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Vascular Endothelium: The Interface Between the Site of Antigen and Cellular Immunity

  • D. R. Burger
  • C. R. Wagner
  • R. M. Vetto
Conference paper
Part of the Bayer-Symposium book series (BAYER-SYMP, volume 8)

Summary

Endothelial cells line the vessels and lymphatics, forming a barrier between circulating T cells and the extravascular tissue site of antigen. We have suggested that circulating T cells recognize antigen on the surface of endothelial cells, resulting in the activation of the endothelium such that the endothelial cells then release the key mediators of a cell-mediated immune response. To test this hypothesis we have evaluated the extent to which endothelial cells can signal antigen-specific T cell activation. We have shown that cultured endothelial cells are as effective as macrophages in lymphocyte activation and that this activation is HLA-DR restricted. In additional experiments, we have established that endothelial cells synthesize both Ia and IL-1 early in the signaling process. To eliminate any possible contribution of other cell types participating in the T cell-endothelial cell interaction, we have shown that cloned endothelial cells present antigen to cloned T cells. These experiments document that endothelial cells are independently competent antigen-presenting cells.

Keywords

Endothelial Cell Cell Clone Imperial Cancer Research Fund Tuberculin Response Compatible Endothelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • D. R. Burger
  • C. R. Wagner
  • R. M. Vetto

There are no affiliations available

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