Antibodies to Human T-Cell Leukemia Virus-Membrane Antigens in Macaques with Malignant Lymphoma

  • P. J. Kanki
  • T. Homma
  • T. H. Lee
  • N. W. KingJr.
  • R. D. Hunt
  • M. Essex
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 29)


Gallo and co-workers first described human T-cell leukemia virus (HTLV), a type C retrovirus isolated from an aggressive case of cutaneous T-cell lymphoma [27, 28]. Cases of adult T-cell leukemia/lymphoma (ATLL), a unique mature T-cell malignancy, have also yielded numerous other isolates of HTLV [23, 7, 17, 35, 10, 29]. ATLL is seen at increased levels in southwestern Japan and the Caribbean, where seroepidemiologic studies have linked this tumor with HTLV type I. In such endemic regions, natural antibodies can be demonstrated in 4%–37% of the healthy adults whereas more than 90% of patients with ATLL have antibodies to HTLV (11, 31, 1, 32, 5, 20]. The prevalence of HTLV antibodies in healthy individuals is less than 1% in nonendemic areas [12, 6, 5, 20, 3, 4].


Malignant Lymphoma Kalyanaraman Versus 
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  1. 1.
    Blattner WA, Blayney DW, Robert-Guroff M, Sarngadharan MG, Sarin PS, Jaffe ES, Gallo RC (1983) Epidemiology of human T-cell leukemia/lymphoma virus. J Infect Dis 148: 406–416CrossRefGoogle Scholar
  2. 2.
    Daniel MD, King NW, Letvin NL, Hunt RD, Sehgal PK, Desrosiers RC (1984) A new type D retrovirus isolated from macaques with an immunodeficiency Syndrome. Science 223: 602–605PubMedCrossRefGoogle Scholar
  3. 3.
    Essex M, McLane MF, Lee TH, Falk L, Howe CWS, Mullins JI, Cabradilla C, Francis DP (1983) Antibodies to cell membrane antigens associated with human T-cell leukemia virus in patients with AIDS. Science 220: 859–862PubMedCrossRefGoogle Scholar
  4. 4.
    Essex M, McLane MF, Lee TH, Tachibana N, Mullins JI, Kreiss J, Kasper CK, Poon M-C, Landay A, Stein SF, Francis DP, Cabradilla C, Lawrence DN, Evatt BL (1983) Antibodies to human T-cell leukemia virus membrane antigens ( HTLV-MA) in hemophiliacs. Science 221: 1061–1064Google Scholar
  5. 5.
    Essex M, McLane MF, Tachibana N, Francis DP, Lee TH (1984) Seroepidemiology of human T-cell leukemia virus in relation to immunosuppression and the acquired immunodeficiency Syndrome. In: Gallo RC, Essex M, Gross L (eds) Human T-cell leukemia viruses. Cold Spring Harbor Laboratory, Cold Spring Harbor, pp 355–362Google Scholar
  6. 6.
    Gallo RC et al. (1982) Association of the human type C retrovirus with a subset of adult T-cell cancers. Cancer Res 43: 3892–3899Google Scholar
  7. 7.
    Gallo RC, Mann D, Broder S, Ruscetti FW, Maeda M, Kalyanaraman VS, Robert-Guroff M, Reitz MS (1982) Human T-cell leukemialymphoma virus ( HTLV) is in T- but not B-lymphocytes from a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sei USA 79: 5680–5683Google Scholar
  8. 8.
    Hayami M, Ishikawa K, Komuro A, Kawamoto Y, Nozawa K, Yamamoto K, Ishida T, Hinuma Y (1983) ATLV antibody in cynomologus monkeys in the wild. Lancet 2: 620PubMedCrossRefGoogle Scholar
  9. 9.
    Hayami M, Komuro A, Nozawa K, Shotake T, Ishikawa K, Yamamoto K, Ishida T, Honjo S, Hinuma Y (1984) Prevalence of antibody to adult T-cell leukemia virus associated antigens ( ATLA) in Japanese monkeys and other non-human primates. Int J Cancer 33: 179–183Google Scholar
  10. 10.
    Haynes BF, Miller SE, Palker TJ, Moore JO, Dunn PH, Bolognesi DP, Metzgar RS (1983) Identification of human T-cell leukemia virus in a Japanese patient with adult T-cell leukemia and cutaneous lymphomatous vasculitis. Proc Natl Acad Sei USA 80: 2054–2058CrossRefGoogle Scholar
  11. 11.
    Hinuma Y, Nagata K, Hanaoka M, Nakai M, Matsumoto T, Kinoshita K-I, Shirakawa S, Miyoshi I (1981) Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera. Proc Natl Acad Sei USA 78: 6476–6480CrossRefGoogle Scholar
  12. 12.
    Hinuma Y, Komoda H, Chosa T, Kondo T, Kohakura M, Takenaka T, Kikuchi M, Ichimaru M, Yunoki K, Sato I, Matsuo R, Takinuchi Y, Uchinao H, Hanaoka M (1982) Antibodies to adult T-cell leukemkia-virusassociated antigen (ATLA) in sera from patients with ATL and controls in Japan: a nation-wide seroepidemiologic study (1982) Int J Cancer 29: 631–635Google Scholar
  13. 13.
    Homma T, Kanki PJ, King NW, Hunt RD, O’Connell MJ, Letvin NL, Daniel MD, Desrosiers RC, Yang CS, Essex M (1984) Lymphoma in Macaques: association with virus of human T-lymphotrophic family. Science 225: 716–718PubMedCrossRefGoogle Scholar
  14. 14.
    Hunsmann G, Schneider J, Schmitt J, Yamamoto N (1983) Detection of serum antibodies to adult T-cell leukemia virus in non-human primates and in people from Africa. Int J Cancer 32: 329–332PubMedCrossRefGoogle Scholar
  15. 15.
    Hunt RD, Blake BJ, Chalifoux LV, Sehgal PK, King NW, Letvin NL (1983) Transmission of naturally occurring lymphoma in macaque monkeys. Proc Natl Acad Sei USA 80: 5085–5089CrossRefGoogle Scholar
  16. 16.
    Ishida T, Yamamoto K, Kaneko R, Tokita E, Hinuma Y (1983) Seroepidemiological study of antibodies to adult T-cell leukemia virusassociated antigen (ATLA) in free-ranging Japanese monkeys (Macaca fuscatä). Microbiol Immunol 27 (3): 297–301PubMedGoogle Scholar
  17. 17.
    Kalyanaraman VS, Sarngadharan MG, Robert-Guroff M, Miyoshi I, Blayney D, Golde D, Gallo RC (1982) A new sub-type of human T-cell leukemia virus ( HTLV-II) associated with a T-cell variant of hairy cell leukemia. Science 218: 571–573Google Scholar
  18. 18.
    King NW, Hunt RD, Letvin NL (1983) Histopathologic changes in macaque monkeys with an acquired immune deficiency Syndrome ( AIDS ). Am J Pathol 113: 382–388Google Scholar
  19. 19.
    Lapin B (1973) The epidemiologic and genetic aspects of leukemia among hamadrayas baboons of the Sukhumi monkey colony. In: Dutcher RM, Chieco-Bianchi L (eds) Unifying concepts of leukemia. Bibl Haematologica 39: 263–268, Karger, BaselGoogle Scholar
  20. 20.
    Lee TH, Coligan JE, Homma T, McLane MF, Tachibana N, Essex M (1984) Human T-cell leukemia virus-associated membrane antigens: identity of the major antigens recognized after virus infection. Proc Natl Acad Sei USA 81: 3856–3858CrossRefGoogle Scholar
  21. 21.
    Lee TH, Coligan JE, McLane MF, Sodroski JG, Popovic M, Wong-Staal F, Gallo RC, Haseltine W, Essex M (1984) Serological cross-reactivity between envelope gene produets of Type I and Type II human T-cell leukemia virus. Proc Natl Acad Sei USA (in press)Google Scholar
  22. 22.
    Manning JRS, Griesemer RA (1974) Spontaneous lymphoma of the non-human primate. Lab Anim Sei 24: 204–210Google Scholar
  23. 23.
    Miyoshi I, Kubonishi I, Yoshimoto S, Akagi T, Ohtsuki Y, Shiraishi Y, Nagata K, Hinuma Y (1981) Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukaemia T-cells. Nature 294: 770–771PubMedCrossRefGoogle Scholar
  24. 24.
    Miyoshi I, Yoshimoto S, Fujishita M, Taguchi H, Kubonishi I, Niiya K, Minezawa M (1982) Natural adult T-cell leukaemia virus infection in Japanese monkeys. Lancet 2: 658PubMedCrossRefGoogle Scholar
  25. 25.
    Miyoshi I, Fujishita M, Taguchi H, Matsubayashi K, Miwa K, Tanioka Y (1983) Natural infection in non-human primates with adult T-cell leukemia virus or a closely related agent. Int J Cancer 32: 333–336PubMedCrossRefGoogle Scholar
  26. 26.
    O’Gara RW, Adamson RH (1972) Spontaneous and induced neoplasms in non-human Primates. In: Fiennes RNTW (ed) Pathology of simian Primates. Karger, Basel, pp 190–238Google Scholar
  27. 27.
    Poiesz BJ, Ruscetti FW, Gazdar AF, Bunn PA, Minna JD, Gallo RC (1980) Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sei USA 77: 7415–7419CrossRefGoogle Scholar
  28. 28.
    Poiesz BJ, Ruscetti FW, Reitz MW, Kalyanaraman VS, Gallo RC (1981) Isolation of a new type C retrovirus ( HTLV) in primary uncultured cells of a patient with Sezary T-cell leukemia. Nature 294: 268–271Google Scholar
  29. 29.
    Popovic M, Sarin PS, Robert-Guroff M, Kalyanaran VS, Mann D, Minowada J, Gallo RC (1983) Isolation and transmission of human retrovirus (human T-cell leukemia virus). Science 219: 856–859PubMedCrossRefGoogle Scholar
  30. 30.
    Reitz MS, Kalyanaraman VS, Robert-Guroff M, Popovic M, Sarngadharan MG, Sarin PS, Gallo RC (1983) Human T-cell leukemia/ lymphoma virus: the retrovirus of adult T-cell leukemia/lymphoma. J Infect Dis 147: 339–403CrossRefGoogle Scholar
  31. 31.
    Robert-Guroff M, Nakao Y, Notake K, Ito Y, Sliski A, Gallo RC (1982) Natural antibodies to the human retrovirus, HTLV, in a Cluster of Japanese patients with adult T-cell leukemia. Science 215: 975–978Google Scholar
  32. 32.
    Schupbach J, Kalyanaraman VS, Sarngadharan MG, Blattner WA, Gallo RC (1983) Antibodies against three purified proteins of the human type-C retrovirus, human T-cell leukemia-lymphoma virus, in adult T-cell leukemia-lymphoma patients and healthy blacks from the Caribbean. Cancer Res 43: 886–891PubMedGoogle Scholar
  33. 33.
    Stowell RC, Smith EK, Espana C, Nelson VG (1971) Outbreak of malignant lymphoma in rhesus monkeys. Lab Invest 25: 476–479PubMedGoogle Scholar
  34. 34.
    Yamamoto N, Hinuma Y, zur Hausen H, Schneider J, Hunsmann G (1983) African green monkeys are infected with adult T-cell leukemia virus or a closely related agent. Lancet 1: 240–241PubMedCrossRefGoogle Scholar
  35. 35.
    Yoshida M, Miyoshi I, Hinuma Y (1982) Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implications in the disease. Proc Natl Acad Sei USA 79: 2031–2035CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • P. J. Kanki
    • 1
    • 2
  • T. Homma
    • 1
  • T. H. Lee
    • 1
  • N. W. KingJr.
    • 2
  • R. D. Hunt
    • 2
  • M. Essex
    • 1
  1. 1.Department of Cancer BiologyHarvard School of Public HealthBostonUSA
  2. 2.New England Regional Primate Research CenterHarvard Medical SchoolSouthboroughUSA

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