Abstract
There is a great variety of follicular diseases in man related to the pilosebaceous apparatus. They include excessive production of sebum, accumulation of keratinized material (comedones) in the follicular infundibula, and inflammatory lesions (papules, pustules, nodules). Clinical expressions of these diseases are seborrhea, acne vulgaris, contact acne due to industrial compounds or toiletries to name but a few [21]. Models to study follicular diseases can be divided into two, the keratinizing and the sebaceous gland ones. In the keratinizing models etiopathogenesis of follicular diseases can be studied as well as harzardous compounds leading to follicular impactions as in the case with some industrial compounds, cosmetic products or even acne remedies. In the sebaceous gland models etiopathogenesis of diseases associated with seborrhea can be investigated as well as compounds directed against the production of sebum (sebum-suppressive agents). It is important to realize the scope of these models and also to be aware of their shortcomings. This is elucidated by the differentiation of, e.g., comedogenicity versus irritancy, or sebum suppression versus irritancy. Asking the right question in the proper models helps to avoid controversies.
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Plewig, G. (1986). Models to Study Follicular Diseases. In: Marks, R., Plewig, G. (eds) Skin Models. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70387-4_2
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DOI: https://doi.org/10.1007/978-3-642-70387-4_2
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