Advertisement

Radioonkologische Innovationen zur Therapie des Bronchialkarzinoms

  • W. Alberti
Conference paper
  • 9 Downloads

Zusammenfassung

Die Strahlentherapie stellt eine kurative Behandlung nur für einen kleinen Anteil der Bronehialkarzinomträger mit limitierter Erkrankung dar. Die 5-Jahres-Überlebensrate beträgt ungefähr 5%, wobei die Todesursache bei der Mehrzahl der Patienten die ausgedehnte lymphatische und hämatogene Metastasierung darstellt.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Abadir R, Muggia FM (1975) Irradiated lung cancer: an autopsy analysis of spread pattern. Radiology 114: 427–430PubMedGoogle Scholar
  2. Alberti W, Niederle N, Bamberg M, Konietzko N, Scherer E (1984) Radiotherapy of inoperable non-small cell lung cancer - twice a week tratment. 3. ESTRO-Meeting; JerusalemGoogle Scholar
  3. Bergsagel, DE, Jenkin RDT, Pringle JF, White DM, Fetterly JCM, Klaassen DJ, McDermot RSR (1972) Lung cancer: clinical trial of radiotherapy plus cyclophosphamide. Cancer 30: 621–627PubMedCrossRefGoogle Scholar
  4. Bleehen NM (1979) Role of radiation therapy and other modalities in the treatment of small cell carcinoma of the lung. In: Muggia F, Rozenczweig M (eds) Lung cancer: Progress in therapeutic research. Raven Press, New YorkGoogle Scholar
  5. Bush RS, Jenkin RDT, Allt WEC, Beale FA, Bean H, Dembo AJ, Pringle JF (1978) Definitive evidence for hypoxic cells influencing cure in cancer therapy. Brit J Cancer [Suppl III] 37: 302–306Google Scholar
  6. Cade IS, McEwen JB (1978) Clinical trials of radiotherapy in hyperbaric oxygen at Portsmouth. Clin Radiol 29: 333–338PubMedCrossRefGoogle Scholar
  7. Cox JD, Kesner R, Mietlowski W, Petrovich Z (1979) Influence of cell type on failure pattern after irradiation for locally advanced carcinoma of the lung. Cancer 44: 94–98PubMedCrossRefGoogle Scholar
  8. Eagan RT, Lee RE, Frytak S, Fleming TR, Cregan ET, Ingle JN, Kools LK (1979) Randomized trial of thoracic irradiation plus combination chemotherapy for unresectable adenocarcinoma and large cell carcinoma of the lung. Int J Radiat Oncol Biol Phys 5: 1401–1405PubMedGoogle Scholar
  9. Eichhorn HJ, Lessel A (1976) A comparison between combined neutron- and telecobalt-therapy with telecobalt-therapy alone for cancer of the bronchus. Br J Radiol 49: 880–882PubMedCrossRefGoogle Scholar
  10. Ellis F (1974) Letter: The NSD concept and radioresistant tumors. Br J Radiol 47: 909PubMedCrossRefGoogle Scholar
  11. Ellis F, Goldson AL (1977) Once a week treatments. Int J Radiol Oncol Biol Phys 2: 537–548CrossRefGoogle Scholar
  12. Fitzpatrick DJ, Rider WD, (1976) Half-body radiotherapy. Int J Radiol Biol Phys 1: 197–207CrossRefGoogle Scholar
  13. Fowler JF, Adams GE, Denekamp J (1976) Radiosensitizer of hypoxic cells in solid tumors. Cancer Treat Rev 3: 227–256PubMedCrossRefGoogle Scholar
  14. Ghilezan N, Milea N, Tamburlini S (1976) Telecobalt therapy for malignant lung tumors. Acta Radiol Ther 15: 394–400Google Scholar
  15. Glassburn JR, Brady LN, Plenk HP (1977) Hyperbaric oxygen in radiation therapy. Cancer 39: 751–765PubMedCrossRefGoogle Scholar
  16. Hand JW, Ter Haar G (1981) Heating techniques in hyperthermia. I. Introduction and assessment of techniques (review article). Br J Radiol 54: 443–446Google Scholar
  17. Herskovic A, Lee S, Scheer A, Ornitz R (1979) Fast neutron experience: Epidermoid carcinoma of the upper aerodigestive tract. Proc Am Soc Ther Rad (ASTR) Int J Radiat Oncol Biol Phys 5: 53Google Scholar
  18. Higi M, Schreiber D, Arndt D, Henning A, Schmitt G (1982) Cisplatin als radiosensibilisierende Substanz bei der Behandlung solider Tumoren. Strahlentherapie 158: 616–619PubMedGoogle Scholar
  19. Holsti LR (1984) Combination chemotherapy and split-course radiotherapy versus radiotherapy alone in non-small cell lung-cancer. Finnish Lung Cancer Group. Am Ass Cancer Res 25: 213Google Scholar
  20. Houtte P van, Klastersky J, Nguyen H, Michel J, Vandermoten G, Rocmans P, Dumont JP, Devriendt P, Sculier JP, Longeval E, Flemale A, Mommen P (1984): Comparative randomized study of chest radiotherapy precedea or not by chemotherapy with cisplatin, etoposide and vindesine for the treatment of non-small cell lung cancer. Am Ass Cancer Res 25: 198Google Scholar
  21. Komaki R, Cox J, Eisert DR (1977) Irradiation of bronchial carcinoma. II. Pattern of spread an potential for prophylactic radiation. Int J Radiat Oncoly Biol Phys 2: 441–446CrossRefGoogle Scholar
  22. Le Veen HH, Wapnich S, Piccone V, Falk G, Ahmed N (1976) Tumor eradication by radiofrequency therapy. Response in 21 patients. J Amer Med Assoc 235: 2198–2200CrossRefGoogle Scholar
  23. McEwen JB (1971) Methods of improving results of radiation. IV. Hyperbaric oxygen. In: Deeley TJ (ed) Modern radiotherapy carcinoma of the bronchus. Butterworth, London, pp 241–245Google Scholar
  24. Muggia FM, Glatstein E (1979) Summary of investigations on platinum compounds and radiation interactions. Int J Radiat Oncol Biol Phys 5: 1407PubMedGoogle Scholar
  25. Overgaard J, Khan AR (1981) Selective enhancement of radiation response in a C3H mammary carcinoma by cisplatin. Cancer Treat Rep 65: 501–503PubMedGoogle Scholar
  26. Patt HM (1953) protective mechanisms in ionizing radiation injury. Physiol Rev 33:35–96PubMedGoogle Scholar
  27. Rissanen PM, Tikka V, Holsti LR (1968) Autopsy findings in lung cancer treated with megavoltage radiotherapy. Acta Radiol 7: 433–442CrossRefGoogle Scholar
  28. Rubin P, Perez CA, Keller B (1976) The logical basis of radiation treatment policies in the multidisciplinary approach of the lung cancer. In: Israel L, Chahinian P (eds) Lung cancer: Facts, problems and prospects. Academic Press, New YorkGoogle Scholar
  29. Rubin P, Cowen RB, Rubin DJ (eds) (1979) The radiation oncology research program. Recommended research proposals. Int J Radiat Oncol Biol Phys 5: 677–698Google Scholar
  30. Salazar OM, Zagdars G (1981) Radiation therapy - new approaches. In: Livingston RB (ed) Lung cancer 1. Marinus Nijhoff, Den Haag Boston London, pp 113–156Google Scholar
  31. Salazar OM, Rubin P, Brown JC, Feldstein ML, Keller BE (1976) The assessment of tumor response to irradiation of lung cancer: Continuous versus split-course regiments. Int J Radiat Oncol Biol Phys 1: 1107–1118PubMedCrossRefGoogle Scholar
  32. Salazar OM, Rubin P, Keller BE, Scarantino CW (1978) Systemic (half-body) radiation therapy: Response and toxicity. Int J Radiat Oncol Biol Phys 4: 937–950PubMedGoogle Scholar
  33. Salazar OM, Creech RH, Rubin P, Bennett JM, Mason BA, Young JJ, Scarantino CW, Catalano RB (1980) Half-body and local chest irradiation as consolidation following response to standard induction chemotherapy for disseminated small cell lung cancer. An Eastern Cooperative Oncology Group Pilot Report. Proc Am Soc Ther Radiol Int J Rad Oncol Biol Phys 5:60, 1979; Int J Radiat Oncol Biol Phys 6: 1093–1102CrossRefGoogle Scholar
  34. Schumacher W (1976) The use of high energy electrons in the treatment of inoperable lung and bronchogenic carcinoma. In: Kramer S (ed) High photons and electrons. John Wiley and Sons, New York, pp 257–284Google Scholar
  35. Sealy R (1979) Combined radiotherapy and chemotherapy in non-small cell carcinoma of the lung. Prog Cancer Res Ther 11: 315–323Google Scholar
  36. Sugaar S, Le Veen HH (1979) A histopathological study on the effects of radiofrequency thermotherapy on malignant tumors of the lung. Cancer 43: 767–783PubMedCrossRefGoogle Scholar
  37. Suit HD, Gerweck LE (1979) Potential for hypertermia and radiation therapy. Cancer Res 39: 2290–2298PubMedGoogle Scholar
  38. Utley JF, Phillips TL, Kane LF, Wharman MD, Wara WM (1974) Differential radioprotection of euoxic and hypoxic mouse mammary tumors by a thiophosphate compound. Radiology 110: 213–216PubMedGoogle Scholar
  39. White JE, Boles M (1981) The role of radiation therapy in the treatment of regional non-small (oat)-cell carcinoma of the lung. In: Livingston RB (ed) Lung cancer 1, Martinus Nijhoff, Den Haag Boston London, pp 113–156Google Scholar
  40. Wils JA, Utama I, Naus A, Verschueren TA (1984) Phase II randomized trial of radiotherapy alone versus the sequential use of chemotherapy and radiotherapy in stage III non-small cell lung cancer. Phase II trial of chemotherapy alone in stage IV non-small cell lung cancer. Eur J Cancer Clin Oncol 20: 911–914PubMedCrossRefGoogle Scholar
  41. Yuhas JM, Storer JB (1969) Differential chemoprotection of normal and malignant tissues. J Natl Cancer Inst 42: 331–335PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • W. Alberti

There are no affiliations available

Personalised recommendations