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DMSO pp 101-114 | Cite as

Eine neue Therapie der Nagelpsoriasis mit einer Kombination aus 5-Fluorouracil (5-FU) und Dimethylsulfoxid (DMSO)

  • M.-W. Kleine

Zusammenfassung

Die Psoriasis vulgaris ist eine in westlichen Ländern sehr verbreitete Krankheit. Etwa 2% der Bevölkerung leiden an ihr mehr oder weniger stark (Braun-Falco 1984). Sie ist damit etwa so häufig wie der Diabetes mellitus (Schoeffling 1984). Ihre Ausprägung kann von einzelnen, sehr kleinen Herden bis zu lebensbedrohlichen Formen (z.B. Typ Zumbusch) reichen.

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Literatur

  1. Abraham D, Feuerman EJ (1978) Local treatment of psoriatic nails with 5-fluorouracil. J Isr Med Assoc 94: 116ffGoogle Scholar
  2. Achten G (1968) Normale Histologie und Histochemie des Nagels. In: Jadassohn J (Hrsg) Handbuch der Haut und Geschlechtskrankheiten. Springer, Berlin Heidelberg New YorkGoogle Scholar
  3. Baker H, Wilkinson DS (1979) Psoriais. In: Rook A, Wilkinson DS, Ebling FJG (eds) Textbook of dermatology, 3rd edn, vol 2. Blackwell, OxfordGoogle Scholar
  4. Bandmann HJ, Kleine MW (1983) Psoriasistherapie — Behaarter Kopf, Nägel und intertriginöse Räume. In: Braun-Falco O, Burg G (Hrsg) Fortschritte der praktischen Dermatologie und Venerologie, Bd 10. Springer, Berlin Heidelberg New YorkGoogle Scholar
  5. Baran R (1984) Diseases of the nails and their management. Blackwell, OxfordGoogle Scholar
  6. Berger I, Hauthal H (1971) Dimethylsulfoxid in Medizin und Pharmakologie. In: Martin D, Hauthal H (Hrsg)) Dimethylsulfoxid. Akademie, BerlinGoogle Scholar
  7. Braun-Falco O (1984) Dermatologie und Venerologie, 3. Aufl. Springer, Berlin Heidelberg New York TokyoGoogle Scholar
  8. Brown JH (1982) Dimethyl sulfoxide (DMSO) — a unique therapeutic entity. Aviat Space Environ Med 82: 82–88Google Scholar
  9. Calvert HT, Smith MA, Wells RS (1963) Psoriasis and the nailsn. Br J Dermatol 75: 415PubMedCrossRefGoogle Scholar
  10. Cohen JL, Stoughton RB (1974) Penetration of 5-fluorouracil on normal skin. J Invest. Dermatol 62: 507PubMedCrossRefGoogle Scholar
  11. Cortesse TA (1971) DMSO in dermatology. In: Jacob SW (ed) Dimethyl sulfoxide; vol 1, Basic concepts of DMSO. Dekker, New YorkGoogle Scholar
  12. Dillaha CJ, Jansen GT (1963) Selective cytotoxic effects of topical 5 fluorouracil. Arch Dermatol 88: 247PubMedGoogle Scholar
  13. Dillaha CJ, Jansen T, Honeycutt MW et al. (1965) Further studies on topical 5-fluorouracil, Arch Dermatol 92: 410PubMedCrossRefGoogle Scholar
  14. Falkson G, Schulz EJ (1962) Skin changes in patients treated with 5 fluorouracil. Br J Dermatol 74: 229PubMedCrossRefGoogle Scholar
  15. Forth W (1980) Allgemeine und spezielle Pharmakologie und Toxikologie, 3. Aufl, Bibliographisches Institut, MannheimGoogle Scholar
  16. Fredriksson T (1974) Topically applied fluorouracil in the treatment of psoriatic nails. Arch Dermatol 110: 735PubMedCrossRefGoogle Scholar
  17. Goette DK (1981) Topical chemotherapy with 5-fluorouracil. Am Acad Dermatol 6(4): 633CrossRefGoogle Scholar
  18. Goodman Gilman A, Goodman LS, Gilman A (1980) The pharmacological basis of therapeutics, 6th edn, Macmillan, New YorkGoogle Scholar
  19. Heidelberger C, Chaudhuri NK, Danneburg P, et al. (1957) Fluorinated pyrimidines: a new class of tumor-inhibitory compounds. Nature 179: 663PubMedCrossRefGoogle Scholar
  20. Heidelberger C, Ghobar A, Baker RK, et al. (1960) Studies on fluorinated pyrimidines. X. In vivo studies on tumor resistance. Cancer Res 20: 897PubMedGoogle Scholar
  21. Herschler RT, Jacob SW (1980) The case of dimethyl sulfoxide. In: Lasagna L (ed) Controversis in Therapeutic. Saunders, PhiladelphiaGoogle Scholar
  22. Jacob SW, Bischel M, Herschler RT (1964) Dimethyl-sulfoxide: (I) A new concept in pharmacotherapy; (II) Effects on the permability of biologic membranes. Curr Ther Res vol 6, p 134PubMedGoogle Scholar
  23. Klein E, Milgrom H, et al. (1962) Tumors of the skin; I.: Effects of local use as cytostatic agents. Skin 1: 81PubMedGoogle Scholar
  24. Kligman AM (1965) Topical pharmacology and toxicology of dimethyl sulfoxide, part I a. II. J Am Med Assoc 193Google Scholar
  25. Kolb KH, Jaenicke G, Kramer M, Schulze PE (1967) Absorption, distribution and elimination of labeled dimethyl sulfoxide in man and animals. Ann NY Acad Sci 141: 85PubMedCrossRefGoogle Scholar
  26. Lane-Brown MM (1980) Skalp and nail psoriasis. Med J Aust 26: 82Google Scholar
  27. Luger A (1977) Neuere Aspekte der Psoriasistherapie. Wien Med Wochenschr 24: 727Google Scholar
  28. Maibach HI, Feldman RJ (1967) The effect of percutaneous penetration of hydrocortisone and testosterone in man, Ann NY Acad Sci 141: 423PubMedCrossRefGoogle Scholar
  29. Merckle GmbH (1984) Chemisch-Analytisches Labor. BlaubeurenGoogle Scholar
  30. Murkherjee KL, Curreri AR, Javid M et al. (1963) Studies on Fluorinated Pyrimidines; XVII, tissue distribution of 5-fluorouracil-2C14 and 5-fluoro-2-desoxyuredine in cancer patients. Cancer Res 23: 67Google Scholar
  31. Rassner G (1980) Psoriasis. In: Körting GW (Hrsg) Dermatologie in Praxis und Klinik Bd II. Thieme, StuttgartGoogle Scholar
  32. Rain TJ (1973) Direct observations of blood vessels in the superficial microvascular system of the skin. In: Jarrett A (ed) The physiology and pathophysiology of the skin, vol 2. Academic Press, LondonGoogle Scholar
  33. Roth SI (1967) Hair and nail. In: Zelickson AS (ed) Ultrastructure of normal and abnormal skin. Kimpton, LondonGoogle Scholar
  34. Samman P (1978) The nails in disease, 3rd edn, Heinemann, LondonGoogle Scholar
  35. Schoeffling K (1984) Epidemiologie des Diabetes mellitus In: Mehnert H (Hrsg) Diabetologie in Klinik und Praxis, 2. Aufl. Thieme, StuttgartGoogle Scholar
  36. Shelley W (1972) Onycholysis due to topical 5-fluorouracil. Acta Dermatol Venerol 52: 320Google Scholar
  37. Sobotta J, Becher H (1962) Atlas der Anatomie des Menschen, Teil III. Urban & Schwarzenberg, MünchenGoogle Scholar
  38. Stoughton RB, Fritsch W (1964) Influence of dimethyl sulfoxide (DMSO) on human percutaneous absorption. Arch Dermatol 90: 512PubMedCrossRefGoogle Scholar
  39. Tsuji T, Sugai T (1972) Topically adminestred fluorouracil in psoriasis. Arch Dermatol 105: 208PubMedCrossRefGoogle Scholar
  40. Valeriote F, Santelli G (1984) 5-fluorouracil. Pharmac Ther 24: 107CrossRefGoogle Scholar
  41. Waldeyer A (1970) Anatomie des Menschen, Teil II, 6. Aufl. de Gruyter, BerlinGoogle Scholar
  42. Wassilew SW (1981) Die Behandlung von Viruskrankheiten der Haut. Ther Woche 31: 6362Google Scholar
  43. Zaias N (1963) Embryology of the human nail. Arch Dermatol 87: 37PubMedGoogle Scholar
  44. Zaias N (1969) Psoriasis of the nail. A clinical-pathology study. Arch Dermatol 99: 567PubMedCrossRefGoogle Scholar
  45. Zelickson AS, Mottaz J, Weiss LW (1975) Effects of topical fluorouracil on normal skin. Arch Dermatol 111: 1301PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

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  • M.-W. Kleine

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