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Interaction of Frog Virus 3 with the Cytoskeleton

  • Chapter
Iridoviridae

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 116))

Abstract

The eukaryotic cell contains a detergent-insoluble structural framework termed the cytoskeleton (Brown etal. 1976; Lenk etal. 1977; Osborn and Weber 1977; Webster et al. 1978). The principal components of the cytoskeleton are three chemically and morphologically distinct filaments: the microtubules, the intermediate filaments, and the microfilaments. The three filaments have been well characterized both morphologically and biochemically. Microtubules are hollow tubes measuring 22–26 nm in diameter and each microtubule contains protofilaments which in turn are composed of heterodimers of tubulin (Olmsted and Borisy 1973). Intermediate filaments are wavy filaments measuring 7–11 nm in diameter (Lazarides 1981). At present, four classes of intermediate filaments have been identified (Lazaredes 1981). They are keratin filaments of epithelial cells, neurofilaments of neurons, glial filaments of cells of glial origin (e.g., astrocytes), and a class of intermediate filaments common to all cell types. Though morphologically similar, each class of intermediate filaments contains distinct proteins. Microfilaments measure 4–8 nm in diameter (Goldman et al. 1975) and contain subunits of actin (Groeschel-Stewart 1980).

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Author notes

  1. M. Chen

    Present address: Department of Biochemistry, University of Beijing, Beijing, China

Authors and Affiliations

  1. Department of Virology and Molecular Biology, St. Jude Children’s Research Hospital, Memphis, TN, 38101, USA

    K. G. Murti, R. Goorha & M. Chen

Authors
  1. K. G. Murti
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  2. R. Goorha
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  3. M. Chen
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Editors and Affiliations

  1. Laboratories of Virology and Molecular Biology, St. Jude Children’s Research Hospital, P.O Box 318, TN 98101, Memphis, USA

    Dawn B. Willis

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© 1985 Springer-Verlag Berlin Heidelberg

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Murti, K.G., Goorha, R., Chen, M. (1985). Interaction of Frog Virus 3 with the Cytoskeleton. In: Willis, D.B. (eds) Iridoviridae. Current Topics in Microbiology and Immunology, vol 116. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70280-8_6

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  • DOI: https://doi.org/10.1007/978-3-642-70280-8_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70282-2

  • Online ISBN: 978-3-642-70280-8

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