Structural and Functional Studies of Mouse Class II Genes

  • M. Steinmetz


This review summarizes our current knowledge about the organization, structure, expression, and evolution of the class II genes in the major histocompatibility complex (MHC) of the mouse. Class II genes code for highly polymorphic cell surface molecules, called class II antigens or Ia antigens. The mouse class II antigens are the counterparts to the human HLA-DP, DQ, and DR antigens (previously called SB, DC/DS/MB, and DR, respectively) which are encoded in the D region of the HLA complex. Class II molecules play an important role in the generation of immune responses because they are involved in the recognition of foreign antigens by regulatory T cells (for recent reviews see [28, 65]).


Major Histocompatibility Complex Congenital Adrenal Hyperplasia Major Histocompatibility Complex Gene Gene Conversion Event Human Class 
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