Use of In Vivo and In Vitro Test Systems as Predictors of the Cutaneous Irritancy of Synthetic Detergents (Syndets)
There have been several attempts to develop laboratory or animal based test systems [6, 8, 12, 14] which might prove useful either in the prediction of irritancy of synthetic detergents (syndets) in humans or in discriminating between different syndets. The degrees of success of these methods have been variable and the search continues for more suitable techniques.
KeywordsFormalin Toxicity Torque Interferon Dermatol
Unable to display preview. Download preview PDF.
- 2.Bronaugh RL, Maibach HI (1982) Evaluation of skin irritation: correlation between animals and humans. In: Kligman AM, Leydon JJ (eds) Safety and efficacy of topical drugs and cosmetics. Grune & Stratton, New York, pp 51–62Google Scholar
- 3.Conover WJ (1980) Practical non parametric statistics, 2nd edn. John Wiley & Sons, New York, pp 299–303Google Scholar
- 5.Frosch PJ (1982) Irritancy of soaps and detergent bars. In: Frost P (ed) Principles of cosmetics for the dermatologist. CV Mosby Co, St Louis, pp 5–12Google Scholar
- 12.Prottey C, Ferguson T (1975) Factors which determine the skin irritation potential of soaps and detergents. J Soc Cosmet Chem 26: 29–46Google Scholar