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The Tetracyclines pp 317–392Cite as

Mode of Action of the Tetracyclines and the Nature of Bacterial Resistance to Them

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 78))

Abstract

In an introductory chapter to a symposium on biochemical studies of antimicrobial drugs, Gale (1966) suggests that advances in the development or use of a particular antibiotic will depend upon answers to at least five questions:

  1. 1.

    What is the precise mechanism of the (selectively) toxic action?

  2. 2.

    What is the site of the toxic action within the sensitive cell?

  3. 3.

    Why is the action selective?

  4. 4.

    What is the relationship between the chemical structure of the drug and the chemistry of the sensitive site?

  5. 5.

    By what mechanisms do normally sensitive (microbial) cells become resistant to the toxic action?

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  1. I. Chopra
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  1. Medical Research Division, Lederle Laboratories, American Cyanamid Company, 10987, Pearl River, NY, USA

    J. J. Hlavka

  2. 418 E. Longport, P.O. Box 1004, 08740, Ocean Gate, NJ, USA

    J. H. Boothe

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Chopra, I. (1985). Mode of Action of the Tetracyclines and the Nature of Bacterial Resistance to Them. In: Hlavka, J.J., Boothe, J.H. (eds) The Tetracyclines. Handbook of Experimental Pharmacology, vol 78. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70304-1_6

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