Comparative Study of the Keratin Polypeptide Profiles in Human and in Pig Hyperkeratotic Scabies
Increased numbers of patients with hyperkeratotic (or Norwegian) scabies have been reported in the literature in recent years. Various environmental and endogeneous factors are known to be associated with the disease . An animal model could be useful to evaluate the relative importance of each of these factors by modifying them one by one and could provide deeper insight into the disturbed keratinization process which is the clinical characteristic feature of this parasitic disease. As there is strong evidence now that fibrous proteins of different physicochemical properties are intimately associated with the epidermal cell differentiation process [2, 19, 20] and that polypeptide composition of the fibrous protein is subjected to environmental influences, we were interested in evaluating the electrophoretic patterns of the fibrous proteins in scales of human and pig hyperkeratotic scabies.
KeywordsAlbumin Electrophoresis Polypeptide Trypsin Cyclophosphamide
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