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Pharmacological Aspects of Fetal Heart Rate Regulation During Hypoxia

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Fetal Heart Rate Monitoring

Abstract

Reduction in the level of fetal oxygenation can produce a variety of changes in the fetal heart rate (FHR). In addition to the degree and duration of the lack of oxygen, other factors which can influence the FHR response to hypoxia include the age of the fetus, its condition at the onset of the hypoxic stress, and the presence and degree of hypercapnia and acidemia accompanying the hypoxia. Hypoxia can affect the FHR by reflex mechanisms involving both major divisions of the autonomic nervous system, by stimulating the release of catecholamines from the adrenal medulla and by direct depression of myocardial rhythmicity. The FHR can be influenced indirectly by hypoxia-induced changes in brain activity state, breathing, and somatic movements.

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References

  • Barcroft J (1946) Researches on prenatal life. Blackwell, Oxford

    Google Scholar 

  • Berman W, Goodlin RC, Heymann MA, Rudolph MA (1976) Relationship between pressure and flow in the umbilical and uterine circulations of the sheep. Circ Res 38:262

    PubMed  Google Scholar 

  • Blanco CE, Walker DW (1982) Effect of hypoxaemia on hind limb reflexes in unanesthetized fetal and newborn lambs. J Physiol 320:125

    Google Scholar 

  • Blanco CE, Dawes GS, Hanson M, McCooke HB (1982) The arterial chemoreceptors in fetal sheep and newborn lambs. J Physiol 330:38

    Google Scholar 

  • Boddy K, Dawes GS, Fisher R, Pinter S, Robinson JS (1974) Fetal respiratory movements, electro-cortical and cardiovascular responses to hypoxaemia and hypercapnia in sheep. J Physiol 243:599

    PubMed  CAS  Google Scholar 

  • Clewlow F, Dawes GS, Johnston BM, Walker DW (1983) Changes in breathing, electrocortical and muscle activity in unanaesthetized fetal lambs with age. J Physiol 341:463

    PubMed  CAS  Google Scholar 

  • Cohn HE, Piasecki GJ, Jackson BT (1978) The role of autonomic nervous control in the fetal cardiovascular response to hypoxemia. In: Longo LD, Reneau DD (eds) Fetal and newborn cardiovascular physiology, vol 2. Garland STPM, New York, p 249

    Google Scholar 

  • Cohn HE, Piasecki GJ, Jackson BT (1982) The effect of β-adrenergic stimulation on fetal cardiovascular function during hypoxemia. Am J Obstet Gynecol 144:810

    PubMed  CAS  Google Scholar 

  • Court DJ, Block BS, Llanos AJ, Parer JT (1983) The effects of propranolol on blood flow redistribution in hypoxemic fetal sheep. Society for Gynecologic Investigation (Abstracts), p 126

    Google Scholar 

  • Dalton KJ, Dawes GS, Patrick JE (1977) Diurnal, respiratory and other rhythms of fetal heart rate in lambs. Am J Obstet Gynecol 127:414

    PubMed  CAS  Google Scholar 

  • Dawes GS, Lewis BV, Milligan JE, Roach ML, Talner NS (1968) Vasomotor responses in the hind limbs of foetal and newborn lambs to asphyxia and aortic chemoreceptor stimulation. J Physiol 195:55

    PubMed  CAS  Google Scholar 

  • De Haan J, Van Bemmel JH, Versteeg B, Veth AFL, Stolte LAM, Janssens J, Eskes TKAB (1971) Quantitative evaluation of fetal heart rate patterns. I. Processing methods. Eur J Obstet Gynecol Reprod Biol 1:95

    Google Scholar 

  • Druzin ML, Ikenoue T, Murata Y, Socol M, Martin CB (1979) A possible mechanism for the increase in fetal heart rate variability following hypoxemia. Society for Gynecologic Investigation (Abstracts), p 91

    Google Scholar 

  • Evers JLH, De Haan J, Jongsma HW, Crevels J, Arts THM, Martin CB (1981a) The preejection period of the fetal cardiac cycle. 1. Umbilical cord occlusions. Eur J Obstet Gynecol Reprod Biol 11:401

    Article  PubMed  CAS  Google Scholar 

  • Evers JLH, De Haan J, Jongsma HW, Crevels J, Arts THM, Martin CB (1981b) The preejection period of the fetal cardiac cycle. 2. Maternal common internal iliac artery occlusions. Eur J Obstet Gynecol Reprod Biol 11:419

    Article  PubMed  CAS  Google Scholar 

  • Harris JL, Krueger TR, Parer JT (1979) Effects of parasympathetic and β-adrenergic blockade on the umbilical circulation in the unanesthetized fetal sheep. Gynecol Obstet Invest 10:306

    Article  PubMed  CAS  Google Scholar 

  • Harris JL, Krueger TR, Parer JT (1981) Mechanism of late decelerations: effect of alpha-adrenergic blockade. Society for Gynecologic Investigation (Abstracts), p 164

    Google Scholar 

  • Harris JL, Krueger TR, Parer JT (1982) Mechanisms of late decelerations of the fetal heart rate during hypoxia. Am J Obstet Gynecol 144:491

    PubMed  CAS  Google Scholar 

  • Ikenoue T, Martin CB, Murata Y, Ettinger BB, Lu PS (1981) Effect of acute hypoxemia and respiratory acidosis on the fetal heart rate in monkeys. Am J Obstet Gynecol 141:797

    PubMed  CAS  Google Scholar 

  • Itskovitz J, Goetzman BW, Rudolph AM (1982) The mechanism of late deceleration of the heart rate and its relationship to oxygenation in normoxemic and chronically hypoxemic fetal lambs. Am J Obstet Gynecol 142:66

    PubMed  CAS  Google Scholar 

  • Itskovitz J, La Gamma EF, Bristow J, Rudolph AM (1983) Role of arterial chemoreflex in fetal circulatory response to acute hypoxemia. Society for Gynecologic Investigation (Abstracts), p 126

    Google Scholar 

  • Iwamoto HS, Rudolph AM, Keil LC, Heymann MA (1979) Hemodynamic responses of the sheep fetus to vasopressin infusion. Circ Res 44:430

    PubMed  CAS  Google Scholar 

  • Jones CT, Ritchie JWK (1978) The cardiovascular effects of circulating catecholamines in fetal sheep. J Physiol 285:381

    PubMed  CAS  Google Scholar 

  • Jones CT, Ritchie JWK (1983) The effects of adrenergic blockade on fetal response to hypoxia. J Dev Physiol 5:211

    PubMed  CAS  Google Scholar 

  • Jones CT, Robinson RO (1975) Plasma catecholamines in foetal and adult sheep. J Physiol 248:15

    PubMed  CAS  Google Scholar 

  • La Gamma EL, Itskovitz J, Rudolph AM (1982) Effects of naloxone on fetal circulatory responses to hypoxia. Am J Obstet Gynecol 143:933

    Google Scholar 

  • Lewis AB, Wolf WJ, Sischo W (1983) Fetal cardiovascular and catecholamine responses to hypoxia after chemical sympathectomy. Pediatr Res 17:136

    Google Scholar 

  • Martin CB Jr, DeHaan J, Van Der Wildt B, Jongsma HW, Dieleman A, Arts THM (1979a) Mechanisms of late decelerations in the fetal heart rate. A study with autonomic blocking agents in fetal lambs. Eur J Obstet Gynecol Reprod Biol 9:361–373

    Article  PubMed  Google Scholar 

  • Martin CB, DeHaan J, Jongsma HW, Van Der Wildt B, Evers JLH, Dieleman A, Arts THM (1979b) Quantitative investigation of the effect of hypoxemia on FHR variability indices in fetal lambs. Society for Gynecologic Investigation (Abstracts), p 193

    Google Scholar 

  • Parer JT (1979) Effect of atropine on heart rate and oxygen consumption of the hypoxic fetus. Gynecol Invest 8:50

    Google Scholar 

  • Parer JT, Laros RK, Heilbron DC, Krueger TR, Rubsamen RM, Wong WS (1979) The effect of acute hypoxia hypercarbia on fetal heart rate variability in awake monkeys. Society for Gynecologic Investigation (Abstracts), p 93

    Google Scholar 

  • Parer JT, Dijkstra HR, Vredebregt PPM, Harris JL, Krueger TR, Reuss ML (1980a) Increased fetal heart rate variability with acute hypoxia in chronically instrumented sheep. Eur J Obstet Gynecol Reprod Biol 10:393

    Article  PubMed  CAS  Google Scholar 

  • Parer JT, Krueger TR, Harris JL (1980b) Fetal oxygen consumption and mechanisms of heart rate response during artificially produced late decelerations of fetal heart rate in sheep. Am J Obstet Gynecol 136:478

    PubMed  CAS  Google Scholar 

  • Reuss ML, Parer JT, Harris JL, Krueger TR (1982) Hemodynamic effects of alpha-adrenergic blockade during hypoxia in fetal sheep. Am J Obstet Gynecol 142:410

    PubMed  CAS  Google Scholar 

  • Rurak DW (1978) Plasma vasopressin levels during hypoxemia and the cardiovascular effects of exogenous vasopressin in foetal and adult sheep. J Physiol 277:341

    PubMed  CAS  Google Scholar 

  • Stark RL, Wardlaw SL, Daniel SS, Husain MK, Sanocka UM, James LS, Van De Wiele RL (1982) Vasopressin secretion induced by hypoxia in sheep: developmental changes and relationship to β-endorphin release. Am J Obstet Gynecol 143:204

    PubMed  CAS  Google Scholar 

  • Van Der Wildt B (1982) Heart rate, breathing movements and brain activity in fetal lambs. Doctoral thesis, Catholic University, Nijmegen, The Netherlands

    Google Scholar 

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© 1985 Springer-Verlag Berlin Heidelberg

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Martin, C.B. (1985). Pharmacological Aspects of Fetal Heart Rate Regulation During Hypoxia. In: Künzel, W. (eds) Fetal Heart Rate Monitoring. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70358-4_18

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  • DOI: https://doi.org/10.1007/978-3-642-70358-4_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70360-7

  • Online ISBN: 978-3-642-70358-4

  • eBook Packages: Springer Book Archive

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