Abstract
The cytoskeleton is an organelle of eukaryotic cells engaged in Organization and external and internal cell movements, e. g., endocytosis. Our previous experiments proved that colchicine (an antitubular drug) and cytochalasin B (cyt B, an antimicrofilament agent) have significant influence on the development of the process [8, 9]. Reports on the inhibiting effect of the development of antibody-dependent cellmediated cytotoxicity (ADCC) are inconsistent. The aim of the present work was to examine the influence of colchicine and cyt B on the development and mutual dependence of pinocytosis, phagocytosis, and cytotoxic effect.
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References
Adams DO, Kao KJ, Färb R, Pizzo SU (1980) Effector mechanisms of cytolytically activated macrophages. II. Secretion of a cytolytic factor by activated macrophages and it’s relationship to secreted neutral proteases. J Immunol 124: 239–300
Currie GAW (1978) Activated macrophages kill tumor cells by releasing arginase. Nature 273: 758–759
Fleer A, Van Schaik MLJ, Von Der Borne AEGK, Engelfriet CP (1978) Destruction of sensitized erythrocytes by human monocytes in vitro: effects of cytochalasin B, hydrocortisone and colchicine. Scand J Immunol 8: 515–524
Graham RC, Karnowsky MJ (1966) The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique. J Histochem Cytochem 14: 669–684
Hibbs JB Jr (1974) Heterocytolysis by macrophages activated by Bacillus Calmette- Guerin: lysosomal exocytosis into the tumor cells. Science 184: 468–471
Johnston RBJ, Godzik CA, Cohn ZA (1978) Increased Superoxide anion production by immunologically activated and chemically elicited macrophages. J Exp Med 148: 115–127
Nathan C, Cohn Z (1980) Role of oxygendependent mechanisms in antibody-induced lysis of tumor cells by activated macrophages. J Exp Med 152: 198–208
Piasek A, Thyberg J (1979) Effects of colchicine on endocytosis and cellular inactivation of horseradish peroxidase in cultured chondrocytes. J Cell Biol 81: 426–437
Piasek A, Thyberg J (1980) Effects of colchicine on endocytosis of horseradish peroxidase by rat peritoneal macrophages. J Cell Sei 45: 59–71
Southwick FS, Stossel TP (1983) Contractile proteins in leukocyte function. Sem Hematol 20: 305–320
Walker WS, Demus A (1975) Antibody-dependent cytolysis of chicken erythrocytes by an in vitro established line of mouse peritoneal macrophages. J Immunol 114: 765–769
Walker WS (1977) Mediation of macrophage cytolytic and phagocytic activities by antibodies of different classes and class-specific Fe receptors. J Immunol 119: 367–373
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© 1985 Springer-Verlag Berlin Heidelberg
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Piasek, A., Oblakowski, P. (1985). Influence of Colchicine and Cytochalasin B on Pinocytosis, Phagocytosis, and Antibody-Dependent Cell-Mediated Cytotoxicity. In: Neth, R., Gallo, R.C., Greaves, M.F., Janka, G. (eds) Modern Trends in Human Leukemia VI New Results in Clinical and Biological Research Including Pediatric Oncology. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 29. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70385-0_103
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DOI: https://doi.org/10.1007/978-3-642-70385-0_103
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