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Physiologic Regulation of Class II Major Histocompatibility Complex Gene Expression

  • Chapter
HLA Class II Antigens

Abstract

T inducer (helper) cells can only recognize antigen in association with class II major histocompatibility complex (MHC) antigens on the surface of an antigen-presenting cell [11]. The T cell antigen receptor, in addition to recognizing polymorphic self-class II determinants modified by nominal antigen, can recognize foreign polymorphic (allogeneic) class II determinants, with or without nominal antigen [107]. Recognition of foreign class II determinants generates alloactivated T helper cells which are involved in generating specific effector cells. Inducible expression of class II antigens may confer accessory capacity upon cells not generally thought of as components of the immune system. Such cells could either present nominal antigen or, in the case of transplantation, stimulate an allogeneic response. Therefore, mechanisms regulating the expression of these proteins may play a crucial role in modulating immune responsiveness. To understand possible regulatory mechanisms, a knowledge of the general structural features of these proteins and the coresponding genes is important.

This work was supported by National Institutes of Health grants HL27642, HL22602, AM13230, AM30241, and 5T32 HL07066. J.S.P. is a Searle Scholar

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Authors
  1. T. Collins
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  2. J. S. Pober
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  3. J. L. Strominger
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Editor information

Editors and Affiliations

  1. Blood Bank and Immunohematological Laboratory, Rikshospitalet, National Hospital, Pilestredet 32, N-0027, Oslo 1, Norway

    Bjarte G. Solheim (Director) (Director)

  2. Karolinska Institute, Department of Clinical Immunology, Huddinge Hospital, S-14186, Huddinge, Sweden

    Erna Møller

  3. Dept. of Microbiology and Immunology, New York Medical College, Valhalla, NY, 10595, USA

    Soldano Ferrone

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© 1986 Springer-Verlag Berlin Heidelberg

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Collins, T., Pober, J.S., Strominger, J.L. (1986). Physiologic Regulation of Class II Major Histocompatibility Complex Gene Expression. In: Solheim, B.G., Møller, E., Ferrone, S. (eds) HLA Class II Antigens. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70367-6_2

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  • DOI: https://doi.org/10.1007/978-3-642-70367-6_2

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  • Online ISBN: 978-3-642-70367-6

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