Mechanisms of IgE-mediated Immediate Reactions

  • A. L. de Weck


The association of immediate allergic reactions with a peculiar category of antibodies denominated reagins became apparent with the experiments of Prausnitz and Küstner [1], passively transferring immediate skin reactions to allergens with serum antibodies, which at the time gave none of the usual serological reactions in vitro, such as precipitation, hemagglutination, etc. Even when the main immunoglobulin classes such as IgG, IgA and IgM were identified at the beginning of the 1960s, the quest for the elusive reagins continued. Only in 1967 could Ishizaka et al [2] and Johannson and Bennich [3] independently attribute the property of causing immediate-type skin reactions to a new class of immunoglobulins, denominated then IgE.


Mast Cell Passive Cutaneous Anaphylaxis Tissue Mast Cell Blood Basophil Mast Cell Trigger 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Prausnitz C, Kästner J (1921) Studien über die Überempfindlichkeit 2. Zentralbl Bakteriol 86: 120Google Scholar
  2. 2.
    Ishizaka K, Ishizaka T, Hornbrook MM (1966) Physicochemical properties of reaginic antibody. V. Correlation of reaginic activity with E globulin antibody. J Immunol 97: 840Google Scholar
  3. 3.
    Johannson SGO, Bennich H (1967) Immunological studies of an atypical (myeloma) immunoglobulin. Immunology 73: 381Google Scholar
  4. 4.
    Farah FS, Kern M, Eisen HN (1960) Specific inhibition of wheal and erythema responses with univalent haptens and univalent antibody fragments. J Exp Med 112: 1211PubMedCrossRefGoogle Scholar
  5. 5.
    Ovary Z, Karush F (1960) Studies on the immunologic mechanisms of anaphylaxis. I. Antibody-hapten interactions studied by passive cutaneous anaphylaxis in the guinea pig. J Immunol 84: 409Google Scholar
  6. 6.
    de Weck AL, Schneider CH (1969) Molecular and stereochemical properties required of antigens for the elicitation of allergic reactions. In: Westphal O, Bock HE, Grundmann E (eds) Current Problems in Immunology. Springer, Berlin Heidelberg New York, p 32Google Scholar
  7. 7.
    Portier P, Richet CH (1902) De l’action anaphylactique de certains venins. CR Soc Biol 54: 170Google Scholar
  8. 8.
    Ovary Z, Taranta A (1963) Passive cutaneous anaphylaxis with antibody fragments. Science 140: 193PubMedCrossRefGoogle Scholar
  9. 9.
    Mota I (1964) The mechanism of anaphylaxis. I. Production and biological properties of mast cell sensitizing antibody. Immunology 1: 681Google Scholar
  10. 10.
    Levine BB, Vaz NM (1970) Effect of combinations of inbred strain, antigen and antigen dose on immune responsiveness and reagin production in the mouse: a potential mouse model for immune aspects of human atopic allergy. Int Arch Allergy 39: 156PubMedCrossRefGoogle Scholar
  11. 11.
    Clausen JT, Spärck JV, Werdelin O, Larsen SO, Lundberg L (1985) Immunogenetic studies of respiratory anaphylaxis in selectively bred guinea pigs. Allergy 40: 15PubMedCrossRefGoogle Scholar
  12. 12.
    Mota I, Perini A, Trinade VS (1974) The mechanism of the adjuvant effect of Bordetella pertussis: the substance responsible for the selective enhancement of IgE antibody production. Int Arch Allergy 47: 425–432PubMedCrossRefGoogle Scholar
  13. 13.
    Vaz NM, Phillips-Quagliata JM, Levine BB, Vaz EM (1971) H-2 linked genetic control of immune responsiveness to ovalbumin and ovomucoid. J Exp Med 134: 1335PubMedCrossRefGoogle Scholar
  14. 14.
    Lundberg L (1979) Guinea pig inbred for studies of respiratory anaphylaxis. Acta Pathol Microbiol Immunol Scand [C] 87: 55Google Scholar
  15. 15.
    Rousseaux-Prévost R, Bazin H, Capron A (1977) IgE in experimental schistosomiasis.I. Serum IgE levels after infection by Schistosoma mansoni in various strains of rats. J Immunol 33: 501Google Scholar
  16. 16.
    McDevitt HO, Chinitz A (1969) Genetic control of the antibody response: relationship between immune response and histocompatibility (H-2) type. Science 163: 1207PubMedCrossRefGoogle Scholar
  17. 17.
    Katz DH (1984) Regulation of the IgE system: experimental and clinical aspects. Allergy 39: 81–106PubMedCrossRefGoogle Scholar
  18. 18.
    Ishizaka K, Ishizaka T (1983) Immunology of IgE-mediated hypersensitivity. In: Middleton E Jr, Reed CE, Ellis EF (eds) Allergy: Principles and Practice, 2nd edn. Mosby, St. Louis, pp 43–73Google Scholar
  19. 19.
    Frick OL (1982) Viral infections as triggers of allergy. In: Steffen C, Ludwig H (eds) Clinical Immunology and Allergology. Elsevier, Amsterdam, pp 283–292Google Scholar
  20. 20.
    Blaser K, de Weck AL (1982) Regulation of the IgE antibody response by idiotype-antiidiotype network. Prog Allergy 32: 203–264CrossRefGoogle Scholar
  21. 21.
    Tada T (1975) Regulation of reaginic antibody formation in animals. Prog Allergy 19: 122PubMedGoogle Scholar
  22. 22.
    Kishimoto T, Hirai Y, Suemura M, Nakanishi K (1978) Regulation of antibody response in different immunoglobulin classes. IV. Properties and functions of IgE class specific suppressor factor(s) released from DNP-mycobacterium primed T cells. J Immunol 121: 2106Google Scholar
  23. 23.
    Chiorazzi N, Vaz DA, Katz DH (1977) Hapten-specific IgE antibody responses in mice. VII. Conversion of IgE “non responder” strains to IgE “responders” by elimination of suppressor T cell activity. J Immunol 118: 48Google Scholar
  24. 24.
    Hirashima M, Yodoi I, Ishizaka K (1981) Regulatory role of IgE-binding factors from rat T lymphocytes. V. Formation of IgE-potentiating factors by T lymphocytes from rats treated with Bordetella pertussis vaccine. J Immunol 126: 838Google Scholar
  25. 25.
    Marsh DG (1975) Allergens and the genetics of allergy. In: Sela M (ed) The Antigens, vol. 3. Academic Press, New York, p 227Google Scholar
  26. 26.
    Neftel KA, Wälti M, Spengler H, de Weck AL (1982) Effect of storage of penicillin G solutions on sensitization to penicillin G after intravenous administration. Lancet I: 986–988Google Scholar
  27. 27.
    Gerrard GW (1979) Allergy in breast-fed babies to ingredients in breast milk. Ann Allergy 42: 169–172Google Scholar
  28. 28.
    Marsh D, Chase G, Friedhoff L (1979) As-sociation of HLA antigens and total serum immunoglobulin E level with allergic response and failure to respond to ragweed allergen Ra3. Proc Natl Acad Sci USA 76: 2903Google Scholar
  29. 29.
    de Weck AL, Blumenthal M, Yunis E, Jean-net M (1977) HLA and Allergy. In: Dausset J, Svjegaard W (eds) HLA and Disease. Williams and Wilkins, BaltimoreGoogle Scholar
  30. 30.
    Fineman SM, Mudawwar FB, Geha RS (1979) Characteristics and mechanisms of action of the concanavalin A-activated suppressor cell in man. Cell Immunol 45: 120PubMedCrossRefGoogle Scholar
  31. 31.
    Geha RS, Reinherz E, Leung D, McKee KT, Schlossman S, Rosen FS (1981) Deficiency of suppressor T cells in the hyperimmunoglobulin E syndrome. J Clin Invest 68: 783Google Scholar
  32. 32.
    Katz DH (1978) Control of IgE antibody production by suppressor substances. J Allergy Clin Immunol 62: 44–55PubMedCrossRefGoogle Scholar
  33. 33.
    Saryan JA, Rappaport J, Leung D, Parkman R, Geha RS (1983) Regulation of human immunoglobulin E synthesis in acute graft versus host disease. J Clin Invest 71: 556Google Scholar
  34. 34.
    Leung D, Brosek C, Frankel R, Geha RS (1983) IgE specific suppressor factors in normal human serum: in vitro and in vivo effects. Clin Res 31: 164AGoogle Scholar
  35. 35.
    Geha RA, Twarog F, Rappaport J, Parkman R, Rosen S (1980) Increased serum IgE levels following allogeneic bone marrow transplantation. J Allergy Clin Immunol 66: 78PubMedCrossRefGoogle Scholar
  36. 36.
    Saryan JA, Leung D, Geha RS (1983) Induction of human IgE synthesis by a factor derived from T cells of patients with hyperIgE states. J Immunol 130: 242–247PubMedGoogle Scholar
  37. 37.
    Capron A, Dessaint JP, Capron M, Bazin H (1975) Specific IgE antibodies in immune adherence of normal macrophages to S. mansoni schistosomules. Nature 253: 474PubMedCrossRefGoogle Scholar
  38. 38.
    Ovary Z (1963) In vitro and in vivo interactions of anti-hapten antibodies with monovalent and bivalent haptens. In: Conceptual Advances in Immunology and Oncology. Hober and Harper, New York, p 206Google Scholar
  39. 39.
    Parker CW, Kern M, Eisen HN (1962) Poly-functional dinitrophenyl haptens as reagents for elicitation of immediate-type allergic responses. J Exp Med 115: 789PubMedCrossRefGoogle Scholar
  40. 40.
    Levine BB, Redmond AP (1968) The nature of the antigen-antibody complexes initiating the specific wheal-and-flare reaction in sensitized man. J Clin Invest 47: 556PubMedCrossRefGoogle Scholar
  41. 41.
    Levine BB (1965) The nature of antigen-antibody complexes which initiate anaphylactic reactions. II. The effect of molecular size on the abilities of homologous multivalent penicilloyl haptens to evoke PCA and passive Arthus reactions in the guinea pig. J Immunol 94: 121PubMedGoogle Scholar
  42. 42.
    de Weck AL, Schneider CH (1972) Specific inhibition of allergic reactions to penicillin in man by a monovalent hapten. I. Experimental studies. Int Arch Allergy 42: 782Google Scholar
  43. 43.
    de Weck AL, Girard JP (1972) Specific inhibition of allergic reactions to penicillin in man by a monovalent hapten. II. Clinical studies. Int Arch Allergy 42: 798Google Scholar
  44. 44.
    de Weck AL, Jeunet F (1975) Clinical trial of Ro 6–0787, a monovalent specific hapten inhibitor of penicillin allergy. Immunobiology 150: 138Google Scholar
  45. 45.
    Ishizaka T, Tomioka H, Ishizaka K (1971) Degranulation of human basophil leukocytes by anti-IgE antibody. J Immunol 106: 705PubMedGoogle Scholar
  46. 46.
    Ishizaka T, Ishizaka K, Bennich H, Johansson SGO (1970) Biologic activities of aggregated immunoglobulin E. J Immunol 104: 854Google Scholar
  47. 47.
    Ishizaka T, Ishizaka K (1978) Triggering of histamine release from rat mast cells by divalent antibodies against IgE receptors. J Immunol 120: 800PubMedGoogle Scholar
  48. 48.
    de Weck AL, Schneider CH, Gutersohn J (1968) The role of penicilloylated protein impurities, penicillin polymers and dimers in penicillin allergy. Int Arch Allergy 33: 535PubMedCrossRefGoogle Scholar
  49. 49.
    Sullivan TJ, Parker KL, Kulczycki A Jr, Parker CW (1976) Modulation of cyclic AMP in purified rat mast cells. III. Studies on the effect of concanavalin A and anti-IgE on cyclic AMP concentration during histamine release. J Immunol 117: 713Google Scholar
  50. 50.
    Jensen C, Nom S, Stahl Skov P, Espersen F, Koch C, Permin H (1984) Bacterial histamine release by immunological and non immunological lectin-mediated reactions. Allergy 39: 371Google Scholar
  51. 51.
    Ishizaka K, Soto S, Ishizaka K (1973) Mechanisms of passive sensitization. III. Number of IgE molecules and their receptor sites on human basophil granulocytes. J Immunol 111: 500Google Scholar
  52. 52.
    Conroy MC, Adkinson NF Jr, Lichtenstein LM (1977) Measurement of IgE on human basophils: Relation to serum IgE and antiIgE induced histamine release. J Immunol 118: 1317Google Scholar
  53. 53.
    May CD, Remigio L (1982) Observations on high spontaneous release of histamine from leukocytes in vitro. Clin Allergy 12: 229PubMedCrossRefGoogle Scholar
  54. 54.
    Conroy MC, de Weck AL (1981) The effect of aspirin and indomethacin on histamine release from leukocytes of patients with suspected intolerance to aspirin. Int Arch Allergy Appl Immunol 66 [Suppl I]: 152Google Scholar
  55. 55.
    Ida S, Hooks JJ, Airaganian RP, Notkins AL (1977) Enhancement of IgE-mediated histamine release from human basophils by viruses: role of interferon. J Exp Med 145: 892PubMedCrossRefGoogle Scholar
  56. 56.
    Foreman J, Jordan C (1983) Histamine release and vascular changes induced by neuropeptides. Agents Actions 13: 105PubMedCrossRefGoogle Scholar
  57. 57.
    Capron A, Dessaint JP, Capron M, Bazin H (1975) Specific IgE antibodies in immune adherence of normal macrophages to Schistosoma mansoni schistosomules. Nature 253: 474–475PubMedCrossRefGoogle Scholar
  58. 58.
    Dessaint JP, Capron A, Joseph M, Bazin H (1979) Cytophilic binding of IgE to the macrophage. II. Immunologic release of lysosomal enzyme from macrophages by IgE and anti-IgE in the rat: A new mechanism of macrophage activation. Cell Immunol 46: 24–36Google Scholar
  59. 59.
    Capron M, Rousseaux J, Mazingue C, Bazin H, Capron A (1978) Rats’ mast cell eosinophil interaction in antibody dependent eosinophil cytotoxicity to Schistosoma man-soni. J Immunol 121: 2518PubMedGoogle Scholar
  60. 60.
    Wenge P (1981) The eosinophil granulocyte and its role in the inflammatory process. In: Wenge A, Lindbom A (eds) The Inflammatory Process. An introduction to the study of cellular and humoral mechanisms. Almqvist and Wiksell, Stockholm, pp 305–327Google Scholar
  61. 61.
    Zheutlin LM, Ackerman SJ, Gleich GH, Thomas LL (1984) Stimulation of basophil and rat mast cell histamine release by eosinophil granule-derived cationic proteins. J Immunol 133: 2180PubMedGoogle Scholar
  62. 62.
    Joseph M, Auriaults C, Capron A, Vorng H, Viens P (1983) A new function for platelets: IgE-dependent killing of schistosomes. Nature 303: 310Google Scholar
  63. 63.
    Ameisen JC, Capron M, Joseph M, Maclouf J, Vorng H, Pancré V, Fournier E, Wallaert B, Tonnel AB (1985) Aspirin-sensitive Asthma: Abnormal platelet response to drugs inducing asthmatic attacks. Int Arch Allergy Appl Immunol 78: 438Google Scholar
  64. 64.
    Knauer KA, Lichtenstein LM, Adkinson NF Jr, Fish JE (1981) Platelet activation during antigen-induced airway reactions in asthmatic subjects. N Engl J Med 304: 1404PubMedCrossRefGoogle Scholar
  65. 65.
    Ishizaka K (1976) Cellular events in the IgE antibody response. Adv Immunol 23: 1PubMedCrossRefGoogle Scholar
  66. 66.
    Frische R, Spiegelberg HL (1978) Fc receptors for IgE on normal rat lymphocytes. J Immunol 121: 471Google Scholar
  67. 67.
    Gell PGH, Coombs RRA (1963) The classification of allergic reactions underlying diseases. In: Gell PGH, Coombs RRA (eds) Clinical Aspects of Immunology. Blackwell, Oxford, p 317Google Scholar

Copyright information

© Springer-Verlag, Berlin Heidelberg 1987

Authors and Affiliations

  • A. L. de Weck

There are no affiliations available

Personalised recommendations