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Cellular Detection of Human Class II Antigens: Delineation of a Novel HLA-DP-like Suppressor Restriction System DY, the Sequential Expression of Class II Antigens, and a Pronounced Functional Flexibility of Class II Alloproliferative T Cell Clones

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HLA Class II Antigens

Abstract

HLA class II gene products, encoded on the short arm of chromosome 6 in the region of 6p21.33 [1], are expressed with limited tissue distribution on the surfaces of immunologically active cells, predominantly B lymphocytes, monocytes, dendritic cells, and macrophages [2, 3]. They are in addition synthesized and expressed by certain other types of cells, notably activated T lymphocytes [4], and various kinds of endothelia and epithelia, especially after induction by agents such as gamma-interferon [5]. Class II antigens are of critical importance for the initiation of immune responses, since at least the majority of T helper cells fails to recognize antigen unless both class II molecules and antigen are available on the surface of the same antigen-presenting cell [6]. Allogeneic class II products stimulate T cell proliferative responses in the apparent absence of additional antigen by virtue of their polymorphism. Although the basis of alloreactivity is not fully understood, the restriction elements for antigen presentation correlate closely with the class II specificities defined by alloreactive T cells, making it fair to assume that the same gene products, and possibly even identical epitopes, are involved in both recognition systems [7, 8].

This “DP-like” Restriction System has been named DY

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  1. P. Wernet
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  2. G. Pawelec
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  3. E. M. Schneider
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Editors and Affiliations

  1. Blood Bank and Immunohematological Laboratory, Rikshospitalet, National Hospital, Pilestredet 32, N-0027, Oslo 1, Norway

    Bjarte G. Solheim (Director) (Director)

  2. Karolinska Institute, Department of Clinical Immunology, Huddinge Hospital, S-14186, Huddinge, Sweden

    Erna Møller

  3. Dept. of Microbiology and Immunology, New York Medical College, Valhalla, NY, 10595, USA

    Soldano Ferrone

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Wernet, P., Pawelec, G., Schneider, E.M. (1986). Cellular Detection of Human Class II Antigens: Delineation of a Novel HLA-DP-like Suppressor Restriction System DY, the Sequential Expression of Class II Antigens, and a Pronounced Functional Flexibility of Class II Alloproliferative T Cell Clones. In: Solheim, B.G., Møller, E., Ferrone, S. (eds) HLA Class II Antigens. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70367-6_16

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  • DOI: https://doi.org/10.1007/978-3-642-70367-6_16

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