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Myelolactoferrin Index (MLF) and Myelopoiesis During Bacterial Infections and Malignant Diseases

  • Conference paper
Modern Trends in Human Leukemia VI New Results in Clinical and Biological Research Including Pediatric Oncology

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 29))

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Abstract

The myelolactoferrin index (MLF) is significantly lowered in patients with bacterial infections and with malignant diseases. In both cases it can be assumed that the alteration of the granulopoietic storage pool is followed by a decrease in lactoferrin. Therefore, it seems advisable to study (a) to what extent the immunocytochemical quantitative evaluation of lactoferrin content of mature neutrophil granulocytes can be used to recognize any toxic damage caused to bone marrow cells by long-term therapies or environmental toxins and (b) whether this method is more sensitive than the conventional counting of granulocytes and thrombocytes.

Universitätskliniken D-2000 Hamburg 20, Martinistrasse 52, FRG

Supported by the Deutsche Forschungsgemeinschaft and the Deutsche Krebshilfe

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References

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Authors
  1. R. Neth
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  2. J. Nowrath
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  3. M. Thomsen
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  4. C. Wiggers
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  5. M. Gabrecht
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  6. W. Rehpenning
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  7. K. Winkler
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  8. U. Krause
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  9. H. Soltau
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  10. H. Kraemer-Hansen
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Editor information

Editors and Affiliations

  1. Medizinische Klinik, Abteilung für klinische Chemie, Universitäts-Krankenhaus Eppendorf, Martinistraße 52, 2000, Hamburg 20, Germany

    Rolf Neth

  2. Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD, 20205, USA

    Robert C. Gallo

  3. Leukaemia Research Fund Centre, Chester Beatty Laboratories, Institute of Cancer Research, Fulham Road, London, SW3 6JB, UK

    Melvyn F. Greaves

  4. Abteilung für Hämatologie und Onkologie, Universitäts-Kinderklinik, Martinistraße 52, 2000, Hamburg 20, Germany

    Gritta Janka

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© 1985 Springer-Verlag Berlin Heidelberg

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Neth, R. et al. (1985). Myelolactoferrin Index (MLF) and Myelopoiesis During Bacterial Infections and Malignant Diseases. In: Neth, R., Gallo, R.C., Greaves, M.F., Janka, G. (eds) Modern Trends in Human Leukemia VI New Results in Clinical and Biological Research Including Pediatric Oncology. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 29. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70385-0_41

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  • DOI: https://doi.org/10.1007/978-3-642-70385-0_41

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-15329-0

  • Online ISBN: 978-3-642-70385-0

  • eBook Packages: Springer Book Archive

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