Summary
Endothelial cells line the vessels and lymphatics, forming a barrier between circulating T cells and the extravascular tissue site of antigen. We have suggested that circulating T cells recognize antigen on the surface of endothelial cells, resulting in the activation of the endothelium such that the endothelial cells then release the key mediators of a cell-mediated immune response. To test this hypothesis we have evaluated the extent to which endothelial cells can signal antigen-specific T cell activation. We have shown that cultured endothelial cells are as effective as macrophages in lymphocyte activation and that this activation is HLA-DR restricted. In additional experiments, we have established that endothelial cells synthesize both Ia and IL-1 early in the signaling process. To eliminate any possible contribution of other cell types participating in the T cell-endothelial cell interaction, we have shown that cloned endothelial cells present antigen to cloned T cells. These experiments document that endothelial cells are independently competent antigen-presenting cells.
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References
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© 1985 Springer-Verlag Berlin Heidelberg
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Burger, D.R., Wagner, C.R., Vetto, R.M. (1985). Vascular Endothelium: The Interface Between the Site of Antigen and Cellular Immunity. In: Jackson, G.G., Thomas, H. (eds) The Pathogenesis of Bacterial Infections. Bayer-Symposium, vol 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70351-5_25
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DOI: https://doi.org/10.1007/978-3-642-70351-5_25
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-70353-9
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