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Leukocyte Counts and Complement Activation During Arteriovenous and Pump-Driven Hemofiltration

  • J. Böhler
  • P. Kramer
  • G. Schlag
  • H. Redel
  • O. Götze
  • P. Schwartz

Abstract

Significant leukopenia accompanied by complement activation and impairment of pulmonary function [1, 16] after starting a dialysis treatment were first observed by Kaplow and Goffinet in 1968 [13]. These changes are most striking when cuprophane membranes are used for dialysis [12]. Craddock et al. have studied these side effects of hemodialysis thoroughly and postulate the following pathogenesis: The complement system is activated during contact of the plasma with the dialyzer membrane [3, 4]. C5a fragment of the complement component C5 induces aggregation of granulocytes in the patient’s venous blood [5, 10, 17]. These aggregates are trapped in the pulmonary microvessels resulting in a transient, profound leukopenia of the peripheral blood [19].

Keywords

Leukocyte Count Complement Activation Cellulose Triacetate Cuprophane Membrane Complement Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • J. Böhler
  • P. Kramer
  • G. Schlag
  • H. Redel
  • O. Götze
  • P. Schwartz

There are no affiliations available

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