Involvement of Oxygen Radical in Pulmonary Edema

  • A. E. Taylor
  • D. Martin
Part of the Anaesthesiologie und Intensivmedizin / Anaesthesiology and Intensive Care Medicine book series (A+I, volume 178)


The movement of fluid (Jv) across the pulmonary microvascular barrier is determined by the balance between hydrostatic forces (difference between capillary pressure (Pc) and interstitial fluid pressure (Pt)) and the colloid osmotic gradient which is present across the capillary wall (colloid osmotic pressure of the plasma proteins (πp) minus the colloid osmotic pressure of tissue fluid (πt)). The equation which describes the phenomena of transvascular fluid flux is [19, 37]:
$${J_v} = {K_{FC}}\left[ {\left( {{P_c} - {P_t}} \right) - \sigma \left( {{\pi _p} - \pi {}_t} \right)} \right],$$
where KF,C and σ are the filtration coefficient and reflection coefficient of the plasma proteins, respectively. These two parameters are related to the volume conductance of the capillary wall (KF,C) and the capillary wall selectivity to plasma proteins (σ). πp - πt in the osmotic gradient acting across the capillary wall, but it is a function of how leaky the capillary wall is to the plasma proteins, since the more leaky capillaries will have higher πt’s. For the remainder of this paper, we will refer to either hydrostatic or permeability mediated edema when referring to movement of fluid between plasma and lung interstitium. But, many physiological and pathological situations may also alter the integrity of the alveolar-epithelial membrane and could theoretically cause edema without altering the permeability characteristics of the capillary wall.


Pulmonary Edema Capillary Pressure Capillary Wall Phorbol Myristate Acetate Interstitial Fluid Pressure 
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© Springer-Verlag Berlin Heidelberg 1985

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  • A. E. Taylor
  • D. Martin

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