Tumors Induced in Hairless Mice by DNA from Human Malignant Cells
The development of a transfection technique which is based on the transfer of foreign genetic material into permissive cells allows one to isolate and identify the transformed genes in tumors of different etiology . The results which have been obtained in the last few years lead to the conclusion that primary effects in human tumors during their progression are connected with the activation of different genetic elements, among which oncogenes may play an important role . The main aim of this work is the elaboration of an experimental model for the analysis of human tumors and human genome DNA fragments which participate in the process of malignant cell transformation.
KeywordsMalignant Glioma Bladder Carcinoma Hairless Mouse Malignant Glioma Cell Line Malignant Cell Transformation
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