Zusammenfassung
Die Rachitis, definiert als Systemkrankheit des kindlichen Skeletts, die pathologischanatomisch durch eine ungenügende Kalkeinlagerung in osteoides Gewebe gekennzeichnet ist, wurde bereits vor rund 400 Jahren eingehend beschrieben (Reusner 1582). Die rachitisheilende Wirkung von ultraviolettem Licht wurde 1919 durch Huldschinsky nachgewiesen. 1925 und 1926 entdeckte Windaus das Vitamin D und erhielt dafür 1928 den Nobelpreis für Chemie. Von dieser Zeit an konnte eine medikamentöse Rachitisprophylaxe betrieben werden, zunächst als Stoßprophylaxe, die dann seit Anfang der 70er Jahre zunehmend durch die physiologische kontinuierliche Rachitisprophylaxe ersetzt wurde. Im gleichen Ausmaß, wie die auf einen Vitamin-D-Mangel beruhenden Rachitiden aufgrund dieser Prophylaxe an Bedeutung verloren, traten die Vitamin-D-resistenten Formen in den Vordergrund.
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Kruse, K. (1986). Hereditäre Störungen des Vitamin-D-Stoffwechsels. In: Frick, P., von Harnack, GA., Kochsiek, K., Martini, G.A., Prader, A. (eds) Ergebnisse der Inneren Medizin und Kinderheilkunde / Advances in Internal Medicine and Pediatrics. Ergebnisse der Inneren Medizin und Kinderheilkunde / Advances in Internal Medicine and Pediatrics, vol 54. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70473-4_3
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