Advertisement

Class II HLA Antigens in Benign and Malignant Lesions of Melanocytic Origin

  • D. J. Ruiter
  • S. G. van Duinen
  • M. Tsujisaki
  • S. Ferrone

Abstract

Following the unexpected detection of immunologically functional class II HLA antigens on melanoma cells in long–term culture [1, 2], several investigators have analyzed the expression of these antigens by surgically removed benign and malignant lesions of melanocytic origin [3–6]. These studies have been facilitated by the availability of monoclonal antibodies (MoAbs) which have contributed to the application of immunohistochemical techniques.

Keywords

Melanoma Cell Primary Cutaneous Melanoma Melanocytic Lesion Melanoma Lesion Dysplastic Nevus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Winchester RJ, Wang CY, Gibofsky A, Kunkel HG, Lloyd KO, Old LJ (1978) Expression of class II HLA on cultured human malignant melanoma cell lines. Proc Natl Acad Sci USA 75:6235–6239PubMedCrossRefGoogle Scholar
  2. 2.
    Wilson BS, Indiveri F, Pellegrino MA, Ferrone S (1979) DR (Ia–like) antigens on human melanoma cells. Serological detection and immunochemical characterisation. J Exp Med 148:658–668CrossRefGoogle Scholar
  3. 3.
    Natali PG, Cordiali Fei P, Cavaliere R, Di Filippo F, Quaranta V, Pellegrino MG, Ferrone S (1981) Class II HLA on freshly explanted human malignant melanoma. Detection with MoAb and correlation with clinical parameters. Clin Immunol Immuno–pathol 19:250–259CrossRefGoogle Scholar
  4. 4.
    Ruiter DJ, Bhan AK, Harrist TJ, Sober AJ, Mihm MC Jr (1982) Major histocompatibility antigens and mononuclear inflammatory infiltrate in benign nevomelanocytic proliferations and malignant melanoma. J Immunol 129:2808–2815PubMedGoogle Scholar
  5. 5.
    Thompson JJ, Herlyn MF, Elder DE, Clark WH, Steplewski Z, Koprowski H (1982) Use of MoAb in detection of melanoma-associated antigens in intact human tumors. Am J Pathol 107:357–361PubMedGoogle Scholar
  6. 6.
    Thompson JJ, Herlyn MF, Elder DE, Clark WH, Steplewski Z, Koprowski H (1982) Expression of DR antigens in freshly frozen human tumors. Hybridoma 1:161–168PubMedCrossRefGoogle Scholar
  7. 7.
    Ng AK, Pellegrino MA, Imai K, Ferrone S (1981) HLA-A,B antigens, class II HLA, and tumor associated antigens on prostate carcinoma cell lines: serologic and immunochemical analysis with MoAb. J Immunol 127:443–447PubMedGoogle Scholar
  8. 8.
    Quaranta V, Pellegrino MA, Ferrone S (1981) Serological and immunochemical characterization of the specificity of four MoAb to distinct determinants expressed on subpopulations of human class II HLA. J Immunol 125:548–665Google Scholar
  9. 9.
    Reinherz EL, Kung PC, Pesando JM, Ritz J, Goldstein G, Schlossman SF (1979) Ia determinants on human T cell subsets defined by monoclonal antibodies: activation stimuli required for expression. J Exp Med 150:1472–1480PubMedCrossRefGoogle Scholar
  10. 10.
    Lloyd KO, Ng J, Dippold WG (1981) Analysis of the biosynthesis of HLA–DR glycoproteins in human malignant melanoma cell lines. J Immunol 126:2408–2417PubMedGoogle Scholar
  11. 11.
    Koprowski H, Steplewski Z, Herlyn D, Herlyn M (1978) Study of antibodies against human melanoma produced by somatic cell hybrids. Proc Natl Acad Sci USA 75:3405–3410PubMedCrossRefGoogle Scholar
  12. 12.
    Acolla RS, Gross N, Carrel S, Corte G (1981) Distinct forms of both α and β subunits are present in the human Ia molecular pool. Proc Natl Acad Sci USA 78:4549–4551CrossRefGoogle Scholar
  13. 13.
    Bröcker EB, Suter L, Sorg C (1984) HLA–DR antigen expression in primary melanomas of the skin. J Invest Dermatol 82:244–247PubMedCrossRefGoogle Scholar
  14. 14.
    Ghosh AK, Gatter KC, Mason DY (1984) Immunocytochemical characterization of monoclonal anti–HLA–DR antibodies. Dis Markers 2:223–233Google Scholar
  15. 15.
    Epenetos AA, Bobrow LG, Adams TE, Collins CM, Isaacson PG, Bodmer WF (1985) A monoclonal antibody that detects HLA–D region antigen in routinely fixed, wax embedded sections of normal and neoplastic lymphoid tissues. J Clin Pathol 38:12–17PubMedCrossRefGoogle Scholar
  16. 16.
    Adams TE, Bodmer JG, Bodmer WF (1983) Production and characterization of monoclonal antibodies recognizing the α–chain subunits of human Ia alloantigens. Immunology 50:613–614PubMedGoogle Scholar
  17. 17.
    Wilson BS, Herzig A, Lloyd RV (1984) Immunoperoxidase staining for Ia–like antigens in paraffin–embedded tissues from human melanoma and lung carcinoma. Am J Pathol 115:102–116PubMedGoogle Scholar
  18. 18.
    Workshop on monoclonal antibodies to human MHC class II antigens (1984). Dis Markers 2:363–369Google Scholar
  19. 19.
    Crumpton MJ, Bodmer JG, Bodmer WF, Heyes JM, Lindsay J, Rudd CE (1984) Biochemistry of class II antigens: workshop report. In: Albert ED, Baur MP, Mayr WR (eds) Histocompatibility testing 1984. Springer, Berlin Heidelberg New York Tokyo, pp 29–37Google Scholar
  20. 20.
    Quaranta V, Majdic O, Sintl G, Liszka K, Honigsmann H, Knapp W (1984) A human Ia cytoplastic determinant located on multiple forms of invariant chain (γ, γ2, γ3). J Immunol 132:1900–1905PubMedGoogle Scholar
  21. 21.
    Natali PG, Segatto O, Ferrone S, Tosi R, Corte G (1984) Differential tissue distribution and ontogeny of DC–1 and HLA–DR antigens. Immunogenetics 19:109–115PubMedCrossRefGoogle Scholar
  22. 22.
    Polak J, Van Noorden S (1983) Immunocytochemistry. Wright, BristolGoogle Scholar
  23. 23.
    Harrist TJ, Ruiter DJ, Bhan AK, Mihm MC Jr (1983) The distribution of major histocompatibility antigens in normal skin. Br J Dermatol 109:623–633PubMedCrossRefGoogle Scholar
  24. 24.
    Natali PG, Giacomini P, Russo C, Steinbach G, Fenoglio C, Ferrone S (1983) Antigenic profile of human melanoma cells. Analysis with monoclonal antibodies to histocompatibility antigens and to melanoma–associated antigens. J Cutan Pathol 10:225–237PubMedCrossRefGoogle Scholar
  25. 25.
    Poppema S, Bröcker EB, De Ley L, Terbrack D, Visscher T, Ter Haar A, Macher E, Thé HT, Sorg C (1983) In situ analysis of the mononuclear infiltrate in primary malignant melanoma of the skin. Clin Exp Immunol 51:77–82PubMedGoogle Scholar
  26. 26.
    Ruiter DJ, Bergman W, Welvaart K, Scheffer E, Van Vloten WA, Russo C, Ferrone S (1984) Immunohistochemical analysis of malignant melanomas and nevocellular nevi with monoclonal antibodies to distinct monomorphic determinants of HLA antigens. Cancer Res 44:3930–3935PubMedGoogle Scholar
  27. 27.
    Kindt TJ, Mach B, Sogn JA, Robinson MA, Kulaga H, Möller E, Carlsson B, Wallin J, Bach FH (1984) Editorial review: identical or distinct functional roles for products of the HLA–DR, DC, and SB loci. Scand J Immunol 20:471–492PubMedCrossRefGoogle Scholar
  28. 28.
    Houghton AN, Thomson TM, Gross D, Oettgen HF, Old LJ (1984) Surface antigens of melanoma and melanocytes. Specificity of induction of Ia antigens by human γ–in–terferon. J Exp Med 160:255–269PubMedCrossRefGoogle Scholar
  29. 29.
    Pober JS, Gimbrone MA Jr (1982) Expression of Ia–like antigens by human vascular endothelial cells is inducible in vitro: demonstration by monoclonal antibody binding and immunoprecipitation. Proc Natl Acad Sci USA 79:6641–6645PubMedCrossRefGoogle Scholar
  30. 30.
    Pober JS, Gimbrone MA Jr, Cotran RS, Reiss CS, Burakoff SJ, Fiers W, Ault KA (1983) Ia expression by vascular endothelium is inducible by activated T cells and by human γ–interferon. J Exp Med 157:1339–1346PubMedCrossRefGoogle Scholar
  31. 31.
    Collins T, Korman AJ, Wake CT, Boss JM, Kappes DJ, Fiers W, Ault KA, Gimbrone MA Jr, Strominger JL, Pober JS (1984) Immune interferon activates multiple class II major histocompatibility complex genes and the associated invariant chain gene in human endothelial cells and dermal fibroblasts. Proc Natl Acad Sci USA 81:4917–4921PubMedCrossRefGoogle Scholar
  32. 32.
    Basham TY, Nickoloff BJ, Merigan TC, Morhenn VB (1984) Recombinant gamma interferon induces HLA–DR expression on cultured human keratinocytes. J Invest Dermatol 83:88–93PubMedCrossRefGoogle Scholar
  33. 33.
    Schwartz R, Momburg G, Moldenhauer G, Dörken B, Schirrmacher V (1985) Induction of HLA class–II antigen expression on human carcinoma cell lines by IFN–gamma. Int J Cancer 35:245–252PubMedCrossRefGoogle Scholar
  34. 34.
    Koefler HP, Ranyard J, Yelton L, Billing R, Bohman R (1984) γ–Interferon induces expression of the HLA–D antigens on normal and leukemic human myeloid cells. Proc Natl Acad Sci USA 81:4080–4084; Cancer 35:245–252CrossRefGoogle Scholar
  35. 35.
    Kelley VE, Fiers W, Strom TB (1984) Cloned human interferon–γ, but not interferon –β or –α, induces expression of HLA–DR determinants by fetal monocytes and myeloid leukaemic cell lines. J Immunol 132:240–245PubMedGoogle Scholar
  36. 36.
    Holzmann B, Johnson JP, Kandewitz P, Braun-Falco O, Riethmüller G (1984) Differential expression of antigens 15.75 and p3.58 on primary melanoma and benign nevi. Behring Inst Mitt 74:24–26PubMedGoogle Scholar
  37. 37.
    Murphy GF, Bhan AK, Sato S, Harrist TJ, Mihm MC Jr (1981) Characterisation of Iangerhans cells by the use of monoclonal antibodies. Iab Invest 45:465–472Google Scholar
  38. 38.
    Bergman W, Willemze R, de Graaff-Reitsma C, Ruiter DJ (1985) Analysis of major histocompatibility antigens and the mononuclear cell infiltrate in halo nevi. J Invest Dermatol 85:25–29PubMedCrossRefGoogle Scholar
  39. 39.
    Ruiter DJ, Bergman W, Steylen PN, Scheffer E (1984) Histopathological aspects of dysplastic nevi. In: Ruiter DS, Welvaart K, Ferrone S (eds) Cutaneous melanoma and precursor lesions. Nijhoff, The Hague, The Netherlands, pp 239–248CrossRefGoogle Scholar
  40. 40.
    Van Duinen SG, Ruiter DJ, Bröcker EB, Sorg C, Welvaart K, Ferrone S (1984) Association of low level of HLA–A,B,C antigens on high level of Ia antigens in metastatic melanoma with a high grade of malignancy. J Invest Dermatol 82:558Google Scholar
  41. 41.
    Van Duinen SG, Ruiter DJ, Ferrone S (submitted) Expression of class II MHC antigens on freshly obtained melanoma cells in restricted mainly to cells which also express class I MHC antigensGoogle Scholar
  42. 42.
    Suter L, Bröcker EB, Brüggen J, Ruiter DJ, Sorg C (1983) Heterogeneity of primary and metastatic human malignant melanoma as detected with monoclonal antibodies in cryostat sections. Cancer Immunol Immunother 16:53–58PubMedCrossRefGoogle Scholar
  43. 43.
    Albino AP, Lloyd KO, Houghton AN, Oettgen HF, Old LJ (1981) Heterogeneity in surface antigen and glycoprotein expression of cell lines derived from different melanoma cells of the same patient. J Exp Med 154:1764–1778PubMedCrossRefGoogle Scholar
  44. 44.
    Natali PG, Cavaliere R, Bigotti A, Nicotra MR, Russo C, Ng AK, Giacomini P, Ferrone S (1983) Antigenic heterogeneity of surgically removed primary and autologous metastatic human melanoma. J Immunol 130:1462–1466PubMedGoogle Scholar
  45. 45.
    Burchiel SW, Martin JC, Imai K, Ferrone S, Warner NL (1982) Heterogeneity of HLA–A,B, Ia–like, and melanoma–associated antigen expression by human melanoma cell lines analyzed with monoclonal antibodies and flow cytometry. Cancer Res 42:4110–4115PubMedGoogle Scholar
  46. 46.
    Sarkar S, Glassy MC, Ferrone S, Jones OW (1980) Cell cycle and the differential expression of HLA–A,B and HLA–DR antigens on human B lymphoid cells. Proc Natl Acad Sci USA 77:7297–7301PubMedCrossRefGoogle Scholar
  47. 47.
    Fidler I J, Hart IR (1982) Biological diversity in metastatic neoplasms: origins and implications. Science 197:893–897CrossRefGoogle Scholar
  48. 48.
    Pollack MS, Chin–Louid J, Moshief RD (1984) Functional characteristics and differential expression of class IIDR, DS, and SB antigens on human melanoma cell lines. Human Immunol 9:75–82CrossRefGoogle Scholar
  49. 49.
    Sell S (1978) Cancer markers: diagnostic and developmental significance. In: Waters H (ed) Handbook of cancer immunology, vol 3. Garland STPM, New YorkGoogle Scholar
  50. 50.
    Houghton AN, Eisinger M, Albino AP, Cairncross JG, Old LJ (1982) Surface antigens of melanocytes and melanomas. Markers of melanocyte differentiation and melanoma subsets. J Exp Med 156:1755–1766PubMedCrossRefGoogle Scholar
  51. 51.
    Fitchen JH, Foon KA, Cline MH (1981) The antigenic characteristics of hematopoietic stem cells. N Engl J Med 305:17–25PubMedCrossRefGoogle Scholar
  52. 52.
    Pellegrino MA, Natali PG, Ng AK, Imai K, Russo C, Bigotti A, Wolf P, Ferrone S (1982) Unorthodox expression of Ia–like antigens on human tumor cells of nonlym–phoid origin: immunological properties, structural profile, significance and clinical relevance. In: Nakamura RM, Dito WR, Tucker ES (eds) Immunological analysis: recent progress in diagnostic Iaboratory immunology. Masson, New York, pp 159–173Google Scholar
  53. 53.
    Kornstein MJ, Brooks JSJ, Elder DE (1983) Immunoperoxidase localisation of lymphocyte subsets in the host response to melanoma and nevi. Cancer Res 43:2749–2754PubMedGoogle Scholar
  54. 54.
    Fossati G, Taramelli D, Dalsari A, Bogdanovich G, Andreola S, Parmiani G (1984) Primary but not metastatic human melanomas expressing DR antigens stimulate autologous lymphocytes. Int J Cancer 33:591–597PubMedCrossRefGoogle Scholar
  55. 55.
    Guerry IV DP, Alexander MA, Herlyn MD, Zehngebot LM, Mitchell KF, Zmijewski CM, Lusk EJ (1984) HLA–DR histocompatibility leukocyte antigens permit cultured human melanoma cells from early but not advanced disease to stimulate autologous lymphocytes. J Clin Invest 73:267–271PubMedCrossRefGoogle Scholar
  56. 56.
    Taramelli D, Fossati G, Balsari A, Marolda R, Parmiani G (1984) The inhibition of lymphocyte stimulation by autologous human metastatic melanoma cells correlates with the expression of HLA–DR antigens on the tumor cells. Int J Cancer 34:797–806PubMedCrossRefGoogle Scholar
  57. 57.
    Gonwa TA, Picker LJ, Raff HV, Goyert SM, Silver J, Stobo JD (1983) Antigen–presenting capabilities of human monocytes correlates with their expression of HLA–DS, an Ia determinant distinct from HLA–DR. J Immunol 130:706–711PubMedGoogle Scholar
  58. 58.
    McKean DJ, Infante AJ, Nilson A, Kimoto M, Fathman CG, Walker E, Warner N (1981) Major histocompatibility complex–restricted antigen presentation to antigen–reactive T cells by B lymphocyte tumor cells. J Exp Med 154:1419–1431PubMedCrossRefGoogle Scholar
  59. 59.
    Glimchez LH, Kim KJ, Green I, Paul WE (1982) Ia antigen–bearing B cell tumor lines can present protein antigen and alloantigen in a major histocompatibility complex–restricted fashion to antigen–reactive T cells. J Exp Med 155:445–459CrossRefGoogle Scholar
  60. 60.
    Guy K, Van Heyningen V, Ziegler A, Steel MC (1984) Disparity in HLA–DC antigen expression on chronic lymphocytic leucaemia cells. Dis Markers 2:287–293Google Scholar
  61. 61.
    Faille A, Turmel P, Charron DJ (1984) Differential expression of HLA–DR and HLA–DC/DS molecules in a patient with hairy cell leukaemia: restoration of HLA–DC/DS expression by (12–0–tetradeconyl phorbol–13–acetate), 5–azacytidine, and sodium bu–tyrate. Blood 64:33–38PubMedGoogle Scholar
  62. 62.
    Pellegrino MA, Ferrone S, Brautbar C, Hayflick L (1976) Changes in HLA antigen profiles on SV40 transformed human fibroblasts. Exp Cell Res 97:340PubMedCrossRefGoogle Scholar
  63. 63.
    Janeway CA Jr, Bottomly K, Babich J, Conrad P, Conzen S, Jones B, Kaye J, Katz M, McVay L, Murphy DB, Tite J (1984) Quantitative variation in Ia antigen expression plays a central role in immune regulation. Immunol Today 5:99–105CrossRefGoogle Scholar
  64. 64.
    Van Duinen SG (1984) Pathobiologic and diagnostic aspects of human cutaneous melanoma. Thesis, Leiden; Kanters, Alblasserdam, NetherlandsGoogle Scholar
  65. 65.
    Wilson BS, Imai K, Natali PG, Kay NE, Cavaliere R, Pellegrino MA, Ferrone S (1982) Immunochemical analysis of the antigenic profile of human melanoma cells with monoclonal antibodies. In: Reisfeld RA, Ferrone S (eds) Melanoma antigens and antibodies. Plenum, New York, pp 401–433Google Scholar
  66. 66.
    Alexander S, Hubbard SC, Strominger JL (1984) HLA–DR antigens of autologous melanoma and B lymphoblastoid cell lines: Differences in glycosylation but not protein structure. J Immunol 133:315–320PubMedGoogle Scholar
  67. 67.
    Ashewell G, Morell AG (1977) Carbohydrates on class II major histocompatibility complex antigens may mediate carbohydrate–specific recognition. Trends Biochem Sci 2:76CrossRefGoogle Scholar
  68. 68.
    Wilson BS, Glassy MC, Quaranta V, Ng AK, Ferrone S (1981) Effect of tunicamycin on the assembly and antigenicity of HLA antigens: analysis with monoclonal antibodies. Scand J Immunol 14:201–205PubMedCrossRefGoogle Scholar
  69. 69.
    Metzgar RS, Oleinick SR (1968) The study of normal and malignant cell antigens by mixed agglutination. Cancer Res 28:1366–1371PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • D. J. Ruiter
  • S. G. van Duinen
  • M. Tsujisaki
  • S. Ferrone

There are no affiliations available

Personalised recommendations