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Class II MHC Antigens and Hematopoiesis

  • V. C. Broudy
  • J. H. Fitchen

Abstract

Pluripotent hematopoietic stem cells have an extensive capacity for both self-renewal and for differentiation into progenitor cells committed to a single line of differentiation (Fig. 1) [1]. These committed progenitor cells have a limited capacity for self-renewal, and give rise to the mature cellular constituents of the peripheral blood (leukocytes, erythrocytes, and platelets). Progenitor cells comprise only a small portion (less than 0.1%) of the marrow cells [2]. They are not morphologically recognizable, but can be detected by their ability to form colonies of mature cells in semisolid media in vitro.

Keywords

Polycythemia Vera Hematopoietic Progenitor Cell Chronic Granulocytic Leukemia Pluripotent Hematopoietic Stem Cell Human Bone Marrow Culture 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Quesenberry P, Levitt L (1979) Hematopoietic stem cells. N Engl J Med 301:755, 819, 868CrossRefGoogle Scholar
  2. 2.
    Lord BI (1983) Hematopoietic stem cells. In: Potten CS (ed) Stem cells. Their identification and characterization. Churchill Livingstone, New York, p 118Google Scholar
  3. 3.
    Whang J, Frei E, Tjio JH, Carbone PJ, Brecher G (1983) The distribution of the Philadelphia chromosome in patients with chronic myelogenous leukemia. Blood 22:664Google Scholar
  4. 4.
    Golde DW, Burgaleta C, Sparkes RS, Cline MJ (1977) The Philadelphia chromosome in human macrophages. Blood 49:367PubMedGoogle Scholar
  5. 5.
    Adamson JW, Fialkow PJ, Murphy S, Prchal JF, Steinmann L (1976) Polycythemia vera: stem and probable clonal origin of the disease. N Engl J Med 295:913PubMedCrossRefGoogle Scholar
  6. 6.
    Fauser AA, Messner HA (1979) Identification of megakaryocytes, macrophages, and eosinophils in colonies of human bone marrow containing neutrophilic granulocytes and erythroblasts. Blood 53:1023PubMedGoogle Scholar
  7. 7.
    Prchal JT, Throckmorton DW, Carroll AJ, Fuson EW, Gams RA, Prchal JF (1978) A common progenitor for human myeloid and lymphoid cells. Nature 274:590PubMedCrossRefGoogle Scholar
  8. 8.
    Ogawa M, Porter PN, Nakahata T (1983) Renewal and commitment to differentiation of hematopoietic stem cells. Blood 61:823PubMedGoogle Scholar
  9. 9.
    Till JE, McCulloch EA, Siminovitch L (1964) A stochastic model of stem cell proliferation, based on the growth of spleen-colony forming cells. Proc Natl Acad Sci USA 51:29PubMedCrossRefGoogle Scholar
  10. 10.
    McCulloch EA (1983) Stem cells in normal and leukemic hematopoiesis. Blood 62:1PubMedGoogle Scholar
  11. 11.
    Suda T, Suda J, Ogawa M (1983) Single-cell origin of mouse hematopoietic colonies expressing multiple lineages in variable combinations. Proc Natl Acad Sci USA 80:6689PubMedCrossRefGoogle Scholar
  12. 12.
    Curry JL, Trentin J J (1967) Hematopoietic spleen colony studies: I. Growth and differentiation. Dev Biol 15:395PubMedCrossRefGoogle Scholar
  13. 13.
    VanZant G, Goldwasser E (1979) Competition between erythropoietin and colony-stimulating factor for target cells in mouse marrow. Blood 53:946Google Scholar
  14. 14.
    Burgess AW, Metcalf D (1980) The nature and action of granulocyte-macrophage colony stimulating factors. Blood 56:947PubMedGoogle Scholar
  15. 15.
    Golde DW, Cline MJ (1972) Identification of the colony-stimulating cell in human peripheral blood. J Clin Invest 51:2981PubMedCrossRefGoogle Scholar
  16. 16.
    Ruscetti FW, Chervenick PA (1975) Release of colony-stimulating activity from thymus-derived lymphocytes. J Clin Invest 55:520PubMedCrossRefGoogle Scholar
  17. 17.
    Bagby GC, Rigas VD, Bennett RM, Vandenbark AA, Garewal HS (1981) Interaction of lactoferrin, monocytes, and T lymphocyte subsets in the regulation of steady-state granulopoiesis in vitro. J Clin Invest 68:56PubMedCrossRefGoogle Scholar
  18. 18.
    Bagby GC, McCall E, Layman DL (1983) Regulation of colony-stimulating activity production. Interactions of fibroblasts, mononuclear phagocytes, and lactoferrin. J Clin Invest 71:340PubMedCrossRefGoogle Scholar
  19. 19.
    Quesenberry PT, Gimbrone MA (1980) Vascular endothelium as a regulator of granulopoiesis: production of colony-stimulating activity by cultured human endothelial cells. Blood 56:1060PubMedGoogle Scholar
  20. 20.
    Bagby GC, McCall E, Bergstrom KA, Burger D (1983) A monokine regulates colony-stimulating activity production by vascular endothelial cells. Blood 62:663PubMedGoogle Scholar
  21. 21.
    Harigaya K, Cronkite EP, Miller ME, Shadduck RK (1981) Murine bone marrow cell line producing colony-stimulating factor. Proc Natl Acad Sci USA 78:6963PubMedCrossRefGoogle Scholar
  22. 22.
    Garnett HM, Cronkite EP, Harigaya K (1982) Regulation of the colony-stimulating activity produced by a murine marrow-derived cell line (H-l). Proc Natl Acad Sci USA 79:1545PubMedCrossRefGoogle Scholar
  23. 23.
    Stanley ER, Heard PM (1977) Factors regulating macrophage production and growth. J Biol Chem 252:4305PubMedGoogle Scholar
  24. 24.
    Nicola NA, Metcalf D, Matsuomoto J, Johnson GR (1983) Purification of a factor inducing differentiation in murine myelomonocytic leukemia cells. J Biol Chem 258:9017PubMedGoogle Scholar
  25. 25.
    Griffin JD, Meuer SC, Schlossman SF, Reinherz EL (1984) T cell regulation of mye-lopoiesis: analysis at a clonal level. J Immunol 133:1863PubMedGoogle Scholar
  26. 26.
    Gough NM, Gough J, Metcalf D, Kelson A, Grail D, Nicola NA, Burgess AW, Dunn AR (1984) Molecular cloning of cDNA encoding a murine hematopoietic growth regulator, granulocyte-macrophage colony stimulating factor. Nature 309:763PubMedCrossRefGoogle Scholar
  27. 27.
    Johnson GR, Metcalf D (1977) Pure and mixed erythroid colony formation in vitro stimulated by spleen conditioned medium with no detectable erythropoietin. Proc Natl Acad Sci USA 74:3879PubMedCrossRefGoogle Scholar
  28. 28.
    Aye MT (1976) Erythroid colony formation in cultures of human marrow: effects of leukocyte conditioned medium. J Cell Physiol 91:69CrossRefGoogle Scholar
  29. 29.
    Ogawa M, Parmley RT, Bank HL, Spicer SS (1976) Human marrow erythropoiesis in culture. I. Characterization of methylcellulose colony assay. Blood 48:407PubMedGoogle Scholar
  30. 30.
    Tepperman AD, Curtis JE, McCulloch EA (1974) Erythropoietic colonies in cultures of human marrow. Blood 44:659PubMedGoogle Scholar
  31. 31.
    Zuckerman KS (1980) Stimulation of human BFU-E by products of human monocytes and lymphocytes. Exp Hematol 8:924PubMedGoogle Scholar
  32. 32.
    Zuckerman KS (1981) Human erythroid burst-forming units. Growth in vitro is dependent on monocytes, but not T lymphocytes. J Clin Invest 67:702PubMedCrossRefGoogle Scholar
  33. 33.
    Nathan DG, Chess L, Hillman DG, Clarke B, Breard J, Merler E, Housman DE (1978) Human erythroid burst-forming unit: T-cell requirement for proliferation in vitro. J Exp Med 147:324PubMedCrossRefGoogle Scholar
  34. 34.
    Werts ED, DeGowin RL, Knapp SK, Gibson DP (1980) Characterization of marrow stromal (fibroblastoid) cells and their association with erythropoiesis. Exp Hematol 8:423PubMedGoogle Scholar
  35. 35.
    McCall E, Bagby GC (1985) Monocyte derived recruiting activity: kinetics of production and effects of endotoxin. Blood 65:689PubMedGoogle Scholar
  36. 36.
    Fung MC, Hapel AJ, Ymer S, Cohen DR, Johnson RM, Campbell HD, Young IG (1984) Molecular cloning of cDNA for murine interleukin-3. Nature 307:233PubMedCrossRefGoogle Scholar
  37. 37.
    Gregory CJ (1976) Erythropoietin sensitivity as a differentiation marker in the hematopoietic system: studies of three erythropoietic colony responses in culture. J Cell Physiol 89:289PubMedCrossRefGoogle Scholar
  38. 38.
    McLeod DL, Shreeve MM, Axelrad AA (1974) Improved plasma culture system for production of erythrocytic colonies in vitro: quantitative assay method for CFU-E. Blood 44:517PubMedGoogle Scholar
  39. 39.
    Broudy V, Zuckerman K, Jetmalani S, Fitchen J, Bagby GC (1984) The production of burst promoting activity (BPA) and colony stimulating activity (CSA) by adherent fibroblastoid marrow cells (F) is regulated by autologous monocytes. Clin Res 32:305AGoogle Scholar
  40. 40.
    Broxmeyer HE, Smithyman A, Eger RR, Myers RA, DeSousa M (1978) Identification of lactoferrin as the granulocyte-derived inhibitor of colony-stimulating activity production. J Exp Med 148:1052PubMedCrossRefGoogle Scholar
  41. 41.
    Broxmeyer HE, DeSousa M, Smithyman A, Ralph P, Hamilton J, Kurland J, Bognacki J (1980) Specificity and modulation of the action of lactoferrin, a negative feedback regulator of myelopoiesis. Blood 55:324PubMedGoogle Scholar
  42. 42.
    Pelus LM, Broxmeyer HE, Kurland JI, Moore MAS (1979) Regulation of macrophage and granulocyte proliferation. Specificities of prostaglandin E and lactoferrin. J Exp Med 150:277PubMedCrossRefGoogle Scholar
  43. 43.
    Taetle R, Koessler A (1980) Effects of cyclic nucleotides and prostaglandins in normal and abnormal human myeloid progenitor cell proliferation. Cancer Res 40:1223PubMedGoogle Scholar
  44. 44.
    Pelus LM, Broxmeyer HE, Moore MAS (1981) Regulation of human myelopoiesis by prostaglandin E and lactoferrin. Cell Tissue Kinet 14:515PubMedGoogle Scholar
  45. 45.
    Broxmeyer HE, Jacobsen N, Kurland J, Mendelsohn N, Moore MAS (1978) In vitro suppression of normal granulocytic stem cells by inhibitory activity derived from human leukemia cells. J Natl Cancer Inst 60:497PubMedGoogle Scholar
  46. 46.
    Broxmeyer HE, Bognacki J, Dorner MH, DeSousa M (1981) Identification of leukemia associated inhibitory activity as acidic isoferritins. J Exp Med 153:1426PubMedCrossRefGoogle Scholar
  47. 47.
    Broxmeyer HE, Bognacki J, Ralph P, Dorner MH, Lu L, Castro-Malaspina H (1982) Monocyte-macrophage-derived acidic isoferritins: normal feed-back regulators of granulocyte-macrophage progenitor cells in vitro. Blood 60:595PubMedGoogle Scholar
  48. 48.
    Jacobs A (1983) Do acidic isoferritins regulate hematopoiesis? Br J Haematol 55:199PubMedCrossRefGoogle Scholar
  49. 49.
    Broxmeyer HE, Juliano L, Lu L, Platzer E, Dupont B (1984) HLA-DR human histocompatibility leukocyte antigens-restricted lymphocyte-monocyte interactions in the release from monocytes of acidic isoferritins that suppress hematopoietic progenitor cells. J Clin Invest 73:939PubMedCrossRefGoogle Scholar
  50. 50.
    Goodman JW, Goodman DR (1983) Involvement of cells of the immune system in regulation of erythropoiesis. In: Dunn CDR (ed) Current concepts in erythropoiesis. Wiley, Chichester, p 59Google Scholar
  51. 51.
    Mangan KF, Desforges JF (1980) The role of T lymphocytes and monocytes in the regulation of human erythropoietic peripheral blood burst forming units. Exp Haematol 8:717Google Scholar
  52. 52.
    Nomdedeu B, Gormus BT, Banisadre M, Rinehart J J, Kaplan ME, Zanjani ED (1980) Human peripheral blood erythroid burst forming unit (BFUE): evidence against T-lymphocyte requirement for proliferation in vitro. Exp Haematol 8:845Google Scholar
  53. 53.
    Gordon LI, Miller WJ, Branda RF, Zanjani ED, Jacob HS (1980) Regulation of erythroid colony formation by bone marrow macrophages. Blood 55:1047PubMedGoogle Scholar
  54. 54.
    Reid CDL, Baptista LC, Chanarin I (1981) Erythroid colony growth in vitro from human peripheral blood null cells: evidence for regulation by T-lymphocytes and monocytes. Br J Haematol 48:155PubMedCrossRefGoogle Scholar
  55. 55.
    Clarke BJ, Harvey AR, Kaiser J, Leeds C (1984) Quantitative analysis of the role of accessory cells in the development of human blood BFU-E-derived erythroid colonies. Exp Haematol 12:259Google Scholar
  56. 56.
    Linch DC, Nathan DG (1984) T cell and monocyte-derived burst-promoting activity directly act on erythroid progenitor cells. Nature 312:775PubMedCrossRefGoogle Scholar
  57. 57.
    Zuckerman KS, Bagby GC, McCall E, Sparks B, Wells J, Patel V, Goodrum D (1985) A monokine stimulates production of human erythroid burst-promoting activity by endothelial cells in vitro. J Clin Invest 75:722PubMedCrossRefGoogle Scholar
  58. 58.
    Rossi GB, Mighiaccio AR, Mighiaccio G, Lettieri F, DiRosa M, Mastroherardino G, Peschle C (1980) In vitro interaction of PGE and CAMP with murine and human erythroid precursors. Blood 56:74PubMedGoogle Scholar
  59. 59.
    DeGowin RL, Gibson DP (1981) Prostaglandin-mediated enhancement of erythroid colonies by marrow stromal cells (MSC). Exp Haematol 9:274Google Scholar
  60. 60.
    Lu L, Pelus LM, Broxmeyer HE (1984) Modulation of the expression of HLA-DR (la) antigens and the proliferation of human erythroid (BFU-E) and multipotential (CFU-GEMM) progenitor cells by prostaglandin E. Exp Haematol 12:741Google Scholar
  61. 61.
    Sieff C, Bicknell D, Caine G, Robinson J, Lam G, Greaves MF (1982) Changes in cell surface antigen expression during hematopoietic differentiation. Blood 60:703PubMedGoogle Scholar
  62. 62.
    Robinson J, Sieff C, Delia D, Edwards PAW, Greaves M (1981) Expression of cell-surface HLA-DR, HLA-ABC and glycophorin during erythroid differentiation. Nature 289:68PubMedCrossRefGoogle Scholar
  63. 63.
    Fitchen JH, Foon KA, Cline MJ (1981) The antigenic characteristics of hematopoietic stem cells. N Engl J Med 305:17PubMedCrossRefGoogle Scholar
  64. 64.
    Linch DC, Nadler LM, Luther EA, Lipton JM (1984) Discordant expression of human Ia-like antigens on hematopoietic progenitor cells. J Immunol 132:2324PubMedGoogle Scholar
  65. 65.
    Fitchen JH, Russo C, Ferrone S (1984) Complement-dependent killing of human hematopoietic progenitor cells with noncomplement-fixing monoclonal antibodies in an antiglobulin assay. Blood 63:873PubMedGoogle Scholar
  66. 66.
    Moore MAS, Broxmeyer HE, Sheridan APC, Meyers PA, Jacobsen N, Winchester RJ (1980) Continuous human bone marrow culture: la antigen characterization of probable pluripotential stem cells. Blood 55:682PubMedGoogle Scholar
  67. 67.
    Andrews RG, Takahashi M, Segal G, Powell J, Bernstein ID, Singer JW (1984) Progenitors of CFU-GM in long term marrow culture (LTBMC) express the 4.1 (HLA-DR) but not the L4F3 antigen. Blood 64 (Suppl 1): 110 aGoogle Scholar
  68. 68.
    Gartner S, Kaplan HS (1980) Long-term culture of human bone marrow cells. Proc Natl Acad Sci USA 77:4756PubMedCrossRefGoogle Scholar
  69. 69.
    Keating A, Powell J, Takahashi M, Singer JW (1984) The generation of human long-term marrow culture from marrow depleted of la (HLA-DR) positive cells. Blood 64:1159PubMedGoogle Scholar
  70. 70.
    Fitchen JH, LeFevre C, Ferrone S, Cline MJ (1982) Expression of la-like and HLA-A,B antigens on human multipotential hematopoietic progenitor cells. Blood 59:188PubMedGoogle Scholar
  71. 71.
    Bodger MP, Izaguirre CA, Blacklock HA, Hoffbrand AV (1983) Surface antigenic determinants on human pluripotent and unipotent hematopoietic progenitor cells. Blood 61:1006PubMedGoogle Scholar
  72. 72.
    Falkenburg JHF, Jansen J, van der Vaart-Duinkerken N, Veenhoff WFJ, Blotkamb J, Goselink HM, Parlevliet J, vanRood JJ (1984) Polymorphic and monomorphic HLA-DR determinants on human hematopoietic progenitor cells. Blood 63:1125PubMedGoogle Scholar
  73. 73.
    Lu L, Broxmeyer HE, Meyers PA, Moore MAS, Thaler HT (1983) Association of cell cycle expression of la-like antigenic determinants on normal human multipotential (CFU-GEMM) and erythroid (BFU-E) progenitor cells with regulation in vitro by acidic isoferritins. Blood 61:250PubMedGoogle Scholar
  74. 74.
    Fitchen JH, Ferrone S, Quaranta V, Molinaro GA, Cline MJ (1980) Monoclonal antibodies to HLA-A,B, and la-like antigens inhibit colony formation by human myeloid progenitor cells. J Immunol 125:2004PubMedGoogle Scholar
  75. 75.
    Levine MN, Fay JW, Jones NH, Metzgar RS, Haynes BF (1981) Phenotypic characterization of human bone marrow granulocyte-macrophage forming progenitor cells. Blood 58:1047PubMedGoogle Scholar
  76. 76.
    Greenberg P, Grossman M, Charron D, Levy R (1981) Characterization of antigenic determinants on human myeloid colony forming cells with monoclonal antibodies. Exp Haematol 9:781Google Scholar
  77. 77.
    Winchester RJ, Ross GD, Jarowski CI, Wang CY, Halper J, Broxmeyer HE (1977) Expression of la-like antigen molecules on human granulocytes during early phases of differentiation. Proc Natl Acad Sci USA 74:4012PubMedCrossRefGoogle Scholar
  78. 78.
    Pelus LM (1982) Association between colony forming units-granulocyte macrophage expression of la-like (HLA-DR) antigens and control of granulocyte and macrophage production. A new role for prostaglandin E. J Clin Invest 70:568PubMedCrossRefGoogle Scholar
  79. 79.
    Pelus LM, Saletan S, Silver R, Moore MAS (1982) Expression of la-antigens on normal and chronic myeloid leukemia human granulocyte-macrophage colony-forming cells (CFU-GM) is associated with regulation of cell proliferation by prostaglandin E. Blood 59:284PubMedGoogle Scholar
  80. 80.
    Torok-Storb B, Nepom GT, Nepom BS, Hansen JA (1983) HLA-DR antigens on lymphoid cells differ from those on myeloid cells. Nature 305:541PubMedCrossRefGoogle Scholar
  81. 81.
    Fitchen JH, Burger DR (1983) Heterogeneity of la antigen density on human granulocyte-macrophage progenitor cells (CFU-G,M). Blood 62 (Suppl l):134aGoogle Scholar
  82. 82.
    Broxmeyer HE (1982) Relationship of cell-cycle expression of la-like antigenic determinants on normal and leukemia human granulocyte-macrophage progenitor cells to regulation in vitro by acidic isoferritins. J Clin Invest 69:632PubMedCrossRefGoogle Scholar
  83. 83.
    Cannistra SA, Daley JF, Larcom P, Griffin JD (1985) Expression of la antigens on myeloid progenitor cells in chronic myeloid leukemia: direct analysis using partially purified colony-forming cells. Blood 65:414PubMedGoogle Scholar
  84. 84.
    Belzer MB, Fitchen JH, Ferrone S, Foon KA, Billing RJ, Golde DW (1981) Expression of la-like antigens on human erythroid progenitor cells as determined by monoclonal antibodies and heteroantisera to la-like antigens. Clin Immunol Immunopathol 20:111PubMedCrossRefGoogle Scholar
  85. 85.
    Goldman JM, Hibbin J, Kearney K, Orchard K, Th’ng KH (1982) HLA-DR monoclonal antibodies inhibit proliferation of normal and chronic granulocytic leukemia myeloid progenitor cells. Br J Haematol 52:411PubMedCrossRefGoogle Scholar
  86. 86.
    Griffin JD, Beveridge RP, Schlossman SF (1982) Isolation of myeloid progenitor cells from peripheral blood of chronic myelogenous leukemia patients. Blood 60:30PubMedGoogle Scholar
  87. 87.
    Schwamborn JS, Ferrone S, Burger DR, Fitchen JH (1984) Altered expression of la antigens on monocytes and granulocyte-macrophage progenitors (CFU-GM) from patients with chronic granulocytic leukemia (CGL). Blood 64 [Suppl l]:198aGoogle Scholar
  88. 88.
    Ferrero R, Broxmeyer HE, Pagliardi GL, Venuta S, Lange B, Pessano S, Rovera G (1983) Antigenically distinct subpopulations of myeloid progenitor cells (CFU-GM) in human peripheral blood and marrow. Proc Natl Acad Sci USA 80:4114Google Scholar
  89. 89.
    Torok-Storb B, Papyannopoulou T (1981) Polycythemia vera: abnormal patterns of cell surface antigen expression on endogenous CFU-E. Blood 58 (Suppl l):92aGoogle Scholar
  90. 90.
    Torok-Storb B, Hansen JA (1982) Modulation of in vitro BFU-E growth by normal la-positive T cells is restricted by HLA-DR. Nature 298:473PubMedCrossRefGoogle Scholar
  91. 91.
    Kurland JI, Bockman RS, Broxmeyer HE, Moore MAS (1978) Limitation of excessive myelopoiesis by the intrinsic modulation of macrophage derived prostaglandin E. Science 199:552PubMedCrossRefGoogle Scholar
  92. 92.
    Gentile P, Byer D, Pelus LM (1983) In vivo modulation of murine myelopoiesis following intravenous administration of prostaglandin E. Blood 62:1100Google Scholar
  93. 93.
    Pelus LM, Gold E, Saletan S, Coleman M (1983) Restoration of responsiveness of chronic myeloid leukemia granulocyte-macrophage colony-forming cells to growth regulation in vitro following preincubation with prostaglandin E. Blood 62:158PubMedGoogle Scholar
  94. 94.
    Schwamborn JS, Ferrone S, Fitchen JH (1984) Prostaglandin E (PGE)-mediated inhibition of granulocyte-macrophage progenitors (CFU-GM) from patients with chronic granulocytic leukemia. Blood 64 [Suppl l]:198aGoogle Scholar
  95. 95.
    Torok-Storb B, Martin PJ, Hansen J A (1981) Regulation of in vitro erythropoiesis by normal T cells: evidence for two T-cell subsets with opposing function. Blood 58:171PubMedGoogle Scholar
  96. 96.
    Lipton JM, Nadler LM, Canellos GP, Kudisch M, Reiss CS, Nathan DG (1983) Evidence for genetic restriction in the suppression of erythropoiesis by a unique subset of T lymphocytes in man. J Clin Invest 72:694PubMedCrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • V. C. Broudy
  • J. H. Fitchen

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