Coordinated Expression of c-myc Gene and a Multigenic Set May Modulate the Malignant Phenotype in Human Haemopoietic Cell Lines
We previously showed that about 2000 non repeated DNA sequences of 3 Kbs each, designated as tumor-activated DNA (Ta- DNA), are transcriptionally activated in human neoplasias [1, 2]. A growing body evidence supports the concept that oncogenic transformation may depend on abnormal activation of cellular oncogenes (see general reviews [3, 4]), resulting in gene amplification, chromosomal rearrangements , or point mutations  and possibly involving cooperative oncogenes .
KeywordsRetinoic Acid Raji Cell Differentiation Inducer Cellular Oncogene Namalwa Cell
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