Skip to main content
SpringerLink
Log in

Chromatin Structure of the Human c-myc Oncogene: Definition of Regulatory Regions and Changes in Burkitt’s Lymphomas

  • Conference paper
Modern Trends in Human Leukemia VI New Results in Clinical and Biological Research Including Pediatric Oncology

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 29))

  • 60 Accesses

Abstract

Chromosomal translocations of the myc oncogene are a consistent feature of all Burkitt’s lymphomas and are also observed in many murine plasmacytomas. These translocations of myc occur into the immunoglobulin loci and they result in a general increase in myc transcription, but this increase in myc is variable [2, 6, 7, 10, 11, 21, 22]. Since myc may be regulated during the cell cycle (see [9]), deregulation may mean expression at the inappropriate time, which in turn may result in only a modest overall increase in transcription of myc in Burkitt’s lymphomas. On the other hand, the true (and unidentifled) precursor cell of Burkitt’s lymphomas may have a very low level of myc transcription and we are as yet unable to assess properly the true increase in transcription as a consequence of translocations.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Battey J, Moulding C, Taub R, Murphy W, Stewart T, Potter H, Lenoir G, Leder P (1983) The human c-myc oncogene: structural consequences of translocation into the IgH in Burkitt lymphoma. Cell 34: 779–789

    Article  PubMed  CAS  Google Scholar 

  2. Bernard O, Cory S, Gerondakis S, Webb E, Adams JM (1983) Sequence of the murine and human cellular myc oncogenes and two modes of myc transcription resulting from chromosome translocation in B lymphoid tumors. EMBO J 2: 2375–2383

    PubMed  CAS  Google Scholar 

  3. Dalla-Favera R, Martinotti S, Gallo R, Erikson J, Croce C (1983) Translocation and rearrangements of the c-myc oncogene locus in human and undifferentiated B-cell lymphomas. Science 219: 963–967

    Article  PubMed  CAS  Google Scholar 

  4. Dierks P, van Ooyen A, Cochran M, Dobkin C, Riser J, Weissmann C (1983) Three regions upstream from the CAP site are required for efficient and accurate transcription of the rabbit beta-globin gene in mouse 3T6 cells. Cell 32: 695–706

    Article  PubMed  CAS  Google Scholar 

  5. Emerson BM, Felsenfeld G (1984) Specific factor conferring nuclease hypersensitivity at the 5’ end of the chicken adult beta-globin gene. Proc Natl Acad Sei USA 81: 95–99

    Article  CAS  Google Scholar 

  6. Erikson J, ar-Rushdi A, Drwinga HL, Nowell PC, Croce C (1983) Transcriptional activation of the translocated c-myc oncogene in Burkitt lymphoma. Proc Natl Acad Sei USA 80: 820–824

    Article  CAS  Google Scholar 

  7. Hamlyn PH, Rabbitts TH (1983) Translocation joins c-myc and immunoglobulin gamma-1 genes in Burkitt lymphoma revealing a third exon in the c-myc oncogene. Nature 304: 135–139

    Article  PubMed  CAS  Google Scholar 

  8. Hayday A, Gillies S, Saito H, Wood C, Wi-. man K, Hayward W, Tonegawa S (1984) Activation of a translocated human c-myc gene by an enhancer in the immunoglobulin heavy chain locus. Nature 307: 334–340

    CAS  Google Scholar 

  9. Kelly K, Cochran B, Stiles C, Leder P (1983) Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet derived growth factor. Cell 35: 603–610

    Article  PubMed  CAS  Google Scholar 

  10. Leder P, Battey J, Lenoir G, Moulding C, Murphy W, Potter H, Stewart T, Taub R (1983) Translocations among antibody genes in human cancer. Science 222: 765–771

    Article  PubMed  CAS  Google Scholar 

  11. Maguire RT, Robins TS, Thorgeirsson S, Heilman CA (1983) Expression of cellular myc and mos genes in undifferentiated B cell lymphomas of Burkitt and non-Burkitt types. Proc Natl Acad Sei USA 80: 1947–1950

    Article  CAS  Google Scholar 

  12. Nagata K, Guggenheimer RA, Hurwitz J (1983) Specific binding of a cellular DNA replication protein to the origin of replication of adenovirus DNA. Proc Natl Acad Sei USA 80: 6177–6181

    Article  CAS  Google Scholar 

  13. Nishikura K, ar-Rushdi A, Erikson J, Watt R, Rovera G, Croce CM (1983) Differential expression of the normal and of the translocated human c-myc oncogenes in B cells. Proc Natl Acad Sei USA 80: 4822–4826

    Article  CAS  Google Scholar 

  14. Parslow T, Granner D (1983) Structure of a nuclease-sensitive region inside the immunoglobulin kappa gene: evidence for a role in gene regulation. Nucleic Acids Res 11: 4775–4792

    Article  PubMed  CAS  Google Scholar 

  15. Rabbitts TH, Hamlyn PH, Baer R (1983) Altered nucleotide sequence of a translocated c-myc gene in Burkitt lymphoma. Nature 306: 760–765

    Article  PubMed  CAS  Google Scholar 

  16. Schubach W, Groudine M (1984) Alteration of c-myc chromatin structure by avian leukosis virus integration. Nature 307: 702–708

    Article  PubMed  CAS  Google Scholar 

  17. Siebenlist U, Hennighausen L, Battey J, Leder P (1984) Chromatin structure and protein binding in the putative regulatory region of the c-myc gene in Burkitt lymphoma. Cell 37: 381–391

    Article  PubMed  CAS  Google Scholar 

  18. Stalder J, Larsen A, Engel J, Dolan M, Groudine M, Weintraub H (1980) Tissuespecific DNA cleavages in the globin chromatin domain introduced by DNAase I. Cell 20: 451–460

    Article  PubMed  CAS  Google Scholar 

  19. Stanton LW, Watt R, Marcu KB (1983) Translocation, breakage and truncated transcripts of c-myc oncogene in murine plasmacytomas. Nature 303: 401–406

    Article  PubMed  CAS  Google Scholar 

  20. Taub R, Kirsch I, Morton C, Lenoir G, Swan D, Tronick S, Aaronson S, Leder P (1982) Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells. Proc Natl Acad Sei USA 79: 7837–7841

    Article  CAS  Google Scholar 

  21. Taub R, Moulding C, Battey J, Murphy W, Vasicek T, Lenoir G, Leder P (1984) Activation and somatic mutation of the translocated c-myc gene in Burkitt lymphoma cells. Cell 36: 339–348

    Article  PubMed  CAS  Google Scholar 

  22. Westin EH, Wong-Staal F, Gelman EP, Dalla- Favera R, Papas T, Lautenberger JA, Eva A, Reddy EP, Tronick SR, Aaronson SA, Gallo RC (1982) Expression of cellular homologs of retroviral one genes in human hematopoietic cells. Proc Natl Acad Sei USA 79: 2490–2494

    Article  CAS  Google Scholar 

  23. Wu C (1980) The 5’ ends of Drosophila heat shock genes in chromatin are hypersensitive to DNAase I. Nature 286: 854–860

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Immunoregulation, Niaid, Nih, Bethesda, MD, USA

    U. Siebenlist

  2. Department of Genetics, Harvard Medical School, Boston, MA, USA

    L. Hennighausen & P. Leder

  3. Nci Navy Oncology-Hematology Department, National Naval Medical Center, Bethesda, MD, USA

    J. Battey

Authors
  1. U. Siebenlist
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. L. Hennighausen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. Battey
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. P. Leder
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Medizinische Klinik, Abteilung für klinische Chemie, Universitäts-Krankenhaus Eppendorf, Martinistraße 52, 2000, Hamburg 20, Germany

    Rolf Neth

  2. Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD, 20205, USA

    Robert C. Gallo

  3. Leukaemia Research Fund Centre, Chester Beatty Laboratories, Institute of Cancer Research, Fulham Road, London, SW3 6JB, UK

    Melvyn F. Greaves

  4. Abteilung für Hämatologie und Onkologie, Universitäts-Kinderklinik, Martinistraße 52, 2000, Hamburg 20, Germany

    Gritta Janka

Rights and permissions

Reprints and permissions

Copyright information

© 1985 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Siebenlist, U., Hennighausen, L., Battey, J., Leder, P. (1985). Chromatin Structure of the Human c-myc Oncogene: Definition of Regulatory Regions and Changes in Burkitt’s Lymphomas. In: Neth, R., Gallo, R.C., Greaves, M.F., Janka, G. (eds) Modern Trends in Human Leukemia VI New Results in Clinical and Biological Research Including Pediatric Oncology. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 29. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70385-0_53

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-70385-0_53

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-15329-0

  • Online ISBN: 978-3-642-70385-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation