Abstract
The study of the pharmacological properties of antiasthmatic drugs has deeply influenced ideas concerning the pathophysiology and pathogenesis of asthma. New findings on the pathogenesis of asthma influence the hypotheses involving the mode of action of antiasthmatic drugs. A discussion on the physiopathological treatment of bronchial asthma, therefore, is based on current thinking about the pathophysiology of bronchial asthma. The main characteristic of bronchial asthma is bronchial hyperreactivity [1]. Bronchial reactivity is determined by genetic factors and by exogenous influences. Exogenous influences such as allergens, air pollutants, infection, etc. modify bronchial reactivity by causing airway inflammation. Especially illustrative is the relation between type I allergy and nonspecific bronchial hyperreactivity. The occurrence of a late phase bronchial reaction after allergen inhalation is followed by an increase in nonspecific bronchial hyperreactivity [2]. The activity of the different antiasthmatic drugs on nonspecific bronchial reactivity, airway inflammation and type I allergic reactions will therefore be discussed along with their other pharmacological effects.
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References
Boushey HA, Holtzman MJ, Sheller JR, Nadel JA (1980) Bronchial hyperreactivity. Am Rev Respir Dis 121: 389–413
Cockcroft DW, Ruffin RE, Dolovich J, Hargreave FE (1977) Allergen induced increase in non allergic bronchial reactivity. Clin Allergy 7: 503–513
Richards IM (1983) Pharmacological modulation of bronchial hyperreactivity. Eur J Respir Dis [Suppl] 129: 148–176
Craps LP, Ney UM (1984) Ketotifen: current views on its mechanism of action and their therapeutic implications Respiration 45: 411–421
Hegardt B (1981) Evaluation of the anti-allergic property of the beta-adrenoceptor agonist KWD 2131 in asthmatics. Methodological aspects and clinical trial models. Eur J Respir Dis [Suppl] 115: 1–54
Pauwels R, van der Straeten M (1984) The anti-allergic effect of theophylline. In: Jonkman JHG, Jenne JW, Simons FER (eds) Sustained release theophylline in the treatment of chronic reversible airways obstruction. Excerpta Medica, Amsterdam, pp 9–13
Andersson P, Bergstrand H (1981) Antigen-induced bronchial anaphylaxis in actively sensitized guinea pigs: effect of long-term treatment with sodium cromoglycate and aminophylline. Br J Pharmacol 74: 601–609
Schultze-Werninghaus G (1981) Anticholinergic versus beta-2-adrenergic therapy in allergic airways obstruction. Respiration 41: 239–247
Eiser NM (1982) Histamine antagonists and asthma. Pharmacol Ther 17: 239–250
Schleimer RP, MacGlashan DW, Peters SP, Naclerio R, Proud D, Adkinson NF Jr, Lichtenstein LM (1984) Inflammatory mediators and mechanisms of release from purified human basophils and mast cells. J Allergy Clin Immunol 74: 473–481
Parillo JE, Fauci AS (1979) Mechanisms of glucocorticoid actions on immune processes. Annu Rev Pharmacol Toxicol 19: 179–201
Marom Z, Shelhamer J, Ailing D, Kaliner M (1984) The effects of glucocorticoids on mucous glycoprotein secretion from human airways in vitro. Am Rev Respir Dis 129: 62–65
Burge PS (1982) The effects of corticosteroids on the immediate asthmatic reaction. Eur J Respir Dis (Suppl] 122: 163–166
Ellul-Micallef R, Borthwick RC, McHardy GJR (1974) The time course of response to prednisolone in chronic bronchial asthma. Clin Sci 47: 105–117
Ellul-Micallef R, Fenech FF (1975) Effect of intravenous prednisolone in asthmatics with diminished adrenergic responsiveness. Lancet II: 1269–1270
Sotomayor H, Badier M, Vervloet D, Orehek J (1984) Seasonal increase of carbachol airway responsiveness in patients allergic to grass pollen. Am Rev Respir Dis 130: 56–58
Agnew JE, Bateman JRM, Sheahan NF, Lennard-Jones AM, Pavia D, Clarke SW (1983) Effect of oral corticosteroids on mucus clearance by cough and mucociliary transport in stable asthma. Bull Eur Physiopathol Respir 19: 37–41
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© 1987 Springer-Verlag, Berlin Heidelberg
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Pauwels, R. (1987). Physiopathological Data for the Treatment of Bronchial Asthma. In: Michel, F.B., Bousquet, J., Godard, P. (eds) Highlights in Asthmology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70316-4_50
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DOI: https://doi.org/10.1007/978-3-642-70316-4_50
Publisher Name: Springer, Berlin, Heidelberg
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