Neutrophils and the Asthmatic Response

  • A. B. Kay


The infiltration of neutrophils is an early event following tissue mast cell degranulation. The kinetics of inflammatory cell infiltration following allergic tissue reactions are similar in IgE-mediated reactions in human skin [1], as well as models of anaphylaxis in the skin and lung of guinea pigs [2]. The initial infiltration of neutrophils is rapid, i.e., within a few hours. This is followed by an accumulation of eosinophils which, in the case of passive cutaneous anaphylaxis in guinea pig skin, was maximal at 8 hours [2]. After this time macrophages become the predominant cell and persist at the site of the IgE-allergen interaction for several days.


Mast Cell Chemotactic Factor Asthmatic Response Asthmatic Reaction Passive Cutaneous Anaphylaxis 
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© Springer-Verlag, Berlin Heidelberg 1987

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  • A. B. Kay

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