Skip to main content
SpringerLink
Log in

Incidence and Prognostic Significance of DNA Aneuploidy in Childhood Acute Lymphoblastic Leukemia

  • Conference paper
Tumor Aneuploidy

Abstract

Recent improvements in cytogenetic technology provided the means to identify chromosomal abnormalities in the majority of children with acute lymphoblastic leukemia (ALL) [1–8]. In addition to numeric aberrations, detected in 23% to 39% of all cases with evaluable metaphases [1–4], specific nonrandom translocations have been described [5–8]. Cytogenetic studies have also emphasized the clinical significance of chromosomal aberrations in relation to previously identified risk factors such as male sex, high white blood cell count (WBC), age and T-cell phenotype [2, 3]. The applicability of cytogenetic techniques, however, is limited by the laborious and time consuming processing of samples and requires cell proliferation in vitro for the evaluation of metaphases.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Rowley JD (1978) The cytogenetics of acute leukemia. Clinics Haemat 7,2:385

    Article  CAS  Google Scholar 

  2. Arthur DC, Bloomfield CD, Lindquist LL, Peterson BA, Nesbit ME (1981) Chromosome abnormalities in acute lymphoblastic leukemia (ALL): Frequency and clinical implications. Proc ASCO 22:345 (Abstr)

    Google Scholar 

  3. Bloomfield CD (1981) Clinical significance of chromosomal abnormalities in acute lymphoblastic leukemia (ALL). A preliminary report of the Third International Workshop on Chromosomes in Leukemia (TIWCL). Proc ASCO 22:228 (Abstr)

    Google Scholar 

  4. Kaneko Y, Rowley JD, Variakojis D, Chilcote RR, Check I, Sakurai M (1982) Correlation of karyotype with clinical features in acute lymphoblastic leukemia. Cancer Res 42,7:2918

    CAS  PubMed  Google Scholar 

  5. Priest JR, Robison LL, McKenna RW, Lindquist LL, Warkentin PI, LeBien TW, Woods WG, Kersey JH, Coccia PF, Nesbit ME (1980) Philadelphia chromosome positive childhood acute lymphoblastic leukemia. Blood 56:12

    Google Scholar 

  6. Cimino MC, Rowley JD, Kinnealy A, Variakojis D, Golomb HM (1979) Banding studies of chromosomal abnormalities in patients with acute lymphoblastic leukemia. Cancer Res 39:227

    CAS  PubMed  Google Scholar 

  7. Oshimura M, Freeman AI, Sandberg AA (1977) Chromosomes and causation of human cancer and leukemia. XXVI: Banding studies in acute lymphoblastic leukemia (ALL). Cancer 40:1161

    Article  CAS  PubMed  Google Scholar 

  8. Whang-Peng J, Knutsen T, Ziegler J, Leventhal B (1976) Cytogenetic studies in acute lymphoblastic leukemia: Special emphasis on long-term survival. Med Pediatr Oncol 2:333

    Article  CAS  PubMed  Google Scholar 

  9. Barlogie B, Latreille J, Freireich E, Fu CT, Mellard D, Meistrich M, Andreeff M (1980) Characterization of hematological malignancies by flow cytometry. Blood Cells 6:714

    Google Scholar 

  10. Look AT, Williams DL, Brodeur GM, Murphy SB, Dahl GV, Mauer AM (1982) Multiple stemlines in childhood acute lymphoblastic leukemia determined by flow cytometry (FCM). Proc AACR 23:33 (Abstr)

    Google Scholar 

  11. Langermann HJ, Henze G, Wulf M, Riehm HJ (1982) Abschätzung der Tumorzellmasse bei der akuten lymphoblastischen Leukämie im Kindesalter: Prognostische Bedeutung und praktische Anwendung. Klin Pädiatr 194:209

    Article  CAS  PubMed  Google Scholar 

  12. Henze G, Langermann HJ, Fengler R, Brandeis M, Evers KG, Gadner H, Hinderfeld L, Jobke A, Kornhuber B, Lampert F, Lasson U, Ludwig R, Müller-Weihrich S, Neidhardt M, Nessler G, Niethammer D, Rister M, Ritter J, Schaaff A, Schellong G, Stollmann B, Treuner J, Wahlen W, Weinel P, Wehinger H, Riehm J (1982) Bericht über die Therapiestudie BFM 1979/81 zur Behandlung der akuten lymphoblastischen Leukämie bei Kindern und Jugendlichen: Intensivierte Reinduktionstherapie für Patientengruppen mit unterschiedlichem Rezidivrisiko. Klin Pädiatr 194:195

    Article  CAS  PubMed  Google Scholar 

  13. Henze G, Langermann HJ, Kaufmann U, Ludwig R, Schellong G, Stollmann B, Riehm H (1981) Thymic involvement and initial white blood count in childhood acute lymphoblastic leukemia. Am J Ped Hemat Oncol 3:369

    CAS  Google Scholar 

  14. Zante J, Schumann J, Barlogie B, Göhde W, Büchner Th (1976) New preparation and staining procedures for specific and rapid analysis of DNA distributions. Pulse Cytophotometry, 2nd Int. Symp. In: Göhde W, Schumann J, Büchner Th (eds) European Press Ghent 97

    Google Scholar 

  15. Barlogie B, Spitzer G, Hart JS, Johnston DA, Büchner T, Schumann J, Drewinko B (1976) DNA histogram analysis of human hematopoietic cells. Blood 48:245

    CAS  PubMed  Google Scholar 

  16. Wörmann B (1982) Intensivierte Induktionstherapie der akuten myeloischen Leukämie des Erwachsenen: Prognostische Bedeutung einiger zellulärer und zellkinetischer Parameter. Thesis, Münster

    Google Scholar 

  17. Cutler S, Ederer F (1958) Maximum utilisation of the life table method in analyzing survival. J. Chron. Dis. 4:699

    Article  Google Scholar 

  18. Nemenyi P (1963) Distribution-free multiple comparisons. State University of New York, Downstate Medical Center

    Google Scholar 

  19. Barlogie B, Hittelman W, Spitzer G, Hart JS, Trujillo JM, Smallwood L, Drewinko B (1977) Correlation of DNA distribution abnormalities with cytogenetic findings in human adult acute leukemia and lymphoma. Cancer Res 37:4400

    CAS  PubMed  Google Scholar 

  20. Hiddemann W, Wörmann B, Ritter J, Henze G, Langermann HJ, Kaufmann U, Schellong G, Riehm H, Büchner Th (1982) Diagnostik von Aneuploidien bei akuten Leukämien mittels Impulscytophotometrie (ICP): Häufigkeit und klinische Relevanz. Verh Dtsch Ges Inn Med 88:934

    Google Scholar 

  21. Andreeff M, Gee T, Mertelsmann R, McKenzie S, Steinmetz J, Chaganti R, Koziner B, Clarkson B (1980) Biclonal lymphoblastic and myeloblastic acute leukemia. Proc AACR 21:54

    Google Scholar 

  22. Andreeff M, Miller D, Steinherz P, Kempin S, Straus D, Clarkson B (1981) Hypodiploid acute lymphoblastic leukemia (ALL): A rare entity detected and monitored by flow cytometry. Proc AACR 22:44 (Abstr)

    Google Scholar 

  23. Brodeur GM, Williams DL, Look AT, Bowmann WR, Kalwinsky DK (1981) Near-haploid acute lymphoblastic leukemia: A unique subgroup with a poor prognosis? Blood 58:14

    CAS  PubMed  Google Scholar 

  24. Sen L, Borella L (1975) Clinical importance of lymphoblasts with T markers in childhood acute leukemia. N Engl J Med 292:828

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Dept. of Laboratory Medicine and Pathology, Box 609, Mayo Memorial Building, 420 Delaware Street S. E., Minneapolis, Minnesota, 55455, USA

    B. Wörmann

Authors
  1. B. Wörmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. W. Hiddemann
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. Ritter
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. G. Henze
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. H.-J. Langermann
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. U. Kaufmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. G. Schellong
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. H. Riehm
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Th. Büchner
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Medizinische Klinik und Poliklinik der Universität, Albert-Schweitzer-Str. 33, D-4400, Münster, Germany

    Th. Büchner  & W. Hiddemann  & 

  2. Section of Medical Oncology, University of Minnesota School of Medicine, Coleman Leukemia Research and Treatment Center, Box 277 University of Minnesota Hospitals, Minneapolis, Minnesota, 55455, USA

    Clara D. Bloomfield

  3. Department of Oncology and Hematology, Medizinische Universitätsklinik Hamburg-Eppendorf, Martinistr. 52, D-2000, Hamburg 20, Germany

    D. K. Hossfeld

  4. Fachklinik Hornheide, Dorbaumstr. 300, D-4400, Münster, Germany

    J. Schumann

Rights and permissions

Reprints and permissions

Copyright information

© 1985 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Wörmann, B. et al. (1985). Incidence and Prognostic Significance of DNA Aneuploidy in Childhood Acute Lymphoblastic Leukemia. In: Büchner, T., Bloomfield, C.D., Hiddemann, W., Hossfeld, D.K., Schumann, J. (eds) Tumor Aneuploidy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70458-1_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-70458-1_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-15376-4

  • Online ISBN: 978-3-642-70458-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation