Abstract
Isosorbide-5-mononitrate (IS-5-MN) like other nitrates, leads to a reduction of left ventricular (LV) filling pressure and to a moderate arteriolar dilatation. This results in a reduction of myocardial oxygen consumption. The changed hemodynamic conditions can also be demonstrated by noninvasive techniques using one- and two-dimensional echocardiography. A clear improvement in the parameters of contractility could be demonstrated in a group of 25 patients with severe hemodynamically effective coronary heart disease after 20 mg IS-5-MN orally by means of parameters of LV function. The administration of 40 mg produced only slight additional, but statistically nonsignificant, changes.
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© 1985 Springer-Verlag Berlin Heidelberg
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Bergbauer, M., Sabin, G. (1985). The Effects of Isosorbide-5-Mononitrate on Left Ventricular Function Assessed by Systolic Time Intervals. In: Cohn, J.N., Rittinghausen, R. (eds) Mononitrates. International Boehringer Mannheim Symposia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70234-1_34
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DOI: https://doi.org/10.1007/978-3-642-70234-1_34
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-15107-4
Online ISBN: 978-3-642-70234-1
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