Tumors Induced in Hairless Mice by DNA from Human Malignant Cells

  • F. L. Kisseljov
  • L. Z. Topol
  • A. G. Tatosyan
  • N. G. Nalbandyan
  • E. S. Revasova
  • M. Grofova
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 29)

Abstract

The development of a transfection technique which is based on the transfer of foreign genetic material into permissive cells allows one to isolate and identify the transformed genes in tumors of different etiology [1]. The results which have been obtained in the last few years lead to the conclusion that primary effects in human tumors during their progression are connected with the activation of different genetic elements, among which oncogenes may play an important role [2]. The main aim of this work is the elaboration of an experimental model for the analysis of human tumors and human genome DNA fragments which participate in the process of malignant cell transformation.

Keywords

Leukemia Sarcoma Osteosarcoma Fibrosarcoma Sinovial 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • F. L. Kisseljov
    • 1
  • L. Z. Topol
    • 1
  • A. G. Tatosyan
    • 1
  • N. G. Nalbandyan
    • 1
  • E. S. Revasova
    • 1
  • M. Grofova
    • 2
  1. 1.Cancer Research CenterMoscowUSSR
  2. 2.Cancer Research InstituteBratislavaSlovakia

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