Abstract
The best studied member of the Iridoviridae is frog virus 3 (FV3), isolated by Granoff et al. (1966) from a renal adenocarcinoma of the leopard frog, Rana pipiens. Similar isolates were made from normal frog kidney and liver (FV1, FY 2, FV5–FY24), but FV3 was chosen for further investigation because of its presence in the tumor. As it turned out, this unusual cytoplasmic DNA virus bore no causal or even helper relationship to the tumor, which was the result of infection with the Lucké herpesvirus (Naegele et al. 1974), but it did have a number of interesting characteristics that made it a worthy object of study in its own right. FV3 is probably similar or identical to other amphibian virus isolates obtained from bullfrogs, newts, and toads (Wolf et al. 1968; Clark et al. 1969).
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Willis, D.B., Goorha, R., Chinchar, V.G. (1985). Macromolecular Synthesis in Cells Infected by Frog Virus 3. In: Willis, D.B. (eds) Iridoviridae. Current Topics in Microbiology and Immunology, vol 116. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70280-8_5
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