Abstract
Recent reports by Baccarani and Tura [2], Moloney and Rosenthal [9], and Housset et al. [6] prompted us to treat 12 acute myeloid leukemia (AML) and 4 myelodysplastic Syndrome (MDS) patients with low dose cytosine arabinoside (Ara-C). In all patients, conventional chemotherapy was contraindicated because of previous inefficacy, advanced age, or heavy comorbidity. Ara-C was given in a dose of 10 mg/m2 s. c. every 12 h for 14–28 days. All patients received one or two courses. If bone marrow revealed more than 5% blasts 1 week after the end of therapy, another course was started. Patients who obtained a complete or partial remission received maintenance chemotherapy with low dose Ara-C (10 mg/m2 s. c. every 12 h) for 8 days every 3 or 4 weeks.
Keywords
- Acute Myeloid Leukemia
- Polycythemia Vera
- Cytosine Arabinoside
- Bone Marrow Hypoplasia
- Arabinosyl Cytosine
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Department of Oncology and Hematology, University of Hamburg, Martinistr. 52, D-2000 Hamburg 20, FRG
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Weh, H.J., Zschaber, R., von Paleske, A., Hossfeld, D.K. (1985). Treatment of Acute Myeloid Leukemia and Myelodysplastic Syndrome by Low Dose Cytosine Arabinoside. In: Neth, R., Gallo, R.C., Greaves, M.F., Janka, G. (eds) Modern Trends in Human Leukemia VI New Results in Clinical and Biological Research Including Pediatric Oncology. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 29. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70385-0_14
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DOI: https://doi.org/10.1007/978-3-642-70385-0_14
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