Potential Risks of Large-Volume Intravenous Fluid Therapy by Bacteria, Endotoxins, Trace Elements, and Particulate Matter
Continuous arteriovenous hemofiltration (CAVH) has become a well-established alternative to dialysis therapy for acute renal failure (ARF) due to the multiple major advantages related to CAVH as discussed elsewhere in this book. The continued poor patient survival despite better alimentation, cardiovascular stability, and other advantages is an unresolved problem with CAVH. Late unexpected fatal complications despite successful maintenance by CAVH occur frequently at a time when the patient appears to recover from multiple organ failure. This puzzling Observation was shared by all members of an international panel at a symposium on CAVH for ARF at the University of Michigan in March 1984. In search for possible explanations for these late complications this chapter will review potential problems related to large-volume i.v. fluid administration.
KeywordsMultiple Organ Failure Rubber Particle United States Pharmacopeia Poor Patient Survival Substitution Fluid
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