The biologic activity of tumor DNA, detected by transfection of NIH 3T3 mouse cells, has led to the identification of transforming genes which are activated in a variety of human, rodent, and avian neoplasms (see [5] for recent review). The transforming genes of some neoplasms are cellular homologs of the ras genes of Harvey and Kirsten sarcoma viruses. Other neoplasm transforming genes, such as Blym-1, are unrelated to ras or to other retroviral transforming genes. In this article, I will discuss recent work related to functional analysis of the ras and Blym-1 gene produets.


Transferrin Receptor Transforming Gene Guanine Nucleotide Binding Protein Cellular Homolog Transforming Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • G. M. Cooper
    • 1
  1. 1.Dana Farber Cancer Institute and Department of PathologyHarvard Medical SchoolBostonUSA

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