Discrimination of Leukemias, Lymphomas, and Non-Neoplastic Controls by Retroviral Serum Markers
Diagnostic and prognostic markers are urgently needed for early diagnosis and therapy of malignant neoplasias. One Solution of this problem is the search for etiologic factors in the hope that they might indicate the presence or degree of progression of the disease. One possible factor are the retroviruses which are known to cause certain malignancies in several animal species . These malignancies include leukemias, lymphomas, and sarcomas. Footprints of retroviruses have also been repeatedly described in man, and retroviral isolates have been grown from human neoplastic and non-neoplastic cells. These viral isolates include not only the human T lymphotropic viruses (HTLV-I-III), but also viruses that are very similar to the primate retroviruses simian sarcoma virus (SiSV) and baboon endogenous virus (BaEV) [2, 3, 6].
KeywordsAcute Leukemia Malignant Lymphoma Blast Crisis Stepwise Discriminant Analysis Gp70 Envelope
Unable to display preview. Download preview PDF.
- 1.Gross L (1983) Oncogenic viruses, 3rd edn. Pergamon, OxfordGoogle Scholar
- 2.Gallo RC, Wong-Staal F, Ruscetti F (1982) Viruses and adult leukemia-lymphoma ofman and relevant animal models. In: Bloomfield CD (ed) Adult leukemias, pp 1–41Google Scholar
- 3.Hehlmann R, Schetters H, Kreeb G, Erfle V, Schmidt J, Luz A (1983 a) RNA-tumorviruses, oncogenes, and their possible role in human carcinogenesis. Klin Wochenschr 61: 1217–1231Google Scholar
- 5.Hehlmann R, Erfle V, Schetters H, Luz A, Rohmer H, Schreiber MA, Essers U, Pralle H, Weber W (1984) Antigens and circulating immune complexes related to the primate retroviral-glycoprotein SiSV gp70: Indicators of early mortality in human acute leukemias and chronic myelogenous leukemia in blast crisis. Cancer 54: 2927–2935Google Scholar
- 6.Popovic M, Sarngadharan MG, Read E, Gallo RC (1984) Detection, isolation, and continuous production of cytopathic retroviruses ( HTLV-III) from patients with AIDS and pre- AIDS. Science 224: 497–500Google Scholar
- 10.O’Connell C, O’Brien S, Nash WG, Cohen M (1984) ERV3, a füll length human endogenous provirus: chromosomal localization and evolutionary relationships. Virology 138: 225–235 214Google Scholar