, USA

    H. L. Borison

Authors
  1. H. L. Borison
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Editor information

Editors and Affiliations

  1. Royal Navy, Corpus Christi College, Oxford, UK

    Christopher J. Davis BSc (Hons), MB, BS, AKC (Surgeon Lieutenant Commander, Senior Specialist in Applied Physiology (Royal Navy) and Research Training Fellow) (Surgeon Lieutenant Commander, Senior Specialist in Applied Physiology (Royal Navy) and Research Training Fellow)

  2. University Department of Clinical Pharmacology, Radcliffe Infirmary, OX2 6HE, Oxford, UK

    Christopher J. Davis BSc (Hons), MB, BS, AKC (Surgeon Lieutenant Commander, Senior Specialist in Applied Physiology (Royal Navy) and Research Training Fellow) (Surgeon Lieutenant Commander, Senior Specialist in Applied Physiology (Royal Navy) and Research Training Fellow)

  3. Medical Department, Janssen Pharmaceutical Ltd (UK), OX12 ODQ, Wantage Oxfordshire, UK

    Gerry V. Lake-Bakaar BSc (Hons), MD, MRCP (Research Gastroenterology Physician and Director of Medical Affairs) (Research Gastroenterology Physician and Director of Medical Affairs)

  4. University of Oxford, Oxford, UK

    David G. Grahame-Smith MA, MB, BSc, PhD, FRCP (Rhodes Professor of Clinical Pharmacology, Fellow of Corpus Christi College, Honorary Director of the MRC Clinical Pharmacology Unit, Radcliffe Infirmary, Oxford and Honorary Consultant, Physician) (Rhodes Professor of Clinical Pharmacology, Fellow of Corpus Christi College, Honorary Director of the MRC Clinical Pharmacology Unit, Radcliffe Infirmary, Oxford and Honorary Consultant, Physician)

  5. General Internal Medicine and Clinical Pharmacology, Oxford Health Authority, OX2 6HE, Oxford, UK

    David G. Grahame-Smith MA, MB, BSc, PhD, FRCP (Rhodes Professor of Clinical Pharmacology, Fellow of Corpus Christi College, Honorary Director of the MRC Clinical Pharmacology Unit, Radcliffe Infirmary, Oxford and Honorary Consultant, Physician) (Rhodes Professor of Clinical Pharmacology, Fellow of Corpus Christi College, Honorary Director of the MRC Clinical Pharmacology Unit, Radcliffe Infirmary, Oxford and Honorary Consultant, Physician)

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© 1986 Springer-Verlag Berlin Heidelberg

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Borison, H.L. (1986). Anatomy and Physiology of the Chemoreceptor Trigger Zone and Area Postrema. In: Davis, C.J., Lake-Bakaar, G.V., Grahame-Smith, D.G. (eds) Nausea and Vomiting: Mechanisms and Treatment. Advances in Applied Neurological Sciences, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70479-6_2

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  • DOI: https://doi.org/10.1007/978-3-642-70479-6_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70481-9

  • Online ISBN: 978-3-642-70479-6

  • eBook Packages: Springer Book Archive

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