Chromatin Structure of the Human c-myc Oncogene: Definition of Regulatory Regions and Changes in Burkitt’s Lymphomas
Chromosomal translocations of the myc oncogene are a consistent feature of all Burkitt’s lymphomas and are also observed in many murine plasmacytomas. These translocations of myc occur into the immunoglobulin loci and they result in a general increase in myc transcription, but this increase in myc is variable [2, 6, 7, 10, 11, 21, 22]. Since myc may be regulated during the cell cycle (see ), deregulation may mean expression at the inappropriate time, which in turn may result in only a modest overall increase in transcription of myc in Burkitt’s lymphomas. On the other hand, the true (and unidentifled) precursor cell of Burkitt’s lymphomas may have a very low level of myc transcription and we are as yet unable to assess properly the true increase in transcription as a consequence of translocations.
KeywordsChromatin Structure Burkitt Lymphoma Hypersensitive Site Avian Leukosis Virus Heavy Chain Locus
Unable to display preview. Download preview PDF.
- 8.Hayday A, Gillies S, Saito H, Wood C, Wi-. man K, Hayward W, Tonegawa S (1984) Activation of a translocated human c-myc gene by an enhancer in the immunoglobulin heavy chain locus. Nature 307: 334–340Google Scholar