Chromosome Findings in Secondary Acute Leukemias

  • D. K. Hossfeld
  • H.-J. Weh
Conference paper


In 1970 several papers were published in the international medical literature pointing to an increased incidence of leukemia particularly in patients who had received chemotherapy because of multiple myeloma. In the same year, while working in the Roswell Park Memorial Institute in Buffalo, USA, the senior author, had the opportunity to analyse the chromosomes of leukemic cells of four such patients. Chromosome banding techniques were not available at that time. Nevertheless a number of remarkable findings became apparent: all cases were revealed to have profound numerical and structural anomalies, 3 out of 4 cases were hypodiploid, loss of chromosomes of groups 4–5 and 17–18 was noted in 2 cases, double minutes were seen in 2 cases [1]. During the following years more than 250 additional cases have been investigated; our early observations were confirmed, but more importantly, the introduction of banding techniques increased their significance considerably.


Multiple Myeloma Chronic Myeloid Leukemia Acute Leukemia Polycythemia Vera Roswell Park Memorial Institute 
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  1. 1.
    Hossfeld DK, Holland JF, Cooper RG, Ellison RR (1975) Chromosome studies in acute leukemias developing in patients with multiple myeloma. Cancer Res 35:2808–2813PubMedGoogle Scholar
  2. 2.
    Matsuzaki H, Yamaguchi K, Hara H, Mitsuya H, Kawano F, Araki K, Tanaka R, Kishimoto S (1983) Simultaneous occurrence of acute myelogenous leukaemia and multiple myeloma without previous chemotherapy. Scand J Haematol 30:278–286PubMedCrossRefGoogle Scholar
  3. 3.
    Thiagarajan P (1979) Simultaneous presentation of multiple myeloma and acute leukemia in the absence of previous chemotherapy — Report of a case. M Sinai J Med (N.Y.) 46:360–363Google Scholar
  4. 4.
    Sandberg AA, Abe S, Kowalczyk JR, Zedgenidze A, Takeuchi J, Kakati S (1982) Chromosomes and causation of human cancer and leukemia: L. cytogenetics of leukemias complicating other diseases. Cancer Genet Cytogenet 7:95–136PubMedCrossRefGoogle Scholar
  5. 5.
    The Fourth International Workshop on Chromosomes in Leukemia, 1982 (1984) Cancer Genet Cytogenet 11:249–360Google Scholar
  6. 6.
    Mitelman F, Nilsson PG, Brandt L, Alimena G, Gastaldi R, Dallapiccola B (1981) Chromosome pattern, occupation, and clinical features in patients with acute nonlymphocytic leukemia. Cancer Genet Cytogenet 4:197–214PubMedCrossRefGoogle Scholar
  7. 7.
    Golomb HM, Alimena G, Rowley JD, Vardiman JW, Testa JR, Sovik C (1982) Correlation of occupation and karyotype in adults with acute nonlymphocytic leukemia. Blood 60:404–411PubMedGoogle Scholar
  8. 8.
    Van den Berghe H, Cassiman J-J, David G, Fryns J-P, Michaux J-L, Sokal G (1974) Distinct haematological disorder with deletion of long arm of No. 5 chromosome. Nature 251:437–438PubMedCrossRefGoogle Scholar
  9. 9.
    Otter M, Palmer CG, Baehner RL (1979) Sister chromatid exchange in lymphocytes from patients with acute lymphoblastic leukemia. Human Genet 52:185–192Google Scholar
  10. 10.
    Miller RC, Hill RB, Nichols WW, Meadows AT (1978) Acute and long-term cytogenetic effects of childhood cancer chemotherapy and radiotherapy. Cancer Res 38:3241–3246PubMedGoogle Scholar
  11. 11.
    Robison LL, Arthur DC, Ball DW, Danzl TJ, Nesbit ME (1982) Cytogenetic studies of long-term survivors of childhood acute lymphoblastic leukemia. Cancer Res 42:4289–4292PubMedGoogle Scholar
  12. 12.
    Inoue S, Brown L, Ravindranath Y, Ottenbreit MJ (1982) Normal sister chromatid exchange frequency in long-term survivors with acute leukemia. Cancer Res 42:2906–2908PubMedGoogle Scholar
  13. 13.
    Gebhart E, Lösing J, Wopfner F (1980) Chromosome studies on lymphocytes of patients under cytostatic therapy. I. Conventional chromosome studies in cytostatic interval therapy. Human Genet 55:53–63CrossRefGoogle Scholar
  14. 14.
    Gebhart E, Windolph B, Wopfner F (1980) Chromosome studies on lymphocytes of patients under cytostatic therapy. II. Studies using the BUDR-labelling technique in cytostatic interval therapy. Human Genet 56:157–167CrossRefGoogle Scholar
  15. 15.
    Nowell P, Glick JH, Bucolo A, Finan J, Creech R (1981) Cytogenetic studies of bone marrow in breast cancer patients after adjuvant chemotherapy. Cancer 48:667–673PubMedCrossRefGoogle Scholar
  16. 16.
    Patil SR, Corder MP, Jochimsen PR, Dick FR (1980) Bone marrow chromosome abnormalities in breast cancer patients following adjuvant chemotherapy. Cancer Res 40:4076–4080PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • D. K. Hossfeld
    • 1
  • H.-J. Weh
    • 1
  1. 1.Dept. Oncology and HematologyMed. Univ. Klinik Hamburg-EppendorfHamburg 20Germany

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