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Bronchial Hyperresponsiveness and Asthma: Unanswered Questions

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Highlights in Asthmology
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Abstract

Inhalation of pharmacological agents known to constrict isolated airways results in excessive airway narrowing in patients with asthma as compared to normal subjects (bronchial hyperresponsiveness = BH) [4, 23]. This feature was recognized more than 40 years ago and it has given birth to two commonly accepted concepts.

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References

  1. Bahous J, Cartier A, Quinet G, Pineau L, Malo JL (1984) Non allergic bronchial hyperexcitability in chronic bronchitis. Am Rev Respir Dis 129: 216 – 220

    PubMed  CAS  Google Scholar 

  2. Bahous J, Cartier A, Pineau L, Bernard C, Ghezzo H, Martin RR, Malo JL (1984) Pulmonary function tests and airway responsiveness to methacholine in chronic bronchiectasis of the adult. Bull Eur Physiopathol Respir 20: 375 – 380

    PubMed  CAS  Google Scholar 

  3. Boucher RC, Paré PD, Hogg JC (1979) Relationship between airway hyperreactivity and hyperpermeability in ascaris-sensitive monkeys. J Allergy Clin Immunol 64: 197–201

    Article  PubMed  CAS  Google Scholar 

  4. Boushey HA, Holtzman MJ, Sheller JR, Nadel JA (1980) Bronchial hyperreactivity (State of the Art). Am Rev Respir Dis 121: 389–413

    PubMed  CAS  Google Scholar 

  5. Brown R, Ingram RH, Wellman JJ, McFadden ER (1977) Effects of intravenous histamine on pulmonary mechanics in non-asthmatic and asthmatic subjects. J Appl Physiol 42: 221 – 227

    PubMed  CAS  Google Scholar 

  6. Cartier A, Thomson NC, Frith PA, Roberts R, Tech M, Hargreave FE (1982) Allergen-induced increase in bronchial responsiveness to histamine=relationship to the late asthmatic response and change in airway caliber. J Allergy Clin Immunol 70: 170 – 177

    Article  PubMed  CAS  Google Scholar 

  7. Cockcroft DW, Ruffin RE, Frith PA, Cartier A, Juniper EF, Dolovich J, Hargreave FE (1979) Determinants of allergen-induced asthma: dose of allergen, circulating IgE antibody concentration and bronchial responsiveness to inhaled histamine. Am Rev Respir Dis 120: 1053 – 1058

    PubMed  CAS  Google Scholar 

  8. Easton JG (1981) Effect of an inhaled corticosteroid on methacholine airway reactivity. J Allergy Clin Immunol 67: 388 – 390

    Article  PubMed  CAS  Google Scholar 

  9. Elwood RK, Kennedy S, Belzerg A, Hogg JC, Paré PD (1983) Respiratory mucosal permeability in asthma. Am Rev Respir Dis 128: 523 – 527

    PubMed  CAS  Google Scholar 

  10. Fish JE, Ankin MG, Kelly JF, Peterman VI (1981) Regulation of bronchomotor tone by lung inflation in asthmatic and non-asthmatic subjects. J Appl Physiol 50: 1079 – 1086

    PubMed  CAS  Google Scholar 

  11. Fleury J, Bernaudin JF, Ehouman A, Pinchon MC, Bignon J (1982) Histopathologie des bronches de l’asthmatique. In: Michel FB (ed) Bronches de l’asthmatique. Masson, Paris, pp 14 – 19

    Google Scholar 

  12. Gross NJ, Skorodin MS (1984) Role of the parasympathetic system in airway obstruction due to emphysema. N Engl J Med 311: 421 – 425

    Article  PubMed  CAS  Google Scholar 

  13. Groth S, Lindell SE, Kabiraj MU, Bülow K, Arborelius M, Simonsson BG (1984) Bronchial reactivity and small airway dysfunction in subjects with intermediate alpha,-antitrypsin deficiency. Bull Eur Physiopathol Respir 20: 279 – 284

    PubMed  CAS  Google Scholar 

  14. Haglind P, Bake B, Belin L (1983) Is mild byssinosis associated with small airways disease? Eur J Respir Dis 64: 449 – 459

    PubMed  CAS  Google Scholar 

  15. Hargreave FE, Juniper EF, Ryan G, Dolovich M, Cartier A, Frith PA, Newhouse MT (1980) Clinical significance of non specific airway hyperreactivity. In: Hargreave FE (ed) Airway reactivity. Astra Pharmaceuticals, Mississauga, pp 216 – 221

    Google Scholar 

  16. Holtzman MJ, Fabbri LM, O’Byrne PM, Gold BD, Aizawa H, Walters EH, Alpert SE, Nadel JA (1983) Importance of airway inflammation for hyperresponsiveness induced by ozone. Am Rev Respir Dis 127: 686 – 690

    PubMed  CAS  Google Scholar 

  17. Laitinen LA (1974) Histamine and metacholine challenge in the testing of bronchial reactivity. Scand J Respir Dis [Suppl] 86: 48

    Google Scholar 

  18. Laitinen LA, Haahtela T, Kava T, Laitinen A (1983) Non-specific bronchial reactivity and ultrastructure of the airway epithelium in patients with sarcoidosis and allergic alveolitis. Eur J Respir Dis 64 [Suppl 131]: 267 – 283

    Google Scholar 

  19. Mitchell I, Corey M, Woenne R (1978) Bronchial hyperreactivity in cystic fibrosis and asthma. J Pediatr 93: 744 – 748

    Article  PubMed  CAS  Google Scholar 

  20. Orehek J (1980) Airway response to inhaled bronchoconstrictor drugs: clinical measurement and standardization. In: Hargreave FE (ed) Airway reactivity. Astra Pharmaceuticals, Mississauga, pp 201 – 209

    Google Scholar 

  21. Orehek J (1983) The concept of airway sensitivity and reactivity. Eur J Respir Dis 64 [Suppl 1311: 27 – 48

    Google Scholar 

  22. Orehek J (1983) Pharmacologic airway hyperreactivity. In: Serafini I, Errigo E (eds) Proceedings of the XIIth Congress of the European Academy of Allergology and Clinical Immunology. O.I.C. Medical, Firenze, pp 177 – 182

    Google Scholar 

  23. Orehek J, Gayrard P (1976) Les tests de provocation bronchique non-spécifiques dans l’asthme. Bull Eur Physiopathol Respir 12: 565 – 598

    PubMed  CAS  Google Scholar 

  24. Orehek J, Nicoli MM, Delpierre S, Beaupré A (1981) Influence of the previous deep inspiration on the spirometric measurement of provoked bronchoconstriction in asthma. Am Rev Respir Dis 123: 269 – 272

    PubMed  CAS  Google Scholar 

  25. Permutt S, Rosenthal RR, Norman PS, Menkes HA (1977) Bronchial challenge in ragweed sensitive patients. In: Lichtenstein LM, Austen KF (eds) Asthma. Academic Press, New York, pp 265 – 281

    Google Scholar 

  26. Ramsdell JW, Nachtwey FJ, Moser KM (1982) Bronchial hyperreactivity in chronic obstructive bronchitis. Am Rev Respir Dis 126: 829 – 832

    PubMed  CAS  Google Scholar 

  27. Simpson DL, Goodman M, Spector SL, Petty TL (1978) Long-term follow-up and bronchial reactivity testing in survivors of the adult respiratory distress syndrome. Am Rev Respir Dis 117: 449 – 454

    PubMed  CAS  Google Scholar 

  28. Spector SL, Farr RS (1975) A comparison of methacholine and histamine inhalations in asthmatics. J Allergy Clin Immunol 56: 308 – 316

    Article  PubMed  CAS  Google Scholar 

  29. Sotomayor H, Badier M, Vervloet D, Orehek J (1984) Seasonal increase of carbachol airway responsiveness in patients allergic to grass pollen: reversal by corticosteroids. Am Rev Respir Dis 130: 56 – 58

    PubMed  CAS  Google Scholar 

  30. Stevens WJ, Vermeire PA (1980) Bronchial responsiveness to histamine and allergen in patients with asthma. Eur J Respir Dis 61: 203 – 210

    PubMed  CAS  Google Scholar 

  31. Tiffeneau R (1957) Examen pulmonaire de I’asthmatique. Masson, Paris, p 245

    Google Scholar 

  32. Varpela E, Laitinen LA, Kestinen H, Korhola 0 (1978) Asthma, allergy and bronchial hyperreactivity to histamine in patients with bronchiectasis. Clin Allergy 8: 273 – 280

    CAS  Google Scholar 

  33. Vincenc KS, Black JL, Yan K, Armour CL, Donnelly PM, Woolcock AJ (1983) Comparison of in vivo and in vitro responses to histamine in human airways. Am Rev Respir Dis 128: 875 – 879

    PubMed  CAS  Google Scholar 

  34. Woolcock AJ, Salome CM, Yan K (1984) The shape of the dose-response curve to histamine in asthmatic and normal subjects. Am Rev Respir Dis 130: 71 – 75

    PubMed  CAS  Google Scholar 

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© 1987 Springer-Verlag, Berlin Heidelberg

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Orehek, J. (1987). Bronchial Hyperresponsiveness and Asthma: Unanswered Questions. In: Michel, F.B., Bousquet, J., Godard, P. (eds) Highlights in Asthmology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70316-4_30

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  • DOI: https://doi.org/10.1007/978-3-642-70316-4_30

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70318-8

  • Online ISBN: 978-3-642-70316-4

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