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Properties of Cytoplasmic Transmitters of Excitation in Vertebrate Rods and Evaluation of Candidate Intermediary Transmitters

  • E. N. PughJr.
  • W. H. Cobbs
Conference paper
Part of the Dahlem Workshop Reports book series (DAHLEM, volume 34)

Abstract

A cytoplasmically diffusing substance or transmitter must carry the message of excitation from the vertebrate rod disk membrane to the rod plasma membrane, there effecting a decrease in the light-sensitive membrane current. A number of general properties of the transmitter molecule that communicates excitation to the rod plasma membrane either can be deduced from or are strongly constrained by facts of rod physiology. Here we analyze seven general properties of an excitational transmitter: a) transmitter sign (positive or negative concentration change induced by light); b) multi-order sequence of events in production/ destruction; c) numerical gain in production; d) restricted longitudinal diffusion along the outer segment; e) buffering effects on gain and diffusion coefficient; f) limited transmitter lifetime; and g) linearity of transmitter production/reduction with light intensity. Although only cGMP and calcium have been hypothesized to be the molecule communicating excitation to the plasma membrane, other substances have been hypothesized to serve as intermediary transmitters in excitation. We examine the following five intermediary transmitter candidates in the light of the seven general properties: (i) G-protein; (ii) protons; (iii) 5′GMP; (iv) cGMP-dependent protein kinase; and (v) inositol-1, 4, 5-trisphosphate.

Keywords

Outer Segment Disk Membrane Longitudinal Diffusion Transmitter Candidate cGMP Hydrolysis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Dr. S. Bernhard, Dahlem Konferenzen, Berlin 1986

Authors and Affiliations

  • E. N. PughJr.
    • 1
  • W. H. Cobbs
    • 2
  1. 1.Dept. of PsychologyUniversity of PennsylvaniaPhiladelphiaUSA
  2. 2.Dept. of NeurologyUniversity of Pennsylvania Medical SchoolPhiladelphiaUSA

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