Coordinated Expression of c-myc Gene and a Multigenic Set May Modulate the Malignant Phenotype in Human Haemopoietic Cell Lines

  • J. Harel
  • N. Hanania
  • D. Shaool
  • D. Zeliszewski
  • M. Castagna
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 29)


We previously showed that about 2000 non repeated DNA sequences of 3 Kbs each, designated as tumor-activated DNA (Ta- DNA), are transcriptionally activated in human neoplasias [1, 2]. A growing body evidence supports the concept that oncogenic transformation may depend on abnormal activation of cellular oncogenes (see general reviews [3, 4]), resulting in gene amplification, chromosomal rearrangements [5], or point mutations [6] and possibly involving cooperative oncogenes [7].


Retinoic Acid Raji Cell Differentiation Inducer Cellular Oncogene Namalwa Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Hanania N, Shaool D, Poncy C, Harel J (1981) Proc Natl Acad Sei USA 78: 6504–6508CrossRefGoogle Scholar
  2. 2.
    Hanania N, Shaool D, Harel J, Wiels J, Tursz T(1983) EMBO J 2: 1621–1624Google Scholar
  3. 3.
    Cooper GM (1982) Science 218: 801–807CrossRefGoogle Scholar
  4. 4.
    Weinberg RA (1982) Adv Cancer Res 36: 149–163PubMedCrossRefGoogle Scholar
  5. 5.
    Klein G (1983) Cell 32: 311–315PubMedCrossRefGoogle Scholar
  6. 6.
    Sukamar S, Notario V, Martin-Zanca D, Barbacid M (1983) Nature 306: 658–661CrossRefGoogle Scholar
  7. 7.
    Tabin JG et al. (1982) Nature 300: 143–149PubMedCrossRefGoogle Scholar
  8. 8.
    Collins ST, Ruscetti SW, Gallagher RE, Gallo RC (1978) Proc Natl Acad Sei USA 75: 2458–2461CrossRefGoogle Scholar
  9. 9.
    Rovera G, O’Brien TG, Diamond L (1979) Science 204: 868–870PubMedCrossRefGoogle Scholar
  10. 10.
    Fisher PB et al. (1982) Cancer Res 42: 2829–2835PubMedGoogle Scholar
  11. 11.
    Hanania N, Shaool D, Poncy C, Tapiero H, Harel J (1977) Cell Biol Int Rep 1: 309–315PubMedCrossRefGoogle Scholar
  12. 12.
    Thomas P (1980) Proc Natl Acad Sei USA 76: 5201–5205CrossRefGoogle Scholar
  13. 13.
    Maniatis T, Kee SG, Efstradiatis A, Kafatos FC (1975) Proc Natl Acad Sei USA 1154–1158Google Scholar
  14. 14.
    Kelly K, Cochran BH, Leder P (1983) Cell 35: 603–610PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • J. Harel
  • N. Hanania
  • D. Shaool
  • D. Zeliszewski
  • M. Castagna

There are no affiliations available

Personalised recommendations