Lactic acidosis is defined as a condition characterized by a reduction in plasma bicarbonate concentration secondary to the accumulation of lactate and H ions in the extracellular fluid. However, there is no general consensus concerning the level of lactate and the value of pH required for the diagnosis. The presence of hyperlactatemia does not necessarily correspond to acidosis; it may coexist with a high pH as in respiratory alkalosis. So, lactic acidosis is usually diagnosed in presence of acidemia associated with an increased anion gap mainly due to lactate accumulation.


Blood Lactate Lactic Acidosis Respiratory Alkalosis Alberti KGMM Tissue Anoxia 
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  1. 1.
    Alberti KGMM, Cuthbert C (1982) The hydrogen ion in normal metabolism: a review. In: Metabolic acidosis (CIBA Foundation Symposium 87 ). Pitman Books Ltd, London, pp 1–15CrossRefGoogle Scholar
  2. 2.
    Bossart H, Perret C (1979) Lactate in acute conditions. Proceedings of an International Symposium on Lactate in Acute Conditions, Basel 1978, 1 volume of 148 pages. Karger, BaselGoogle Scholar
  3. 3.
    Carr DB, Shih VE, Richter JM, Martin JB (1981) D-lactic acidosis simulating a hypothalamic syndrome after bowel bypass. Ann Neurol 11: 195–197CrossRefGoogle Scholar
  4. 4.
    Cohen RD, Woods HF (1983) Lactic acidosis revisited. Diabetes 32: 181–191PubMedGoogle Scholar
  5. 5.
    Feihl F, Domenighetti G, Perret C (1982) Intoxication massive au cyanure avec évolution favorable. Etude hémodynamique. Schweiz Med Wschr 112: 1280–1282PubMedGoogle Scholar
  6. 6.
    Huckabee WE (1961) Abnormal resting blood lactate. Significance of hyperlactatemia in hospitalized patients. Am J Med 30: 833–839CrossRefGoogle Scholar
  7. 7.
    Kreisberg RA (1980) Lactate homeostasis and lactic acidosis. Ann Intern Med 92: 227–237PubMedGoogle Scholar
  8. 8.
    Oh MS, Traube M, Barbosa-Saldivar JL, Boxhill C, Carroll HJ (1979) D-Lactic acidosis in a man with short-bowel syndrome. N Engl J Med 301: 249–252PubMedCrossRefGoogle Scholar
  9. 9.
    Perret C, Poli S, Enrico JF (1969/70) Lactic acidosis and liver damage. Helv Med Acta 35: 377–405Google Scholar
  10. 10.
    Perret C, Enrico JF (1979) Lactate in acute circulatory failure. In: Bossart H, Perret C (eds) Lactate in acute conditions. International Symposium, Basel 1978. Karger, Basel, pp 69–82Google Scholar
  11. 11.
    Poli S, de Kalbermatten JP, Enrico JF, Perret C (1971) Crise épileptique et perturbations acidobasiques. Helv Med Acta Suppl 50: 120Google Scholar
  12. 12.
    Relman AS (1978) Lactic acidosis. In: Acid-base and potassium homeostasis. Churchill-Livingstone, New York, pp 65–100Google Scholar
  13. 13.
    Vincent JL, Dufaye PH, Berre J, Leeman M, Degaute JP, Kahn RJ (1983) Serial lactate determinations during circulatory shock. Crit Care Med 11: 449–451PubMedCrossRefGoogle Scholar
  14. 14.
    Wise PH, Chapman M, Thomas DW, Clarkson AR, Harding PE, Edwards JE (1976) Phenformin and lactic acidosis. Br Med J 1: 70–72PubMedCrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1985

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  • Cl. Perret

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