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Mechanisms of IgE-mediated Immediate Reactions

  • A. L. de Weck

Abstract

The association of immediate allergic reactions with a peculiar category of antibodies denominated reagins became apparent with the experiments of Prausnitz and Küstner [1], passively transferring immediate skin reactions to allergens with serum antibodies, which at the time gave none of the usual serological reactions in vitro, such as precipitation, hemagglutination, etc. Even when the main immunoglobulin classes such as IgG, IgA and IgM were identified at the beginning of the 1960s, the quest for the elusive reagins continued. Only in 1967 could Ishizaka et al [2] and Johannson and Bennich [3] independently attribute the property of causing immediate-type skin reactions to a new class of immunoglobulins, denominated then IgE.

Keywords

Mast Cell Passive Cutaneous Anaphylaxis Tissue Mast Cell Blood Basophil Mast Cell Trigger 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag, Berlin Heidelberg 1987

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  • A. L. de Weck

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