Abstract
It is generally accepted that the stratum corneum acts as an effective barrier to the penetration of a wide variety of substances. When sufficient quantities of a toxic agent pass this barrier, epidermal or dermal damage may result or the agent may pass into the blood stream resulting in possible damage elsewhere in the body.
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References
Banks-Schlegel S, Green H (1980) Formation of epidermis by serially cultivated human epidermal cells transplanted as an epithelium to athymic mice. Transplantation 29: 308–313
Bartek MJ, La Budde JA, Maibach HI (1972) Skin permeability in vivo: comparison in rat, rabbit, pig and man. J Invest Dermatol 58: 114–123
Briggaman RA, Wheeler CE (1976) Lamellar ichthyosis: long-term graft studies on congenitally athymic nude mice. J Invest Dermatol 67: 567–572
Burbach JPE (1957) Bijdrage tot de kennis van blaarvorming in de huid. Thesis, University of Amsterdam, Amsterdam
Duprez A (1979) Etude macroscopique et microscopique de la reprise des greffes de peaux de cadavres humains chez la souris athymique nu/nu. C R Hebd Seances Acad Sci Ser D Sci Nat 288: 1505–1508
Duprez A (1980) Greffes chez la souris athymique nu/nu de peaux humaines porteuses de naevi ou de naevocarcinomes superficiels: étude macroscopique et microscopique. C R Hebd Seances Acad Sci Ser D Sci Nat 290: 461–464
Elskamp DMW, Verzantvoort CAM, Cohen EM (1973) Skin penetration and decontamination in man and animals. MBL-report 1973–9
Fraki JE, Briggaman RA, Lazarus GS (1983) Transplantation of psoriatic skin onto nude mice. J Invest Dermatol 80: 31s - 35s
Griesemer LD, Blank IH, Gould E (1958) The penetration of an anticholinesterase agent (sarin) into skin. III. A method for studying the rate of penetration into the skin of the living rabbit. J Invest Dermatol 31: 255–258
Hunziker N, Feldmann RJ, Maibach HI (1978) Animal models of percutaneous penetration: Comparison in Mexican hairless dogs and man. Dermatological 156: 79–88
Johnson CD, Russel RL (1975) A rapid, simple radiometric assay for cholinesterase, suitable for multiple determinations. Anal Biochem 64: 229–238
Krueger GG, Manning DD, Malouf J, Ogden B (1975) Long-term maintenance of psoriatic human skin on congenitally athymic (nude) mice. J Invest Dermatol 64: 307–312
Manning DD, Reed ND, Schaffer CF (1973) Maintenance of skin xenografts of widely divergent phylogenetic origin on congenitally athymic (nude) mice. J Exp Med 138: 488–494
Middleton MC (1980) Evaluation of cellular injury in skin utilizing enzyme activities in suction blister fluid. J Invest Dermatol 74: 219–223
Reed ND, Manning DD (1973) Long-term maintenance of normal human skin on congenitally athymic (nude) mice. Proc Soc Exp Biol Med 143: 350–353
Rygaard J (1974) Skin grafts in nude mice. 3. Fate of grafts from man and donors of other taxonomic classes. Acta Path Microbiol Scand Section A 82: 105–112
Rygaard J (1974) Skin grafts in nuce mice. 1. Allografts in nude mice of three genetic backgrounds (Balb/c, C3H, C57/Bl). Acta Path Microbiol Scand Section A 82: 80–92
Weger N (1980) Alkylantien Vergiftungen. In: Rebentisch E (ed) Wehrmedizin. Urban und Schwarzenberg, München, pp 261–266
Wester RC, Maibach HI (1983) In vivo percutaneous absorption. In: Marzulli FN, Maibach HI (eds) Dermatotoxicology. Hemisphere Publishing Corporation, Washington New York London, pp 131–146
Yuspa SH (1979) Maintenance of human skin on nude mice for studies of chemical carcinogenesis. Cancer Lett 6: 301–310
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© 1986 Springer-Verlag Berlin Heidelberg
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van Genderen, J., Wolthuis, O.L. (1986). New Models for Testing Skin Toxicity. In: Marks, R., Plewig, G. (eds) Skin Models. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70387-4_11
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DOI: https://doi.org/10.1007/978-3-642-70387-4_11
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-70389-8
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