Neutrophils and the Asthmatic Response
The infiltration of neutrophils is an early event following tissue mast cell degranulation. The kinetics of inflammatory cell infiltration following allergic tissue reactions are similar in IgE-mediated reactions in human skin , as well as models of anaphylaxis in the skin and lung of guinea pigs . The initial infiltration of neutrophils is rapid, i.e., within a few hours. This is followed by an accumulation of eosinophils which, in the case of passive cutaneous anaphylaxis in guinea pig skin, was maximal at 8 hours . After this time macrophages become the predominant cell and persist at the site of the IgE-allergen interaction for several days.
KeywordsMast Cell Chemotactic Factor Asthmatic Response Asthmatic Reaction Passive Cutaneous Anaphylaxis
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