Influence of Colchicine and Cytochalasin B on Pinocytosis, Phagocytosis, and Antibody-Dependent Cell-Mediated Cytotoxicity

  • A. Piasek
  • P. Oblakowski
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 29)

Abstract

The cytoskeleton is an organelle of eukaryotic cells engaged in Organization and external and internal cell movements, e. g., endocytosis. Our previous experiments proved that colchicine (an antitubular drug) and cytochalasin B (cyt B, an antimicrofilament agent) have significant influence on the development of the process [8, 9]. Reports on the inhibiting effect of the development of antibody-dependent cellmediated cytotoxicity (ADCC) are inconsistent. The aim of the present work was to examine the influence of colchicine and cyt B on the development and mutual dependence of pinocytosis, phagocytosis, and cytotoxic effect.

Keywords

Hydrogen Peroxide Leukemia Superoxide Bacillus Dition 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • A. Piasek
    • 1
  • P. Oblakowski
    • 2
  1. 1.Department of Histology and EmbryologyInstitute of Biostructure, Medical SchoolWarsawPoland
  2. 2.Department of MedicineInstitute of HaematologyWarsawPoland

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