Abstract
Topical steroid bioassays are the most refined, sophisticated bioassays used to test and develop skin preparations [13]. In particular, the blanching or vasoconstrictor assay may be employed to screen new steroids for clinical efficacy and also to determine the bioavailability of steroids from topical formulations; thus, we can use the test not only to evaluate the intrinsic activity of a steroid for correlation with possible clinical antiinflammatory action, but also to investigate fundamental bipharmaceutical relationships. In the present context, by bioavailability we mean the relative absorption efficiency for a drug as determined by the release of the steroid from its formulation and its subsequent penetration through the stratum corneum and viable epidermis into the dermis to produce the characteristic blanching effect.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Altmeyer P, Zaun H (1976) Reflexphotometric determinations of vasoconstriction after topical application of steroids. V. Vasoconstriction phenomenon and tachyphylaxis after repeated steroid application. Arch Derm Res 255: 51–56
Barry BW (1976) Bioavailability of topical steroids. Dermatologica 152 suppl 1: 47–65
Barry BW (1983) Dermatological formulations. Percutaneous Absorption. Dekker, New York Basel
Barry BW, Brace AR (1975) Vasoconstrictor activities of some novel synthetic steroids in alcoholic solution. J Invest Dermatol 64: 418–422
Barry BW, Southwell D, Woodford R (1984) Optimisation of bioavailability of topical steroids: penetration enhancers under occlusion. J Invest Dermatol 82: 49–52
Barry BW, Woodford R (1974) Comparative bioavailability of proprietary topical corticosteroid preparations; vasoconstrictor assays on thirty creams and gels. Br J Dermatol 91: 323–338
Barry BW, Woodford R (1975) Comparative bioavailability of proprietary topical corticosteroid preparations: vasoconstrictor assays on thirty-one ointments. Br J Dermatol 93: 563–571
Barry BW, Woodford R (1976) Proprietary hydrocortiscone creams. Vasoconstrictor activities and bioavailabilities of six preparations. Br J Dermatol 95: 423–425
Barry BW, Woodford R (1977) Vasoconstrictor activities and bioavailabilities of seven proprietary corticosteroid creams assessed using a non-occluded multiple dosage regimen; clinical implications. Br J Dermatol 97: 555–560
Barry BW, Woodford R (1978) Activity and bioavailability of topical steroids. In vivo/in vitro correlations for the vasoconstrictor test. J Clin Pharm 3: 43–65
Duvivier A, Stoughton RB (1975) Tachyphylaxis to the action of topically applied corticosteroids. Arch Dermatol 111: 581–583
Duvivier A, Stoughton RB (1976) Acute tolerance to effects of topical glucocorticosteroids. Br J Dermatol 94 suppl 12: 25–32
Haleblian JK (1976) Bioassays used in development of topical dosage forms. J Pharm Sci 65: 1417–1436
Maibach HI, Stoughton RB (1973) Topical corticosteroids. Med Clin North Am 57: 12531264
McKenzie AW, Stoughton RB (1962) Method for comparing percutaneous absorption of steroids. Arch Dermatol 86: 608–610
Schaefer H, Zesch A, Stüttgen G (1982) Skin permeability. Springer, Berlin Heidelberg New York, pp 690–697
Schlagel CA (1972) Penetration and action of glucocorticoids. In: Montagna W, Van Scott EJ, Stoughton RB (eds) Advances in biology of skin, vol XII: Pharmacology and the skin. AppetonCentury-Crofts, New York, pp 339–356
Senter TP, Stimpson DH, Charles G (1983) Comparison of two therapeutic regimens using the same topical corticoid for stable psoriasis. Western J Med 139: 657–662
Sudilovsky A, Muir JG, Bocobo FC (1981) A comparison of single and multiple application of halcinonide cream. Intern Soc Trop Dermatol 20: 609–613
Woodford R, Barry BW (1977) Bioavailability and activity of topical coticosteroids from a novel drug delivery system, the aerosol quick-break foam. J Pharm Sci 66: 99–103
Woodford R, Barry BW (1982) Optimisation of topical steroids: thermodynamic control. J Invest Dermatol 79: 388–391
Woodford R, Barry BW (1984) Alphaderm cream (1% hydrocortisone plus 10% urea): investigation of vasoconstrictor activity, bioavailability and application regimens in human volunteers. Curr Ther Res 35: 759–767
Woodford R, Haigh JM, Barry BW (1983) Possible dosage regimens for topical steroids, assessed by vasoconstrictor assays using multiple applications. Dermatologica 166: 136–140
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Barry, B.W., Woodford, R. (1986). The Vasoconstrictor Test as a Model for Developing Topical Formulations. In: Marks, R., Plewig, G. (eds) Skin Models. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70387-4_13
Download citation
DOI: https://doi.org/10.1007/978-3-642-70387-4_13
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-70389-8
Online ISBN: 978-3-642-70387-4
eBook Packages: Springer Book Archive