Advertisement

Complement

  • Wilmar Dias Da Silva

Abstract

Pfeiffer and Issaeff observed in 1894 that cholera vibrios disintegrated when injected into the peritoneal cavities of previously immunized guinea pigs. Bordet demonstrated that the microorganisms also were lysed within minutes when placed in vitro in the presence of serum obtained from immunized animals; however, if the serum was heated to 56 °C for 30 min, or simply allowed to age for a few days, it lost its lytic activity even though the antibodies were preserved. The addition of fresh serum obtained from nonimmune animals restored the lytic activity of serum. This experiment demonstrated that the bacteriolytic action of serum of immunized animals depended upon two factors, one (the antibody) specific and thermostabile, and another that was thermolabile and nonspecific, existing in immune serum as well as in normal serum.

Keywords

Sialic Acid Complement System Complement Component Decay Accelerate Factor Arthus Reaction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Alper, CH, Rosen, FS (1971) Genetic aspects of the complement system. Adv Immunol 14: 252Google Scholar
  2. Bing, DH (1979) The chemistry and physiology of the human plasma proteins. Pergamon Press, New YorkGoogle Scholar
  3. Fearon, DT (1979) Activation of the alternative path-way. Critical Reviews in Immunology 1 (4): 1–32PubMedGoogle Scholar
  4. Gewurz, H (1971) The immunologic role of complement. In: Good RA, Fisher, DW (eds) Immunobiology. Sinauer, StamfordGoogle Scholar
  5. Hugli, TE (1981) The structural basis for anaphylatoxin and chemotactic functions of C3a, C4a and C5a. Critical Reviews in Immunology 1 (4): 324–336Google Scholar
  6. Humphrey, JH, Dourmashkin, RR (1969) The lesions in cell membranes caused by complement. Adv Immunol 11: 75PubMedCrossRefGoogle Scholar
  7. Lachman PL (1979) Complement. In: Sela E (ed) The antigen. Academic, New YorkGoogle Scholar
  8. Lepow, IH (1965) Serum complement and properdin. In: Santer M (ed) Immunological diseases. Little, Brown, BostonGoogle Scholar
  9. Lepow, IH et al. (1968) Nature and biological properties of human anaphylatoxin. In: Austen KF, Becker EL (eds) Biochemistry of acute allergic reactions. Blackwell, OxfordGoogle Scholar
  10. Mayer, MM (1961) Complement and complement fixation. In: Kabat EA, Mayer MM (eds) Experimental immunochemistry. Thomas, SpringfieldGoogle Scholar
  11. Mayer MM (1973) The complement system. Sci Am 229: 54PubMedCrossRefGoogle Scholar
  12. Medicus, RG, Schreiber, RD, Götze, OJ, Müller-Eberhard, H J (1976) A molecular concept of the properdin pathway. Proc Natl Acad Sci 73: 612PubMedCrossRefGoogle Scholar
  13. Müller-Eberhard, H (1966) A molecular concept of immune cytolysis. Arch Path 82: 205PubMedGoogle Scholar
  14. Müller-Eberhard, H (1969) Complement. Ann Rev Biochem 38: 389PubMedCrossRefGoogle Scholar
  15. Müller-Eberhard, H (1975) Complement. Ann Rev Biochem 44: 697PubMedCrossRefGoogle Scholar
  16. Müller-Eberhard, HJ, Schreiber, RD (1980) Molecular biology and chemistry of the alternate pathway of complement. Adv Immunol 29: 2Google Scholar
  17. Müller-Eberhard, HJ, Hoffmann, LG, Mayer, M (1977) Complement, Chap 17. In: Williams CA, Chase MW (eds) Methods in Immunology and Immunochemistry, vol IV. Academic PressGoogle Scholar
  18. Spitzer, RE (1977) The complement system. Pediatric Clinics of North America 24: 341PubMedGoogle Scholar
  19. Ward, PA (1971) The role of complement in inflammation and hypersensitivity. In: Movat, HZ (ed) Inflammation and hypersensitivity. Harper and Row, New YorkGoogle Scholar
  20. Ward, PA, Becker EL (1977) Biology of Leukotaxis. Rev Physiol Biochem Pharmacol 77: 125–148PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • Wilmar Dias Da Silva

There are no affiliations available

Personalised recommendations