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The Clinical Usefulness of Chromosome Abnormalities in Acute Leukemia

  • Conference paper
Tumor Aneuploidy

Abstract

Considerable excitement has been generated recently by newer techniques for the cytogenetic analysis of acute leukemia. Older, less precise, methods of analysis suggested that approximately 50% of patients with either ANLL or ALL had karyotype abnormalities in the leukemic cell population. However, it was thought that the chromosomal abnormalities detected were random rather than specific changes. The application of banding techniques, primarily quinacrine fluorescence (Q) and Giemsa (G), has permitted more detailed characterization of structural rearrangements within chromosomes. This has meant that gross morphologic alterations in the shape of the chromosome did not have to be present for abnormalities to be detected. It is now possible to precisely identify individual chromosomes despite deletions and translocations. Moreover, for unknown reasons, culture techniques, with or without methotrexate synchronization, increase relative to direct techniques the yield of mitoses containing the clonal chromosome abnormality, at least in ANLL (Berger et al. 1980a; Carbonell et al. 1979; Knuutila et al. 1980, 1981; Waghray et al. 1981; Fitzgerald et al. 1982; Hagemeijer et al. 1979; Yunis et al. 1981). By applying banding and various culture as well as direct techniques, and by obtaining adequate samples pretreatment of bone marrow, nonrandom chromosome changes can now be identified in the majority of patients with acute leukemia.

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Authors and Affiliations

  1. Section of Medical Oncology, University of Minnesota School of Medicine, Coleman Leukemia Research and Treatment Center, Box 277, University of Minnesota Hospitals, Minneapolis, Minnesota, 55455, USA

    C. D. Bloomfield

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  1. C. D. Bloomfield
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Editors and Affiliations

  1. Medizinische Klinik und Poliklinik der Universität, Albert-Schweitzer-Str. 33, D-4400, Münster, Germany

    Th. Büchner  & W. Hiddemann  & 

  2. Section of Medical Oncology, University of Minnesota School of Medicine, Coleman Leukemia Research and Treatment Center, Box 277 University of Minnesota Hospitals, Minneapolis, Minnesota, 55455, USA

    Clara D. Bloomfield

  3. Department of Oncology and Hematology, Medizinische Universitätsklinik Hamburg-Eppendorf, Martinistr. 52, D-2000, Hamburg 20, Germany

    D. K. Hossfeld

  4. Fachklinik Hornheide, Dorbaumstr. 300, D-4400, Münster, Germany

    J. Schumann

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© 1985 Springer-Verlag Berlin Heidelberg

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Bloomfield, C.D. (1985). The Clinical Usefulness of Chromosome Abnormalities in Acute Leukemia. In: Büchner, T., Bloomfield, C.D., Hiddemann, W., Hossfeld, D.K., Schumann, J. (eds) Tumor Aneuploidy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70458-1_2

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  • DOI: https://doi.org/10.1007/978-3-642-70458-1_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-15376-4

  • Online ISBN: 978-3-642-70458-1

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