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Chromatin Structure of the Human c-myc Oncogene: Definition of Regulatory Regions and Changes in Burkitt’s Lymphomas

  • U. Siebenlist
  • L. Hennighausen
  • J. Battey
  • P. Leder
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 29)

Abstract

Chromosomal translocations of the myc oncogene are a consistent feature of all Burkitt’s lymphomas and are also observed in many murine plasmacytomas. These translocations of myc occur into the immunoglobulin loci and they result in a general increase in myc transcription, but this increase in myc is variable [2, 6, 7, 10, 11, 21, 22]. Since myc may be regulated during the cell cycle (see [9]), deregulation may mean expression at the inappropriate time, which in turn may result in only a modest overall increase in transcription of myc in Burkitt’s lymphomas. On the other hand, the true (and unidentifled) precursor cell of Burkitt’s lymphomas may have a very low level of myc transcription and we are as yet unable to assess properly the true increase in transcription as a consequence of translocations.

Keywords

Chromatin Structure Burkitt Lymphoma Hypersensitive Site Avian Leukosis Virus Heavy Chain Locus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • U. Siebenlist
    • 1
  • L. Hennighausen
    • 2
  • J. Battey
    • 3
  • P. Leder
    • 2
  1. 1.Laboratory of ImmunoregulationNiaid, NihBethesdaUSA
  2. 2.Department of GeneticsHarvard Medical SchoolBostonUSA
  3. 3.Nci Navy Oncology-Hematology DepartmentNational Naval Medical CenterBethesdaUSA

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