Class II MHC Antigens and Hematopoiesis

  • V. C. Broudy
  • J. H. Fitchen


Pluripotent hematopoietic stem cells have an extensive capacity for both self-renewal and for differentiation into progenitor cells committed to a single line of differentiation (Fig. 1) [1]. These committed progenitor cells have a limited capacity for self-renewal, and give rise to the mature cellular constituents of the peripheral blood (leukocytes, erythrocytes, and platelets). Progenitor cells comprise only a small portion (less than 0.1%) of the marrow cells [2]. They are not morphologically recognizable, but can be detected by their ability to form colonies of mature cells in semisolid media in vitro.


Polycythemia Vera Hematopoietic Progenitor Cell Chronic Granulocytic Leukemia Pluripotent Hematopoietic Stem Cell Human Bone Marrow Culture 
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© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • V. C. Broudy
  • J. H. Fitchen

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