Treatment of Acute Myeloid Leukemia and Myelodysplastic Syndrome by Low Dose Cytosine Arabinoside
Recent reports by Baccarani and Tura , Moloney and Rosenthal , and Housset et al.  prompted us to treat 12 acute myeloid leukemia (AML) and 4 myelodysplastic Syndrome (MDS) patients with low dose cytosine arabinoside (Ara-C). In all patients, conventional chemotherapy was contraindicated because of previous inefficacy, advanced age, or heavy comorbidity. Ara-C was given in a dose of 10 mg/m2 s. c. every 12 h for 14–28 days. All patients received one or two courses. If bone marrow revealed more than 5% blasts 1 week after the end of therapy, another course was started. Patients who obtained a complete or partial remission received maintenance chemotherapy with low dose Ara-C (10 mg/m2 s. c. every 12 h) for 8 days every 3 or 4 weeks.
KeywordsToxicity Leukemia Neutropenia Cytosine Cytarabine
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