Coordinated Expression of c-myc Gene and a Multigenic Set May Modulate the Malignant Phenotype in Human Haemopoietic Cell Lines

  • J. Harel
  • N. Hanania
  • D. Shaool
  • D. Zeliszewski
  • M. Castagna
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 29)

Abstract

We previously showed that about 2000 non repeated DNA sequences of 3 Kbs each, designated as tumor-activated DNA (Ta- DNA), are transcriptionally activated in human neoplasias [1, 2]. A growing body evidence supports the concept that oncogenic transformation may depend on abnormal activation of cellular oncogenes (see general reviews [3, 4]), resulting in gene amplification, chromosomal rearrangements [5], or point mutations [6] and possibly involving cooperative oncogenes [7].

Keywords

Albumin Lymphoma DMSO Leukemia Citrate 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • J. Harel
  • N. Hanania
  • D. Shaool
  • D. Zeliszewski
  • M. Castagna

There are no affiliations available

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