In Vitro Models for Acute Toxicity Testing

  • J. M. Frazier
Conference paper


The basic problem faced by the pharmaceutical industry is to provide efficacious products which are safe for use by the intended consumer. Literally hundreds of new products and formulations are developed each year which must be evaluated for all aspects of potential toxicity. The need for simple, rapid and reliable test methods is obvious. The potential of in vitro tests to meet these needs is equally obvious. The advantages of in vitro tests over conventional whole animal tests include significant reductions in cost, time and physical resources. In addition, in vitro tests have the advantage of addressing the concerns of animal welfare advocates by reducing and/or eliminating the utilization of live animals in toxicity tests.


Acute Toxicity Animal Test Dynamic Phase Acute Toxicity Testing Potential Index 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • J. M. Frazier

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