Physiologic Regulation of Class II Major Histocompatibility Complex Gene Expression

  • T. Collins
  • J. S. Pober
  • J. L. Strominger

Abstract

T inducer (helper) cells can only recognize antigen in association with class II major histocompatibility complex (MHC) antigens on the surface of an antigen-presenting cell [11]. The T cell antigen receptor, in addition to recognizing polymorphic self-class II determinants modified by nominal antigen, can recognize foreign polymorphic (allogeneic) class II determinants, with or without nominal antigen [107]. Recognition of foreign class II determinants generates alloactivated T helper cells which are involved in generating specific effector cells. Inducible expression of class II antigens may confer accessory capacity upon cells not generally thought of as components of the immune system. Such cells could either present nominal antigen or, in the case of transplantation, stimulate an allogeneic response. Therefore, mechanisms regulating the expression of these proteins may play a crucial role in modulating immune responsiveness. To understand possible regulatory mechanisms, a knowledge of the general structural features of these proteins and the coresponding genes is important.

Keywords

Influenza Interferon Prostaglandin Disulfide Myeloma 

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© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • T. Collins
  • J. S. Pober
  • J. L. Strominger

There are no affiliations available

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